#140: How Real-World Evidence Is Shaping the Future of Multiple Sclerosis Treatment – Highlights from ECTRIMS 2025

#140: How Real-World Evidence Is Shaping the Future of Multiple Sclerosis Treatment – Highlights from ECTRIMS 2025

In this episode, I take you behind the scenes of ECTRIMS 2025 and explore seven fascinating studies that show how multiple sclerosis (MS) care is evolving — from safety monitoring and infection risks to data-driven, personalized treatment decisions.

You'll learn about:

  • How often late-onset neutropenia occurs in people on Rituximab and who's most at risk.

  • What factors increase the chance of serious infections with Ocrelizumab.

  • Why early high-efficacy treatment leads to better long-term outcomes across four countries.

  • What happens to memory B cells during long-term Ocrelizumab therapy and what that means for extended dosing intervals.

  • What the FAERS database tells us about tumor signals and why HPV vaccination remains essential for women with MS.

  • How real-world data from the TEMPOS study (France) reveal a massive shift toward anti-CD20 therapies — especially Ofatumumab.

  • And finally, how a new AI-based prediction tool helps estimate individual risk when stopping a DMT.

🎯 Main takeaway: MS treatment is moving toward earlier, stronger, and more personalized approaches — guided by real-world evidence and smart technology.

👉 You can read the full article with all study details, numbers, and takeaways here: https://ms-perspektive.de/en/140-ectrims-rwe

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See you soon and try to make the best out of your life,
Nele

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#178: Tai Chi and Qigong for MS: Supporting Balance, Movement and Body Awareness – Interview with Mirko Lorenz

#178: Tai Chi and Qigong for MS: Supporting Balance, Movement and Body Awareness – Interview with Mirko Lorenz

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#177: A First Diagnosis of Multiple Sclerosis: Symptoms, Tests, and Next Steps

#177: A First Diagnosis of Multiple Sclerosis: Symptoms, Tests, and Next Steps

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#176: Progressive MS Research: Milestones, Setbacks and Hope with Tim Coetzee

#176: Progressive MS Research: Milestones, Setbacks and Hope with Tim Coetzee

Progressive MS research has made important advances, but many questions about disability progression, biomarkers, treatment, and quality of life remain unanswered. In this episode, I speak with Tim Co...

22 Juli 56min

#175: Multiple Sclerosis and Pain. How Exercise and Physical Activity Can Help

#175: Multiple Sclerosis and Pain. How Exercise and Physical Activity Can Help

Pain is one of the most common and life-impacting symptoms in multiple sclerosis. In this episode, Nele talks with Rasmus Christian Jungersen, PhD student at the Department of Exercise Biology at Aarh...

15 Juli 1h 8min

#174: MS Treatment Access in Australia. Deanna and Rachel on Living with Multiple Sclerosis, Advocacy, and the Future of Ocrevus, Kesimpta & Briumvi

#174: MS Treatment Access in Australia. Deanna and Rachel on Living with Multiple Sclerosis, Advocacy, and the Future of Ocrevus, Kesimpta & Briumvi

Deanna Renee and Rachel Kerr speak about living with multiple sclerosis in Australia, the importance of lived experience in policy, and the current uncertainty around PBS access to Ocrevus and Kesimpt...

8 Juli 41min

#173: Immunoadsorption for MS Relapses. Interview with senior physician Anna-Katharina Eser

#173: Immunoadsorption for MS Relapses. Interview with senior physician Anna-Katharina Eser

In this episode, I speak with Anna-Katharina Eser, senior physician at the MS Centre in Mainkofen, Germany, about immunoadsorption in multiple sclerosis. Immunoadsorption is a specialized blood purifi...

1 Juli 15min

#172: AI for MS. How the CLAIMS Project Could Transform MS Care – with Prof. Friedemann Paul

#172: AI for MS. How the CLAIMS Project Could Transform MS Care – with Prof. Friedemann Paul

In this episode, Prof. Friedemann Paul from Charité – Universitätsmedizin Berlin, Germany, explains how the European CLAIMS project aims to improve multiple sclerosis care through AI-assisted decision...

24 Juni 35min

#171: The Gut-Brain Axis in Multiple Sclerosis. Interview with Prof. Dr. Anne-Katrin Pröbstel

#171: The Gut-Brain Axis in Multiple Sclerosis. Interview with Prof. Dr. Anne-Katrin Pröbstel

The gut–brain axis in multiple sclerosis is an exciting field of research that connects the gut microbiome, immune system and central nervous system. In this interview, Prof. Dr. Anne-Katrin Pröbstel ...

17 Juni 19min

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