Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1414)

Marc Goodman: Cyber Security, Transhumanism, & Future Crimes  - #203

Marc Goodman: Cyber Security, Transhumanism, & Future Crimes - #203

Why you should listen – Marc comes on Bulletproof Radio to discuss transhumanism, the dangers of technology, cyber security precautions you can take to protect yourself from cyber threats and cyber crime, and the story behind The Silk Road. Enjoy the show! Marc Goodman is the founder of the Future Crimes Institute and currently serves as the Chair for Policy, Law and Ethics at the Silicon Valley’s Singularity University. Over the past 20 years, Marc has worked with Interpol, the United Nations’ Counterterrorism Task Force, NATO, and the US Government as a global strategist and consultant about the impact of technology on security, business, and international affairs. He has also worked as a police officer and undercover investigator, and has been published in business and technology publications such as The Economist, the Harvard Business Review, and Forbes, and been featured on a myriad of news networks, including CNN, ABC, NBC, BBC, and Fox News. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Mars 201557min

Tom Malterre: Gluten, the Gut Microbiome, & the Elimination Diet  - #202

Tom Malterre: Gluten, the Gut Microbiome, & the Elimination Diet - #202

Tom Malterre is an advanced Functional Medicine-trained Nutritionist with over 10 years of clinical experience working with nutrient deficiencies, chemical exposures, and the gut microbiome. He has degrees from Bastyr University and the Institute of Functional Medicine, is a faculty member of the Autism Research Institute, a medical affairs member of Thorne Research, and even done an entire TEDx Talk on the benefits of broccoli. Tom has co-authored two gluten-free cookbooks, including his newest book, The Elimination Diet, and has been teaching and practicing gluten-free principles since long before gluten-free was even trendy. Why you should listen –   Tom comes on Bulletproof Radio to discuss why gluten and dairy are addictive like opium, the minimum length of time for elimination diets to be effective, the gut microbiome, and the benefits of raw vs cooked vegetables. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Mars 20151h 2min

Jen Wittman: Thyroid, PTSD, & Medicinal Cannabis  - #201

Jen Wittman: Thyroid, PTSD, & Medicinal Cannabis - #201

Jen Wittman is a Certified Holistic Health Expert & Coach specializing in practical solutions for those suffering from thyroid and autoimmune conditions. She provides one-of-a-kind, long-lasting health overhauls at her sites, Thyroid Loving Care, The Healthy Plate, and Your Best Thyroid Life. She is author of the book: Healing Hashimoto's Naturally and the popular guides: The Super-Mom's Guide to Managing Thyroid Disease and The Partner's Guide to Thyroid & Autoimmune.   Why you should listen –     Jen comes on Bulletproof Radio to discuss the relationship between PTSD and food, how to manage Hashimoto’s Thyroiditis, the misdiagnosis of autoimmune diseases, and the therapeutic use of CBD oil and cannabis. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Mars 201551min

Rick Doblin: Psychedelic Healing with Marijuana, MDMA, Psilocybin, & Ayahuasca  - #200

Rick Doblin: Psychedelic Healing with Marijuana, MDMA, Psilocybin, & Ayahuasca - #200

Rick Doblin is the Founder and Executive Director of the Multidisciplinary Association for Psychedelic Studies (MAPS), a non-profit research and educational group that he started in 1986 to develop medical, legal, and cultural contexts for people to benefit from the careful use of psychedelics and marijuana. Rick has a Ph.D. in Public Policy from the Harvard Kennedy School of Government, and also studied under Dr. Stanislav Grof, becoming one of the first practitioners to be certified in Holotropic Breathing. Rick works to progress the research and education behind the benefits of psychedelics and marijuana primarily as prescription medicines, but also for personal growth for otherwise healthy people. Why you should listen – Rick comes on Bulletproof Radio for an extended episode to discuss the safe use of psychedelics as medicine, floatation tanks and Holotropic Breathing as psychedelic alternatives, the dark side of recreational psychedelic substances, and the therapeutic use of substances such as psilocybin, MDMA, ayahuasca, and cannabis. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Mars 20151h 44min

Dr. Tim Jackson: Heavy Metal Toxicity, MTHFR, & Genetic Testing - #199

Dr. Tim Jackson: Heavy Metal Toxicity, MTHFR, & Genetic Testing - #199

Dr. Tim Jackson is a Functional Endocrinologist, a Doctor of Physical Therapy (DPT), and an expert in nutritional biochemistry and digestive health. He is the featured doctor for the MTHFR Support group of healthcare professionals, and the founder of HealYourBody.org, and works to educate the healthcare community and public about the role of methylation in both health and disease. He is also trained in Active Release Technique, and is working on his certification as a Certified Nutrition Specialist (CNS).   Why you should listen –     Dr. Tim comes on Bulletproof Radio to discuss heavy metal detoxification, the MTHFR gene, methylation and genetic testing, and why it is so important to prevent disease instead of needing to fix it. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Feb 201556min

James Baber: Toxic Mold: The Hidden Dangers - #198

James Baber: Toxic Mold: The Hidden Dangers - #198

James Baber is a Senior Product Management professional with more than eighteen years of experience in technology product management, development, and operations. James is on Bulletproof Radio not because of his experience and knowledge in technology and business, but because he is a survivor of toxic mold exposure and has a wealth of information to share about this little-known problem that could be affecting over 100 million people in the US. James will be featured in the upcoming documentary, Moldy, which chronicles the dangers of environmental toxic mold, and sheds light on just how big of a problem it is, and how to go about dealing with it.   Why you should listen –     James comes on Bulletproof Radio to discuss his story of toxic mold exposure, the long list of symptoms you experience when exposed to mold, the reasons why doctors don’t consider mold exposure to be a serious problem, and the important lab tests and data that help with diagnosing mold exposure. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Feb 201557min

Abel James: Fat, Food Labeling, & His Wild Diet - #197

Abel James: Fat, Food Labeling, & His Wild Diet - #197

My friend Abel James, the Fat Burning Man, has been off the grid working on his new book, The Wild Diet. Abel has been on Bulletproof Radio before, and we have done a number of video series and interviews together. It's always great to get him back on the show!   Why you should listen –     Abel comes on Bulletproof Radio to discuss why food is more than just fuel, the ideal body fat percentage, why it’s so important to reconnect with nature, and some dirty little secrets about food labeling – is the food industry really putting beaver butts in our food?! Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Feb 201556min

Stew Friedman: Success, Leadership, & Less Work - #196

Stew Friedman: Success, Leadership, & Less Work - #196

Stew Friedman is a Practice Professor of Management at UPenn’s Wharton Business School, and the Founding Director of the Wharton Work/Life Integration Project. Stew is also the author of the award-winning best-seller, Total Leadership, which utilizes the exercises taught in his classroom at Wharton to increase leadership capacity and performance in all areas of life, not just business. His newest book, Leading the Life You Want, builds on the skills taught in Total Leadership to help people develop a better work-life balance and find more meaning and satisfaction with their jobs and relationships. In addition, Stew is a regular contributor to publications such as the Harvard Business Review, and has served in an advisory role for a wide range of companies and organizations, including the US Department of Labor, the United Nations, and even two White House administrations.   Why you should listen –     Stew comes on Bulletproof Radio to discuss how to find your mission and purpose in life, the science of leadership, mastermind groups, and why you can get more done by focusing less on work. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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