Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1414)

Dr. John Salerno: Holistic Medicine, Heavy Metals & Allergies - #211

Dr. John Salerno: Holistic Medicine, Heavy Metals & Allergies - #211

Why you should listen –  Dr. John Salerno comes on Bulletproof Radio today to discuss holistic versus Western medicine, heavy metal exposure, ultra violet light and its benefits, and hacking your allergies. Enjoy the show! Dr. John Salerno is the founder of The Salerno Center for Complementary Medicine in New York, and the chief medical officer at Renulife, an anti-aging and dermatological clinic in Sao Paolo, Brazil. He has authored 3 books, The Silver Cloud Diet, The Salerno Solution, and Fight Fat with Fat. He has his own line of advanced vitamins and is best known for his work on organic nutrition, hormone replacement, and chelation therapy. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Apr 201552min

   Jonathan Bailor: SANE Solutions, Counting Calories & Online Trolls - #210  

   Jonathan Bailor: SANE Solutions, Counting Calories & Online Trolls - #210  

Why you should listen –     Jonathan Bailor comes on Bulletproof Radio to discuss SANE Solutions a new way to understand your food, why quality over quantity is important, and why calorie counting doesn’t work. Enjoy the show!     Jonathan Bailor is a New York Times bestselling author and internationally recognized wellness expert who specializes in using modern science and technology to simplify health. Bailor has collaborated with top scientists for more than 10 years to analyze and apply over 1,300 studies. His work has been endorsed by top doctors and scientists from Harvard Medical School, Johns’ Hopkins, The Mayo Clinic, The Cleveland Clinic, and UCLA.    Bailor is the founder of SANESolution.com and serves as the CEO for the wellness technology company Yopti®. He authored the New York Times and USA Today bestselling book The Calorie Myth, hosts a popular syndicated health radio show The SANE Show and blogs on The Huffington Post. Additionally, Bailor has registered over 25 patents, spoken at Fortune 100 companies and TED conferences for over a decade, and served as a Senior Program Manager at Microsoft where he helped create Nike+ Kinect Training and XBox Fitness.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Apr 201555min

David Waknine: Adversity, Filming A Documentary & Weight Loss - #209

David Waknine: Adversity, Filming A Documentary & Weight Loss - #209

Why you should listen – David Waknine comes on Bulletproof Radio today to discuss what its like to get back in the ring, fighting through adversity, filming his new documentary, training and injuries. Enjoy the show! David Waknine is the founder of Hollywood Fight Club Productions and Pinocchio’s Playhouse. He is a former boxer and one of the finalists in the Golden Gloves Boxing tournament. He has written and directed over 150 plays, commercials, and short films. He is currently the director and star of his upcoming documentary, One More Round, a documentary about a journey of a former Golden Gloves finalist returning to the ring and challenges he faces like injury, and weight loss. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Apr 201536min

Daniel Pardi: Date Rape Drugs, Napping, & Jet Lag - #208

Daniel Pardi: Date Rape Drugs, Napping, & Jet Lag - #208

Why you should listen – Daniel Pardi comes on Bulletproof Radio today to discuss jet lag, sleep disorders like insomnia and narcolepsy, date rape drugs and the science of napping. Enjoy the show! Daniel Pardi is a researcher in Psychiatry and Behavioral Sciences. He developed the Loop Model to Sustain Health Behaviors and created humanOS.me and dansplan.com to educate people on how to facilitate optimal health behaviors. He has consulted with the Naval Special Warfare department on how to make fighters more vigilant in combat and non-combat conditions, and has given keynote addresses at events like Paleo f(x). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Apr 20151h 3min

Bulletproof Radio Q&A - #207

Bulletproof Radio Q&A - #207

Why you should listen – On this episode of Bulletproof Radio, we have carefully selected the best questions from Facebook, Twitter, and the Bulletproof® Forums for another awesome Q&A. Hear Dave answer questions with Zak about Diet Coke, moldy homes, nootropics and a lot of other great questions that our listeners have submitted to Bulletproof Radio. This episode has a ton of great information all condensed into one, enjoy! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Mars 201542min

Dr. Tami Mergalia: Testosterone Supplementation, Skinny Fat, & Adrenal Fatigue - #206

Dr. Tami Mergalia: Testosterone Supplementation, Skinny Fat, & Adrenal Fatigue - #206

Dr. Tami Mergalia is a double board certified physician in Aesthetic Medicine, Integrative & Natural Medicine, and the owner of Vitality Medical Clinic in Seattle. She is a faculty member of the American Academy of Aesthetic Medicine and a national trainer in Medicis. She has travelled the world as a trainer in advanced injection techniques and lecturing on aesthetics and bioidentical hormones for men and women. She has been featured in Shape Magazine, Fox News and her new book, The Hormone Secret, lays out the secret weapons for anti aging, weight loss, and increased vitality.   Why you should listen – Dr. Tami Mergalia comes on Bulletproof Radio to discuss adrenal fatigue, the importance of your circadian rhythm, what it means to be skinny fat, and the pros and cons of testosterone supplementation. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Mars 201546min

Wendy Myers: Heavy Metal Toxicity, Mineral Power, & Coffee Enemas – #205

Wendy Myers: Heavy Metal Toxicity, Mineral Power, & Coffee Enemas – #205

Wendy Myers is the Founder and Chief Eating Officer of the Liveto110 Blog and host of the Liveto110 podcast show. She is a certified holistic health and nutrition coach, a functional diagnostic nutritionist, and creator of Mineral Power program that utilizes hair mineral analysis to help clients fix mineral deficiencies for a broad spectrum of health conditions. She specializes in using alternative detoxification treatments and diet to help people live healthier lifestyles and is currently working on her next book, The Modern Paleo Survival Guide. Why you should listen – Wendy comes on Bulletproof Radio to discuss how to detox heavy metals, hair mineral test analysis, coffee enemas, and living to 110. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Mars 201544min

Rocco Dispirito: Cook Your Butt Off - #204

Rocco Dispirito: Cook Your Butt Off - #204

Rocco Dispirito is a James Beard award-winning chef and author of eleven books, including the New York Times Best-selling Now Eat This!, The Pound a Day Diet, and his newest book, Cook Your Butt Off. He was named Food & Wine’s Best New Chef, was the first chef to grace the cover of Gourmet as “America’s Most Exciting Young Chef”, and opened the 3-star Union Pacific Restaurant in New York City. Why you should listen –   Rocco comes on Bulletproof Radio to discuss modern cooking, food cravings, activity tracking in the kitchen, and why food should do more than just taste good. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Mars 201558min

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