Biohacking News Weekly Update : 1351

Biohacking News Weekly Update : 1351

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.


This episode covers:


Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm


The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html


FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter


Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.html

Further reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/


Your Medical Avatar Is Coming — The Digital Twin of You

Forbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.

Source: Forbes Innovation — https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/


This is essential listening for fans of biohacking, human performance, functional medicine, and longevity sciencewho want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.


With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.


New episodes drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.


Keywords: vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foods, biohacking news, medical avatar, digital twin, predictive medicine, Daniel Kraft, quantum health, wearable AI, Dave Asprey, The Human Upgrade


Thank you to our sponsors!

TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.

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Timestamps:

0:00 — Introduction

0:18 — Story 1: Vitamin D & Telomeres

1:02 — Story 2: Longevity Gene Therapy

1:49 — Story 3: FDA Supplement Reform

2:38 — Story 4: Gut Bacteria & Autophagy

3:46 — Story 5: Medical Avatars

4:53 — Weekly Protocol

5:42 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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#104 The Science of Smart with Dan Hurley

#104 The Science of Smart with Dan Hurley

Is it all just a bunch of “happy talk” or is it true that with focused brain training, we can all get smarter? Science journalist and author, Dan Hurley comes on Bulletproof Radio to talk about the science of smart and fluid intelligence. Find out what that is and if/how it can be increased for individuals. Everyone wants to be smarter and science is coming up with new ways to make it possible. Hurley is an expert on what we can do to hack our brain and make it work smarter. On the show you’ll hear about things like working memory, Dual-N-Back training, how IQ is different from fluid intelligence, and if pre-school actually helps make us smarter. Dual-N-Back is talked about a lot on Bulletproof Radio. Visit the link to soakyourhead.com in the show notes and try it out!     Dan Hurley is an award-winning science journalist whose 2012 feature in The New York Times Magazine, “Can You Make Yourself Smarter?”, was one of the magazine’s most-read articles of the year. Featured in the 2013 PBS documentary feature, “Smarter Brains,” Dan has written on the science of increasing intelligence for the Washington Post and Neurology Today. His previous book, Diabetes Rising, was excerpted in Discover and Wired. He has written nearly two dozen articles for the New York Times since 2005. These days Dan still occasionally writes 60-Second Novels at special events around the United States. Maybe that's what keeps him smarter? See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Mars 201454min

#103 Dr. Susanne Bennett Uncovers Upgraded Skin Care

#103 Dr. Susanne Bennett Uncovers Upgraded Skin Care

An average adult's skin spans 21 square feet, weighs nine pounds, and contains more than 11 miles of blood vessels. As the largest human organ, having abnormal skin conditions are not only socially embarrassing, but are more often than not an indication of a problem occurring inside of the body. On episode 103 of Bulletproof Radio, skin expert Dr. Susanne Bennett tells you how to hack into your skin and make it better and ultimately, how to look as great on the outside as you feel on the inside. Discover how allergic reactions to food and environmental toxins often result in unsightly skin problems, the benefits that topical supplements like collagen and glutathione can bring you, and an all new way to use your coffee grounds. Oh! And Dave talks about poop again on the show. It turns out that poop really matters in skincare too! And listen up for details on a stellar discount for an upgraded skincare product! Enjoy.   Dr. Susanne Bennett, D.C., CCSP, is the founder of the Wellness For Life Center in Santa Monica, California. She specializes in allergies, clinical nutrition, environmental and lifestyle medicine, with an emphasis in pediatric and young adult health care. She is the creator and author of The 7-Day Allergy Makeover (Penguin, March 2014), a step-by-step clinically proven program that helps individuals break free from their allergy symptoms by utilizing natural therapies and solutions without drugs or injections. Her passion is to be of service as a lifestyle medicine expert and provide cutting edge natural health practices to facilitate optimal healing, vitality and vigor.   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Mars 201449min

#102 – Extreme Endurance Training and Ketosis with Ben Greenfield

#102 – Extreme Endurance Training and Ketosis with Ben Greenfield

The days of eating bananas and oatmeal before a race are over. Nowadays extreme endurance athletes are finishing Ironmans (and the like) in ketosis. Enter top competitor, performance trainer, and hardcore biohacker, Ben Greenfield. On this episode of Bulletproof Radio, Dave and Ben discuss many things ketosis, increasing mitochondrial density, and the fine line between moving your body for optimal performance and chronic cardio. The show will also expose Ben’s upgraded protocol for staying in a state of ketosis while training for Ironman competitions. There’s a ton of useful information to take note of here. Check out the show notes for links and resources!     Ben Greenfield is a coach, author, speaker, ex-bodybuilder and Ironman triathlete. His science-based approach to discovering a potent balance between health and performance has revolutionized the way thousands of athletes and exercise enthusiasts around the world live, train and eat. Ben now works with athletes, CEO’s and soccer moms from around the world to achieve amazing feats of physical endurance without destroying their body in the process. Follow him on Twitter at @bengreenfield. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Mars 201452min

#101 – Mark Sisson on the Primal Blueprint

#101 – Mark Sisson on the Primal Blueprint

Mark Sisson is a fat burning beast and one of prime authorities in the Paleo-sphere today. On this episode of Bulletproof Radio, Mark talks about the concepts behind his top-performing book, The Primal Blueprint, and how they relate to a Bulletproof lifestyle. Have you ever looked at your body as its own life support system for ancient bacteria colonies? You’ll also hear about epigenetics, lectins, and how to get low-tech with a shit milkshake?  He’s articulate, full of upgraded knowledge, and has kick ass abs. Please enjoy!     Mark Sisson is the author of a #1 bestselling health book on Amazon.com, The Primal Blueprint, as well as The Primal Blueprint Cookbook and the top-rated health and fitness blog MarksDailyApple.com. He is also the founder of Primal Nutrition, Inc., a company devoted to health education and designing state-of-the-art supplements that address the challenges of living in the modern world. In his own words: “My life has been one built around health and fitness and I don't plan for that to ever end. I've made it my personal goal to help 10 million people achieve their ultimate genetic potential.” See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Mars 201457min

#100 Coffee Titan Dan Cox on Caffeine, Coffee, and Mycotoxins – Podcast

#100 Coffee Titan Dan Cox on Caffeine, Coffee, and Mycotoxins – Podcast

After more than two years The Bulletproof Executive Podcast has reached its 100th episode! And who better to have as a guest for this milestone than coffee titan and caffeine-expert, Dan Cox? If there is anyone alive today that can spit coffee talk more articulately or with more authority, we’d like to hear from him or her. Dan’s historical knowledge of coffee-for-consumption is unrivaled and his grasp of coffee culture today is paramount in the industry. In our centennial episode you will discover things abut coffee that I bet you didn’t know, like: the amount of effort it takes to test for mycotoxins in coffee, the current state of coffee brands in America, and what the future of our coffee consumption looks like. This old-school coffee mafia knows his stuff and presents a refreshingly humble take on these little seeds that make such a big impact on our lives. Thanks for listening and cheers to 100 more episodes!     Dan Cox is the Owner and President of Coffee Enterprises and a connoisseur of all things coffee. He was one of the first American’s to pass the rigorous Q Grader Exams of which there are only 1,000 worldwide. Dan is a leading authority on the Specialty Coffee Industry and brings to bear 32 years of practical experience in management, roasting, cupping, product development, and marketing. He received the prestigious honor of a Lifetime Achievement Award from the Specialty Coffee Association of America, and is also the Founder and President of Grounds for Health, a nonprofit bringing health care to women in coffee producing countries. He is a coffee titan like no other, although he would never agree with the designation.    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Feb 201455min

#99 Working Smarter Not Harder with Ari Meisel

#99 Working Smarter Not Harder with Ari Meisel

Work smarter, not harder! You’ve probably heard this sentiment before in one-way or another. But what does it really mean, and is it actually possible to be more successful by doing less? Ari Meisel is the creator of Less Doing, a strategy to be able to do less and live more. Happy to have Ari back on Bulletproof Radio, he joins the podcast this time to talk about his forthcoming book, Less Doing, More Living and how he beat Crohn’s disease. Listen to the show and discover how to get things done better by creating the manual of you. You’ll also hear how to optimize your haircut. Enjoy!     In 2006, Ari Meisel was diagnosed with Crohn’s disease an incurable inflammatory disease of the digestive tract. His case was severe, and required over a dozen daily medications and several hospital visits. After reaching a personal low point in hospital, Meisel decided to take control of his own health and fix his then weakened body. With a focus on nutrition, supplementation, and exercise Ari was eventually declared free of all traces of the ‘incurable’ disease, and competed in Ironman France in June of 2011. Through the process of data collection, self-tracking, and analysis, Ari developed Less Doing. This was a way of dealing with the daily stresses of life by optimizing, automating, and outsourcing tasks in life and business. Today Ari focuses on Achievement Architecture, helping individuals be more effective at everything and advising several companies. Today Ari resides in Bridgehampton, NY with his wife Anna, three sons Benjamin, Sebastien, and Lucas, and two dogs Sylvain and Oscar. Follow him on Twitter at @arimeisel. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Feb 201444min

#98 Transforming Lives with Light and Helen Irlen

#98 Transforming Lives with Light and Helen Irlen

Any Hollywood movie star will tell you that lighting is ‘everything’ when it comes to looking great and performing well. But lighting is so much more than just looking good on camera – it affects your mental performance in a major way. Today’s podcast guest, Helen Irlen, is dedicated to getting the word out about visual health and how to optimize your performance by identifying your particular lighting requirements. On the show Helen talks about the Irlen Method and why the science of color transforms lives! Ever wonder what those funny-looking glasses are that Dave wears all the time? Discover what they are and why he wears them on this episode of Bulletproof Radio!     Helen L. Irlen is an internationally recognized educator, researcher, therapist, scholar, and expert in the area of visual-perceptual problems. She is a graduate of Cornell University. Ms. Irlen has been in the field of education for the past 40 years. Her background includes 15 years as a School Psychologist, 30 years as a Child and Family Therapist, Educational Therapist, founder and director of the Adult Learning Disabilities Program and Assistant Professor of Adult Learning Disabilities at California State University/Long Beach, instructor in psychology at Cornell University, and research assistant at Cornell. Because of this breakthrough, the Irlen Method has been the subject of two segments of 60 Minutes, Good Morning America, The Home Show, 60 Minutes Australia, a BBC Special, ABC Worldwide News with Peter Jennings, NBC News, and numerous TV shows around the world.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Feb 201444min

#97 Biohacking Your Impact with Anese Cavanaugh

#97 Biohacking Your Impact with Anese Cavanaugh

When was the last time you were consciously aware of how others perceive you in the world? Take a second and consider how biohacking your impact can improve performance. It’s not all tie-die and patchouli (although we love tie-die and patchouli), this stuff is based in science and it works. IEP Method creator, Anese Cavanaugh, comes on Bulletproof Radio to talk intentional energetic presence, and why not to be a professional bummer. You’ll discover the science behind IEP and how to boost your energetic presence. You’ll also learn why a great reason for having good hygiene. Dig in and be present!     Anese Cavanaugh is a mom, entrepreneur, writer, speaker, and all-around leadership and collaboration expert. She is the creator of the IEP Method and Craft Impact Program. Anese is considered a trusted advisor, teacher, and thinking partner to some of today’s most savvy business leaders and organizations like IDEO, Cooper, Chevron, IBM, Doorsteps, Citicorp, and others. Anese has been seen in Shape Magazine, Prevention Magazine, the Miami Herald, Western Suburban, TNG, Leadership Digital, Inc Small Giants, and on stages across the country. She swears by self-care, purpose, and impact; is obsessed with Bikram Yoga, cross training, and Bulletproof Coffee; delights in partnership and being a mom to 2, and currently splits her time between San Francisco, New York City, and Sacramento. You can tweet her at @anesecavanaugh. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Feb 201454min

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