10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Avsnitt(1430)

Tony Wrighton - Neurofeedback, Decluttering & Alpha State: #286

Tony Wrighton - Neurofeedback, Decluttering & Alpha State: #286

Tony Wrighton is the host of top-rated podcast Zestology, where he interviews a wide range of experts in the field of health and personal development. He also regularly appears as a guest on other shows talking about energy, vitality, and motivation. Tony has been a presenter on Sky Sports since 2006 and is a regular on Sky Sports News HQ. He's embraced the Bulletproof lifestyle and joins Dave today on Bulletproof Radio to talk about neurofeedback, bluetooth radiation, controlling inner voice, stress and language hacks, using NLP and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Feb 20161h 5min

Jason Silva - Brain Games, Transhumanism & Your Ego: #285

Jason Silva - Brain Games, Transhumanism & Your Ego: #285

Jason Silva is the host of National Geographic Channel's #1 rated and Emmy-nominated series, Brain Games. Jason gives viewers the "why" behind the "wow," through a series of man-on-the-streets and experiments, and is joined by top experts in the fields of cognitive science, neuroscience and psychology. On this episode of Bulletproof Radio, Dave talks to Jason about Kolbe scores, transhumanism, Brain Games experiments, reincarnation, the ego and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Feb 20161h

Abel James - My Diet Is Better Than Yours: #284

Abel James - My Diet Is Better Than Yours: #284

Abel James is a best-selling author, entertainer, lifestyle entrepreneur and great friend of Bulletproof Radio. He's been featured in People Magazine, WIRED, and USA Today, and has the award-winning web series, Fat-Burning Man. This winter Abel starred on ABC's My Diet is Better Than Yours, as a trainer to one of the show's most successful contestants. Abel returns to Bulletproof Radio today to talk with Dave about his diet, appearing on TV, Irlen lenses, adult coloring books, the benefits of fat-heavy diets and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Feb 201653min

Pedram Shojai - The Urban Monk: #283

Pedram Shojai - The Urban Monk: #283

Pedram Shojai is a former Taoist monk and an accomplished physician of Chinese medicine. He is the founder of Well.org, a documentary filmmaker and an author of two books including the recently penned work The Urban Monk. A Bulletproof Radio regular, Pedram stops by today to talk with Dave about productivity boosters at work, time-management, science skeptics, standing desks, capitalism and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Feb 201654min

Neil Strauss - Situational & Behavioral Awareness: #282

Neil Strauss - Situational & Behavioral Awareness: #282

Neil Strauss is a New York Times best-selling author of seven books, including The Game and Rules Of The Game, for which he went undercover in a secret society of pickup artists for two years. In the years since, Neil has completely revamped his perceptions on relationships, detailed in his latest book, The Truth. On this episode of Bulletproof Radio, Dave and Neil talk about the pickup artist scene and the reasons behind it, situational awareness, willpower and beliefs, EMDR treatment and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Feb 201652min

Andy Hnilo - Entrepreneurship & Alitura Naturals: #281

Andy Hnilo - Entrepreneurship & Alitura Naturals: #281

Andy Hnilo is a familiar face on Bulletproof Radio. The model, actor, and fellow biohacking geek has appeared on the show two times in addition to today, telling the story of his incredible car-accident recovery and how it led to his skincare business Alitura Naturals. On this episode of Bulletproof Radio, Dave and Andy talk about tips for having great skin, advice for growing a business, personal diets and routines, motivation, customer service and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Feb 20161h 3min

Alberto Villoldo - Shamanism & Energy Fields: #280

Alberto Villoldo - Shamanism & Energy Fields: #280

Alberto Villoldo, Ph.D., is a medical anthropologist and psychologist who studied the shamanic healing practices of the Amazon and the Andes for more than 25 years. He is the founder of the Four Winds Society, which teaches the philosophy and practice of energy medicine. This is Dr. Villoldo's third appearance on Bulletproof Radio. On today's episode, Dave and Alberto talk about pineal glands, fate and destiny, Shamanic teachings, the fight-or-flight response, placebo effects and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Feb 20161h 3min

Daymond John: Financial Intelligence & Learning from Failure - #279

Daymond John: Financial Intelligence & Learning from Failure - #279

Daymond John is CEO and founder of FUBU, a much-celebrated global lifestyle brand with more than $6 billion in sales. As one of the stars of ABC's Shark Tank, Daymond is one of the country's most visible and well respected entrepreneurs. On this episode of Bulletproof Radio, you'll hear Daymond talk about creating FUBU, his successes and failures, being a mentor, financial intelligence, his experiences on Shark Tank and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Jan 201651min

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