#283 - Brain health explained: Insulin resistance, biomarkers, and Alzheimer’s risk | Dr. David Perlmutter & Mike Haney

#283 - Brain health explained: Insulin resistance, biomarkers, and Alzheimer’s risk | Dr. David Perlmutter & Mike Haney

Alzheimer’s and dementia aren’t just a matter of age or genetics. Increasing evidence shows that metabolic health—particularly insulin resistance—plays a key role in cognitive decline.


In this episode of A Whole New Level, neurologist and bestselling author Dr. David Perlmutter joins Mike Haney to explore the links between brain health and metabolism. They discuss the role of insulin resistance and inflammation in Alzheimer’s disease, the biomarkers that can reveal risk decades before symptoms, and how lifestyle interventions can dramatically change your trajectory.


Topics include:

  • Key biomarkers for assessing brain health: fasting insulin, A1C, homocysteine
  • Why targeting inflammation may matter more than targeting amyloid plaques
  • The promise and limitations of GLP-1 medications for dementia and Parkinson’s
  • Practical steps you can take now to protect long-term cognitive function


Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl


🎙 What Dr. David Perlmutter & Mike Haney discuss:

4:12 — Why Alzheimer’s is now called “Type 3 diabetes”

9:45 — The role of inflammation in brain health

15:22 — Biomarkers that predict dementia risk decades early

22:31 — Why mainstream Alzheimer’s drugs fall short

29:17 — GLP-1s and brain health

36:44 — Lifestyle changes vs. pharmaceuticals

44:19 — Why homocysteine matters

53:02 — Sleep, circadian rhythm, and brain resilience

1:02:38 — Early warning signs you shouldn’t ignore

1:15:07 — The hopeful message


Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.


Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.


🔗 Helpful links:
Watch the conversation: https://youtu.be/MV_9nyAN1Vk

Find us on YouTube: https://youtube.com/levelshealth?sub_confirmation=1


📲 Connect:

Dr. David Perlmutter on X: @DavidPerlmutter

David Perlmutter, MD: ⁠https://drperlmutter.com/⁠

Avsnitt(285)

#5 – No turning back (Josh Clemente & Ben Grynol)

#5 – No turning back (Josh Clemente & Ben Grynol)

In the summer of 2019, things started moving forward for Josh & Sam, as the two of them got traction with Levels. The company was no longer called Frontier Biometric, and both investors and friends alike were keeping an eye on what they were working on. It didn't take long before things started moving with velocity. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (05:04) - The Levels team finds another founder (10:02) - The surreal feeling of gaining momentum (13:50) - Organizing the greatest minds they knew (16:14) - Digging into the data (17:31) - A weekend full of potential (19:42) - Putting the cart before the horse (22:26) - The pieces fall into place (25:43) - Selling an idea (26:29) - Now we had deliverables (29:51) - A medical professional to challenge the status quo (30:26) - The fifth founder: Dr. Casey Means Transcripts & Show Notes

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#4 – The juice cart (Josh Clemente & Ben Grynol)

#4 – The juice cart (Josh Clemente & Ben Grynol)

In April of 2019, Josh turned 30 and was about to move on from Frontier Biometric. At that point, he had been working on the project for more than a year and had exhausted all channels to get traction. Shortly after his birthday, he got a call from Sam Corcos and they started catching up – the conversation ended up being a catalyst in moving the company forward. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (06:07) - Honing the Levels pitch (10:00) - The importance of asking all the right questions (12:47) - Diving into the research (19:42) - The juice cart story (20:38) - Josh’s unexpected blood sugar spike (21:44) - A real-life example of CGM in action (23:00) - Investing in Sam Corcos (25:43) - Forward work (26:21) - Creating a partnership (31:57) - The benefit of complementary areas of expertise (35:23) - How Levels got its name Transcripts & Show Notes

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#3 – The road trip that changed it all (Josh Clemente & Ben Grynol)

#3 – The road trip that changed it all (Josh Clemente & Ben Grynol)

By mid-2018, Josh was all in on Maple Biometrics. But, he started to feel disenfranchised by the rejection he faced in bringing Continuous Glucose Monitoring to the mass market. It wasn't until there was a serendipitous encounter on a road trip from Los Angeles to Philadelphia that ended up changing the course of the company. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (03:04) - How do you sell to someone who doesn’t know they have a problem? (03:52) - The need for a clear value-add and maximized distribution (05:58) - The decision to focus on non-invasive hardware (09:50) - The road trip that crossed paths with Sam Corcos (13:06) - Trying to partner with a physician organization (14:38) - An eventful 30th birthday Transcripts & Show Notes

26 Apr 202115min

#2 – From selling cars, to building rockets (Josh Clemente & Ben Grynol)

#2 – From selling cars, to building rockets (Josh Clemente & Ben Grynol)

After graduating from college, Josh Clemente, Founder of Levels, found himself selling used cars while he held out for his dream job – an opportunity to work at Tesla. Although Tesla didn't work out, someone suggested that Josh apply to SpaceX and this changed the course of his career. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (06:12) - How Josh’s father provided a career role model (09:05) -  Catching attention with a killer capstone project (21:16) - The journey to SpaceX (25:13) - What happens when you take work to the limit (27:04) - Leaving SpaceX to explore new ideas (34:14) - The scientific paper that inspired Josh’s obsession with metabolism (40:34) - Feeling frustration when denied access to a CGM (44:15) - How a CGM provided a lightbulb moment (47:53) - Building out the original business plan Transcripts & Show Notes

13 Apr 202149min

#1 – A Whole New Level: Intro

#1 – A Whole New Level: Intro

Welcome to Levels. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (00:33) - An MVP approach to making a podcast (01:45) - A rotating cast of characters and experts (02:32) - Topics A Whole New Level will cover Transcripts & Show Notes Become a Levels Member – https://levels.link/wnl⁠ Learn about Metabolic Health – levelshealth.com/blog Follow Levels on Social – @Levels on Instagram and Twitter

13 Apr 20213min

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