Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1414)

Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P - #179

Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P - #179

Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P.   Why you should listen –     Dr. Dwight comes on Bulletproof Radio to discuss how bite alignment impacts the rest of the body, why jaw pain is a systemic functional health disorder, the difference between orthodontics and dental orthopedics and how to find a specialist that can properly help you with TMJ, and how you can upgrade overall physical performance by adjusting your bite and jaw alignment. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Dec 201455min

Jeffrey Smith: GMOs & Their Impact on Health - #178

Jeffrey Smith: GMOs & Their Impact on Health - #178

Jeffrey Smith is the founding executive director of The Institute for Responsible Technology, and one of the world’s foremost experts on the dangers of Genetically Modified Organisms (GMOs) and their impact on human health. Jeffrey directed the feature-length documentary, Genetic Roulette, which was awarded the Solari Report 2012 Movie of the Year, and the AwareGuide Transformational Film of the Year. He wrote the world’s best-selling book on GMOs, Seeds of Deception, as well as a book also titled Genetic Roulette, an authoritative work on GMO health dangers. Jeffrey has lectured in nearly 40 countries, has been featured in publications such as the New York Times, Washington Post, LA Times, and Time Magazine, and has appeared on BBC, NPR, and Fox News, among others.   Why you should listen –     Jeffrey comes on Bulletproof Radio to discuss the basics of genetic modification, the unknown effects of genetic engineering, how you can avoid GMOs, and what it will take in order to eliminate the GMO problem from the industry. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Dec 201454min

Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics - #177

Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics - #177

Dr. Grace Liu is renowned for the information she publishes on the blog, Animal Pharm, under the name “Dr. BG”. She is a Food and Nutritional Scientist and Functional Medicine Practitioner with a doctorate in Pharmacology, and one of the most knowledgeable people on the hot button topics of resistant starch (RS) and its effects on the health of the gut microbiome. She uses her expertise in the pharmaceutical world to explore the various scientific, nutritional, and pharmacological ins and outs of optimal health.   Why you should listen –     Hal comes on Bulletproof Radio to discuss the difference between resistant starch and regular starch, how resistant starch works in the body, how to prioritize the different testing methods for determining gut health, and the things you can do to start fixing your gut immediately. There is tons of in-depth information in this episode. Check out all of the resource links below. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Dec 201457min

Hal Elrod: Be Happier, Healthier, & More Productive - #176

Hal Elrod: Be Happier, Healthier, & More Productive - #176

Please pardon the poor quality of the audio and video, but the information Hal shared was far too valuable not to share!   Hal Elrod is a motivational speaker, success coach, and author of the #1 bestseller, The Miracle Morning. When he was 20, Hal was hit by a drunk driver going 70 mph, and was declared clinically dead for 6 minutes before recovering consciousness. Hal overcame medical logic by bouncing back to not only walk again, but to complete a 52-mile Ultra-marathon. He subsequently went on to become a record-breaking sales rep and national champion sales manager for Cutco, and eventually one of the most sought after keynote speakers in America before becoming a multiple time best-selling author. Hal has appeared on NBC’s Daytime, Fox News, and a host of other TV shows to share his incredible story, and the personal development secrets he has discovered for creating the life of your dreams.   Why you should listen –     Hal comes on Bulletproof Radio to discuss the 5-minute Rule for dealing with adversity, the difference between optimism and realism, the “miraculous” power or positive thought, and the importance of creating an amazing mornings success ritual. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Dec 201454min

Holli Thompson: Hack Into Your Nutritional Style - #175

Holli Thompson: Hack Into Your Nutritional Style - #175

Holli Thompson is the creator of Nutritional Style, a health and nutrition blog and consulting company, and author of the best-selling book, Discover Your Nutritional Style. Holli is a Certified Holistic Health Coach and Certified Natural Health Professional, a Myers Briggs Certified Practitioner, and a regular contributor to renowned health sites Mind Body Green, The Daily Love, and lesscancer.org. She has been featured on ABC’s Let’s Talk Live, on CBS, on The Daily Meal, and in USA Today, and the Huffington Post. Nutritional Style is all about recognizing that food is medicine, and the secret to living life in a beautiful, energized, healthful way. Why you should listen: Holli comes on Bulletproof Radio to discuss the cleansing, how to identify food allergies, the importance of making the connection between he foods you eat and the inflammation they cause, and how to discover your own Nutritional Style. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Nov 201438min

Brad Pilon: Eat Stop Eat & the Fundamentals of Intermittent Fasting - #174

Brad Pilon: Eat Stop Eat & the Fundamentals of Intermittent Fasting - #174

Brad Pilon is the author of Eat Stop Eat, and one of the top experts on the science of fasting, including the widely misunderstood protocol of intermittent fasting. Brad has a Master’s Degree in Applied Human Nutrition, and years of experience in the supplement industry as a Research Analyst and Development Manager. His personal blog, Eat Blog Eat, is a valuable resource for the research on fasting and information for how to optimize and troubleshoot fasting diet protocols, and his workout programs and books are designed to educate people on the truth about how to utilize fasting to achieve the results they want.   Why you should listen –     Brad comes on Bulletproof Radio to discuss the bodybuilder diet myth, the truth about women and intermittent fasting, the role of fasting on your gut microbiome, and why it’s important to understand total biological stress. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Nov 20141h 3min

Steven Kotler: Extreme Flow States for Humans & Dogs - #173

Steven Kotler: Extreme Flow States for Humans & Dogs - #173

Steven Kotler is an award-winning journalist and author of multiple New York Times Best-sellers, including The Rise of Superman and Abundance, and co-founder of the Flow Genome Project. Steven is one of the world’s foremost experts on flow states and human performance, and has been featured in leading publications such as TIME, Wired, Forbes, and the New York Times. He also authored A Small Furry Prayer, a book about the relationship between animals and humans that draws on his experience running an animal sanctuary, Rancho de Chihuahua.   Why you should listen –     This is a special in-person interview shot live from the 2014 Bulletproof Conference, where Steven was the keynote speaker! Steven comes on Bulletproof Radio to discuss the evolutionary origins of flow, why running an animal sanctuary helps him in other areas of life, how to trigger flow, and how you can increase performance by conquering fear and facing death. Enjoy the show!   Bulletproof Food Detective Download for iOS   Bulletproof Stress Detective Download for iOS See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Nov 201441min

Pedram Shojai: Origins & Adapting to the New Human Jungle - #172

Pedram Shojai: Origins & Adapting to the New Human Jungle - #172

Pedram Shojai is an acclaimed Doctor of Oriental Medicine, Qi Gong Master, herbalist, acupuncturist, and basically a certified badass. Pedram is an ordained minister in the Taoist tradition of Alchemy, and has studied yoga, meditation, Qi Gong, Tai Chi, Kung Fu, and healing for over 20 years. He uses his vast experience to teach audiences worldwide about philosophy, meditation, Qi Gong, healing, enlightenment, and the esoteric arts. His first documentary, Vitality, was released in 2012, and this year will mark the releases of his newest projects, a documentary called Origins, and a book titled Rise and Shine.   Why you should listen –     This is a special in-person interview shot live from the 2014 Bulletproof Conference! Pedram comes on Bulletproof Radio to discuss the re-calibration of your stress bucket, the importance of consciousness, the double-edged tool of technology, what it means to be a conscious consumer. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Nov 201438min

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