Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1414)

Dominic D’Agostino: Ketosis & Oxygen Toxicity – #187

Dominic D’Agostino: Ketosis & Oxygen Toxicity – #187

Dominic D’Agostino is a neuroscientist, a researcher in the fields of molecular pharmacology and physiology, and assistant professor at the University of South Florida. His research on the impact of ketogenic diets on cell metabolism, and their neuroprotective effects on oxygen toxicity, is supported by the Office of Naval Research, US Department of Defense, and the Alzheimer’s Association. Dom is a member of the Aerospace Medical Association, the Undersea and Hyperbaric Medicine Society, the Society of Neuroscience, the American Physiological Society, and also serves on the Editorial Board for the Journal of Applied Physiology, and as a reviewer for several other scholarly publications. He is one of the world’s foremost experts on ketosis and ketogenic supplements such as MCT oil.   Why you should listen –     Robert comes on Bulletproof Radio, live from the Bulletproof Conference, to discuss his metabolic therapy research, how starvation can be beneficial for brain metabolism, how ketones and ketogenic diets can enhance performance, and the use of MCT oil and ketogenic supplements. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Jan 201537min

Bill Harris: Hacking Meditation with Holosync - #186

Bill Harris: Hacking Meditation with Holosync - #186

Bill Harris is the Founder, President, and Director of the Centerpointe Research Institute and creator of the Holosync Solution program, which utilizes sound technology to alter brain-wave patterns to enhance meditation and create mental, emotional, spiritual, and health benefits. Bill is a Certified Trainer of Neuro Linguistic Programming, is trained in Ericksonian Hypnosis, and has degrees from Berklee College of Music, Portland State University, and the University of Portland. He specializes in using contemporary psychology, Eastern philosophy, chaos theory, and neurotechnology to affect human evolution, change, and healing. Bill has shared the stage with many of the world’s top human potential leaders, including the Dalai Lama, Dr. Stephen Covey, Jack Canfield, and Sir Richard Branson, and nearly 2 million people in over 190 countries have used Centerpointe programs to improve their lives. Why you should listen – Bill comes on Bulletproof Radio to discuss sound-influence on the brain, the benefits of meditation and Holosync Sound Technology, how to control awareness and your reactions to trauma, and maximizing your performance impact. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Jan 20151h 8min

Robert Lee: Breathing for Performance, Focus, & Freediving – #185

Robert Lee: Breathing for Performance, Focus, & Freediving – #185

Robert Lee is a resident fellow in Law, Science, & Technology at Stanford University, an innovation advisor at Singularity University, and an instructor with Performance Freediving. He has a JD/MBA from UC Berkeley, and a BS in Biochemistry & BA in philosophy from Yale University, and has served in a number of roles throughout Silicon Valley, including as CEO of Fly Online, and VP of Intellevate. He has authored a paper published in the Journal of Applied Physiology, is certified as a personal trainer with the American College of Sports Medicine, is a member of both the CA State Bar and US Patent Bar, and has been a guest speaker at entities such as Google, Twitter, UC Berkeley and Stanford business and law schools, as well as the 2014 Bulletproof Biohacking Conference. Why you should listen – Robert comes on Bulletproof Radio, live from the Bulletproof Conference, to discuss the art of respiratory hacking, how to train to breathe differently, the relationship between breathing and emotion and cognitive functioning, and how to mindfulness breathing to everyday life. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Jan 201529min

Bulletproof Radio 2014 in Review! – #184

Bulletproof Radio 2014 in Review! – #184

Thanks for making 2014 a huge year for Bulletproof Radio! There are so many things to be grateful for – hitting #1 overall in the Health category on iTunes, surpassing 10 million downloads, and having incredible guests on the show to share life-changing biohacks and information. I appreciate you for tuning in and subscribing to our audio and video channels - making 2014 our most successful year ever!!! There are so many exciting things to look forward to in 2015, unbelievable guests, top of the line upgrades, and the best in Biohacking. This episode is a recap of the interviews from 2014, and features short clips of the best biohacks, bits of motivation, and pieces of life-upgrading information from every episode. Thanks for making 2014 a huge year for Bulletproof Radio, and enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Dec 20141h 27min

Alan Cash: Upgraded Aging & Living Longer with Oxaloacetate – #183

Alan Cash: Upgraded Aging & Living Longer with Oxaloacetate – #183

Alan Cash is the CEO of Terra Biological LLC, and clinical trials supervisor and medical researcher responsible for the creation of Bulletproof Upgraded Aging Formula. His efforts and persistence in pursuing the research and development of nutritional supplements around the caloric-restriction mimetic compound oxaloacetate have resulted in some profound breakthroughs regarding potential solutions for cognitive decline and anti-aging. Why you should listen: Alan comes on Bulletproof Radio to discuss the latest research on optimal cognitive functioning, steps you can take to produce more mitochondrial mass, the benefits of oxaloacetate supplementation, and what you can do to lessen brain damaging inflammation. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Dec 201425min

Dr. Dwight Jennings: A Live Look at Bite Realignment & How TMJ Impedes Performance #182

Dr. Dwight Jennings: A Live Look at Bite Realignment & How TMJ Impedes Performance #182

Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P.   Why you should listen –     In Part 1 of this 2-part podcast, Bulletproof Radio goes live inside Dr. Jenning’s office to discuss how bite alignment can impact everything from pregnancy and infertility, to migraines. head trauma sensitivity, symptoms of aging, and even erectile dysfunction, all while adjusting the contact points of Dave’s teeth and fixing his nocturnal bite guard. You’re definitely going to want to check out the video on this episiode, and don’t forget to check out Part 1! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Dec 201446min

Helen Irlen: Irlen Syndrome, & Visual Stimuli on Brain Performance – #181

Helen Irlen: Irlen Syndrome, & Visual Stimuli on Brain Performance – #181

Helen Irlen has over 40 years of experience as an internationally acclaimed researcher, educator, and therapist in treating visual perception problems. She has served as a professor of Psychology at Cornell, founder and Director of the Adult Learning Disabilities Program at California State University Long Beach, is listed in the Who’s Who in California, Asia and the Pacific Nations, and was named International Woman of the Year in 1999-2000. She has been featured in 60 Minutes (twice!), Good Morning America, BBC Special, ABC Worldwide News with Peter Jennings, and numerous other TV shows around the world talking about the Irlen Method and her patented Irlen Lenses.   Why you should listen –     Helen comes on Bulletproof Radio to discuss Irlen Syndrome, the side effects of LASIK, how technology and different visual stimuli impact brain performance, and how people can get tested for and treat problems with Visual Perception Disorder. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Dec 201421min

James Swanwick: Read a Book a Day, Give Up Alcohol, & Be an Alpha Male - #180

James Swanwick: Read a Book a Day, Give Up Alcohol, & Be an Alpha Male - #180

James Swanwick is an ESPN SportsCenter anchor, co-founder of Crocmedia, and the man behind the James Swanwick Show Podcast and The Alpha Male Club. James has been in print and TV journalism for over 20 years, and has been featured in the Associated Press, The Sun, Loaded Magazine, and many more newspapers and magazines. He authored the ebook Insider Journalism Secrets, and now teaches courses and provides coaching for aspiring journalists looking to break into the industry.   Why you should listen –     James comes on Bulletproof Radio to discuss how to read a book a day, why he gave up drinking alcohol 4 years ago, the difference between being good, excellent, and outstanding, and how to attract the kind of people that you want in your life. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Dec 201459min

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