10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Avsnitt(1425)

Steve Omohundro Talks Technology for a Better World – Podcast #134

Steve Omohundro Talks Technology for a Better World – Podcast #134

Steve Omohundro is a scientist, professor, author, software architect, and entrepreneur doing research on natural and artificial intelligence. He has degrees in Physics and Mathematics from Stanford and a Ph.D. in Physics from U.C. Berkeley.   On this episode of Bulletproof Radio, tune in to discover the secret to Steve’s weight loss breakthrough, why Dave fired his doctor, and how you should define artificial intelligence. You’ll also hear about mycotoxins, transhumanism, and non-violent communication. There are a ton of resources below, be sure to check them out! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Juli 201453min

Arianna Huffington is Thriving – Podcast #133

Arianna Huffington is Thriving – Podcast #133

Arianna Huffington is one of the most influential and iconic women in the world. Arianna has been named to both TIME Magazine's 100 Most Influential list and Forbes' "The World's 100 Most Powerful Women" list, and her Pulitzer Prize-winning blog, The Huffington Post, is read by more than 43 million people worldwide every month! She is the author of 14 books, including Arianna’s latest book Thrive, which debuted at #1 on the New York Times Bestseller List. Arianna joins this episode of Bulletproof Radio, to discuss the inspiration behind it and: ·         The three metrics of success ·         Start-up company culture ·         Women and stress   ·         Epigenetics, and tons more!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Juli 201447min

Gain Control of Your Biochemistry with William J. Walsh, Ph.D. – Podcast #132

Gain Control of Your Biochemistry with William J. Walsh, Ph.D. – Podcast #132

Gaining control of our minds, bodies, and life is what biohackers do in order to perform our best. In this show the notable Dr. William Walsh of the Walsh Research Institute uncovers the knowledge he’s gained after over 30 years of researching human biochemistry. You’ll hear about: ·         Engineering the human chemistry ·         Trace metals ·         Dr. Walsh’s work with ex-convicts ·         The power of nutrients ·         Depression ·         Epigenetics ·         Blood testing ·         And even Dr. Walsh’s theory on school shootings.   All this and more on episode #132 of Bulletproof Radio!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Juli 201436min

Supercharge Your Skin with Alitura Naturals - Podcast #131

Supercharge Your Skin with Alitura Naturals - Podcast #131

This episode of Bulletproof Radio features the makings behind the first ever Bulletproof® Approved skin care product available on UpgradedSelf.com: The Alitura Clay Mask. This mask is the ultimate formulation of thousand year-old skin care techniques and the latest technology. You will hear how Bulletproof Ambassador Andy Hnilo created the upgraded formula, the secret behind the ingredients, and how using it can give reveal amazing skin.     Andy Hnilo recovered from a hit-and-run car accident as a pedestrian and used Bulletproof® Diet and supplements to recover. As a professional model and actor Andy’s career was on the line and this drove him to passionately create a new skin care line using clays for detox and nourishing elements of Grass-Fed Collostrum as well as Freshwater Pearl Powder. You won’t find this unique combination anywhere else and Bulletproof is proud to support Alitura Naturals. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Juni 201448min

Bulletproof Radio Q&A #130

Bulletproof Radio Q&A #130

On this episode of Bulletproof Radio, we have carefully selected the best questions from Facebook, Twitter, and the Bulletproof® Forums for another awesome Q&A!  Thanks to you, the listener! Hear a thought-provoking conversation and gain a ton of useful knowledge in this episode about the art of biohacking, nutrition, and… well… kicking ass at life in general! Dave and Zak talk about supplements and how they affect the gut, what they feed their kids, how to be Bulletproof® on a budget, and why grass fed butter is way better for you than raw crème in your Bulletproof® Coffee (not to mention ten times cheaper too!). It’s been a while since the last Q&A and we’re sorry, but please enjoy the show!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Juni 20141h 11min

Sleeping for Performance with Neurotechnology - Podcast #129

Sleeping for Performance with Neurotechnology - Podcast #129

Sleep experts Dr. Phillip Westbrook, M.D. and Clinical Professor of Medicine at UCLA, and Dan Levendowski, Co-founder of Advanced Brain Monitoring (ABM) come on Bulletproof Radio to uncover the foundation for how to hack your sleep using the latest cutting-edge technology. Levendowski shares his personal story of using this technology to confirm that he was waking up 70 times per hour because of sleep apnea. Also hear about optimal sleep positions, how obesity causes sleep problems, and why getting kicked by your spouse when you snore is a good thing.     Aside from being the co-founder of ABM, Dan Levendowski is a serial inventor who has spearheaded the development of numerous disruptive medical technologies. He has also served as principal investigator for 17 National Institute of Health research grants managing over $8 million in funding for research in chronic disease, physiology, and performance optimization. He has co-authored more than 20 journal articles and 15 papers for new product adoption and has an award winning winery. Dr. Phillip Westbrook has had an extensive career as a medical physician specializing in pulmonary disease and physiology. Dr. Westbrook has presented over 100 guest lectures to professional organizations, was Editor-in-Chief of the Sleep Medicine Review, an editor for Sleep, a guest reviewer for Chest and an Ad Hoc reviewer for The New England Journal of Medicine.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Juni 201451min

#128 Andy Hnilo and Skin Care – Special Episode

#128 Andy Hnilo and Skin Care – Special Episode

Today’s episode of Bulletproof Radio is short and sweet, but packed full of Andy Hnilo. Andy is a model and actor who had a life-changing car accident leading him to create a skin care line that he personally used to heal his injuries and detox his skin. You will also hear him share the science behind clay and how you can combine these age-old techniques with new ones to improve sleep and sex. Stay tuned for a full episode with Andy where he talks more in-depth with Dave about Alitura Naturals and the benefits of clay.     Andy had a life-changing event when he was run over by two SUV’s that left him with his jaw wired shut and injuries all over his body. This event transformed him and drives his passion to share his new skin care line Alitura Naturals. Enjoy the show.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Juni 201416min

#127 Tim Ferriss on Smart Drugs, Performance, and Biohacking

#127 Tim Ferriss on Smart Drugs, Performance, and Biohacking

Okay so it’s not really a 4-hour show (this time), but it is heavy nonetheless. The 4-Hour man himself, Tim Ferriss, is on Bulletproof Radio to unleash his biohacking expertise and to share some knowledge. Tim has a new podcast called The Tim Ferriss Show and on this episode of Bulletproof Radio you hear him on the other side of the mic talking about his view on smart drugs, tea as a creative stimulant, eating insects, and how sex is better than porn for your biochemistry.     The 4-Hour Workweek, The 4-Hour Body, and The 4-Hour Chef have been #1 New York Times bestsellers and Tim Ferriss has been listed as one of the most Most Innovative Business People and a Forbes Magazine “Names You Need to Know”. He is a biohacker and self-experimenting guinea pig. His blog The Four-Hour Blog chronicles his never-ending quest for self-improvement and shares a wealth of information. Enjoy the show. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juni 201442min

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