10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Ozone Therapy & Medical Freedom with Robert Rowen

Ozone Therapy & Medical Freedom with Robert Rowen

Today from the Bulletproof Radio vaults comes an episode with "The Father of Medical Freedom," Dr. Robert Rowen. Dr. Rowen pioneered the nation's first law protecting alternative medicine, and uses ozone therapy to treat a host of different ailments. At the time of this interview, Dr. Rowen was fresh off of a visit to Africa to provide treatment during the Ebola epidemic. Listen to Dave and Dr. Robert Rowen talk about ozone therapy, using ozone at home, Ebola and ozone, oxygenation therapy and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Okt 201647min

Hacking Addiction with Dr. Mark

Hacking Addiction with Dr. Mark

Addiction manifests itself in many ways, and therefore there's a lot of different approaches to fighting it. On this episode of Bulletproof Radio, Bulletproof Coach Training leader Dr. Mark Atkinson and Dave give their insight into the best ways to combat and hack addiction of all types. Dave and Mark talk about heroin and prescription drugs, alcohol, pornography, information addiction, fear of missing out and more. Enjoy the show. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Okt 20161h 6min

Hacking Your Relationship with Food -  Jonathan Bailor

Hacking Your Relationship with Food - Jonathan Bailor

Today from the Bulletproof Radio vaults comes a great episode with SANESolution founder Jonathan Bailor. SANESolution guides you to the right foods to help you burn off fat. In addition to SANESolution, Jonathan is a radio host, blogs for the Huffington Post, and is the author of the bestselling book The Calorie Myth. Dave and Jonathan talks about SANE Solutions, a new way to understand your food, why quality over quantity is important, and why calorie counting doesn't work. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Okt 201655min

The Do's & Don'ts of Light Hacking

The Do's & Don'ts of Light Hacking

On today's episode of Bulletproof Radio, Dave goes solo shooting on the topic of light hacking and light therapy. Dave shows off a ton of his Bulletproof Labs light gear too, so check out this episode's YouTube video! Hear Dave's feedback on halogen lights, lasers, ultraviolet A and B light, nitric oxide, Irlen Syndrome and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Sep 201652min

Fasting & Feasting with Brad Pilon

Fasting & Feasting with Brad Pilon

Today from the Bulletproof Radio archives comes an episode with Eat Stop Eat author Brad Pilon. Brad has a Master's Degree in Applied Human Nutrition, and years of experience in the supplement industry as a Research Analyst and Development Manager. His personal blog, Eat Blog Eat, explores intermittent fasting and is a valuable resource for anyone getting into fasting. His workout programs and books are designed to educate people on the truth about how to utilize fasting to achieve the results they want. On this episode of Bulletproof Radio, Dave and Brad discuss the bodybuilder diet myth, the truth about women and intermittent fasting, the role of fasting on your gut microbiome, and why it's important to understand total biological stress. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Sep 20161h 5min

Clone Wars with Gregory Pence

Clone Wars with Gregory Pence

Dr. Gregory Pence is a premier academic expert on ethics of cloning humans, even testifying to Congress on the matter. He has a 40-year career in bioethics, and taught it in medical school for 34 years. Dr. Pence is a huge fan of the Emmy Award-winning television show Orphan Black, and discusses the show, cloning and other aspects of bioethics in his book, "What We Talk About When We Talk About Clone Club." On this episode of Bulletproof Radio, Gregory and Dave talk about Dolly the cloned sheep, CRISPR, bioethics, the different types of cloning, scientific assumptions, the future of cloning legality and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Sep 20161h 16min

Get and Stay Charming with Jordan Harbinger

Get and Stay Charming with Jordan Harbinger

Today from the Bulletproof Radio archives comes an episode with Art of Charm podcast host Jordan Harbinger. Jordan was entering the world of Wall Street when he learned the value of being a confident, charming person. Rather than toiling away with technical work, he started the Art of Charm podcast to teach confidence and the rest is history. Listen to Jordan and Dave talk about Jordan's path, training yourself to be confident, urban escape, the Art of Charm for women, relationship tips and more. Enjoy the show! This is the first of a weekly series where we're releasing remastered versions of some of our best episodes you might not have heard yet. Fridays will continue to have great new guests! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Sep 20161h 4min

Rocking the Pain in Your Neck with Billy DeMoss

Rocking the Pain in Your Neck with Billy DeMoss

Dr. Billy DeMoss is the founder of the Dead Chiropractic Society, a coalition of Southern California chiropractors who meet monthly to discuss chiropractic philosophy and advancements. He expanded DCS in 2008, when he created California Jam. The Cal Jam conference invites world-renowned experts in public health and global sustainability to educate and empower people who find natural solutions more attractive than harmful man-made ones, and Dave will be a keynote speaker at the conference in 2017. Dr. Billy also heads his own innovative practice. On today's episode of Bulletproof Radio, Dave and Billy talk about nerve function, the spine, vaccines, drug use, music, recognizing a good chiropractor and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Sep 201658min

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