10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1425)

3 Experts Reveal the Secrets to Optimizing Your Nutrition : 1201

3 Experts Reveal the Secrets to Optimizing Your Nutrition : 1201

In this "Best of Nutrition" episode, 3 experts in nutrition share powerful insights on improving your health and performance through optimal eating habits. Listen in as Dr. Mark Hyman, Andrea Bemis, and Shawn Stevenson provide practical tips on boosting energy, improving digestion, and choosing nutrient-dense foods to help you feel your best. Dr. Mark Hyman, a leading expert in functional medicine, dives deep into the importance of nutrient-dense foods and traditional cooking oils like ghee and olive oil. He shares his insights on how these healthy fats support brain health, metabolism, and overall well-being, especially in children. Learn how simple dietary changes can have a significant impact on health. Shawn Stevenson, best-selling author and host of The Model Health Show, breaks down the role of nutrition in optimizing performance and mental clarity. He highlights the science behind choosing the right foods to fuel your body and mind, offering practical tips for enhancing energy and building a sustainable healthy lifestyle. Andrea Bemis, author and advocate for regenerative agriculture, explores how the way we source and grow our food directly affects nutrient quality. She discusses the importance of eating seasonally and locally, providing valuable insights on how to incorporate farm-fresh foods into everyday meals to nourish your body and support the environment. CHECK OUT THE FULL EPISODES NOW! Dr. Mark Hyman: https://youtu.be/TcEgBrfT8LI Shawn Stevenson: https://youtu.be/J2Tq_2Bawig Andrea Bemis: https://youtu.be/bFCASBNah0w Sponsors: Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: Mark Hyman’s Website: https://drhyman.com Mark Hyman’s Instagram: @drmarkhyman Andrea Bemis’s Website: https://dishingupthedirt.com Andrea Bemis’s Instagram: @andreabemis Shawn Stevenson’s Website: https://themodelhealthshow.com Shawn Stevenson’s Instagram: @shawnmodel Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ Timestamps and Highlights: 00:00:00 — Introduction by Dave Asprey 00:01:58 — Dr. Mark Hyman on Cooking Oils 00:04:04 — Feeding Kids Nutrient-Dense Meals 00:07:16 — Efficient Cooking and Eating with Kids 00:11:27 — Introducing New Foods to Children 00:12:56 — Listening to Kids’ Intuitive Eating Signals 00:14:28 — Salt in Children's Diets 00:22:32 — Regenerative Agriculture and Nutrient Density 00:31:28 — Finding High-Quality Foods See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Sep 20241h 4min

3 Experts Reveal the Secrets to Gut Health : 1200

3 Experts Reveal the Secrets to Gut Health : 1200

In this episode of The Human Upgrade, gut health experts Dr. Steven Gundry, Dr. Edward Group, and Hannah Kleinfeld share groundbreaking insights into the gut microbiome, detoxification, and the impact of fermented foods on digestion. Discover how caring for your gut can enhance your energy, brain health, and immunity. Check out the Full Episodes here: Dr. Steven Gundry: https://youtu.be/SpO6k9Ofh2E Hannah Kleinfeld: https://youtu.be/zFKHJIX8vtM Dr. Edward Group: https://youtu.be/GV2KnL0wW9M Sponsors: Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: Dr. Steven Gundry's Book, Gut Check: https://drgundry.com Dr. Steven Gundry's Podcast: https://drgundry.com/the-dr-gundry-podcast/ Dr. Steven Gundry’s Instagram: @DrGundry Dr. Steven Gundry's Facebook: Dr. Steven Gundry Global Healing by Dr. Edward Group: https://globalhealing.com Global Healing Instagram: @globalhealingofficial Dr. Edward Group Instagram: @drgroupofficial Omni-Biotic: https://omnibioticlife.com Instagram: @omnibioticlife Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ Timestamps and Highlights: 00:01:00 — Introduction to Gut Health and Parasites with Dr. Steven Gundry 00:06:00 — Fermented Foods & Gut Health with Hannah Kleinfeld 00:12:30 — Probiotics and Detox with Dr. Edward Group 00:18:00 — Practical Steps for a Healthier Gut See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Sep 20241h 1min

Natural Ways to Prevent Alzheimer's and Boost Brain Health with Dr. Heather Sandison : 1199

Natural Ways to Prevent Alzheimer's and Boost Brain Health with Dr. Heather Sandison : 1199

In this episode of The Human Upgrade, Dave Asprey and Dr. Heather Sandison discuss actionable strategies for optimizing brain health and longevity. Dr. Sandison explains how lifestyle changes, including diet, oral hygiene, and sleep, can help prevent cognitive decline. She also shares insights into the Marama Experience, her revolutionary approach to memory recovery and brain health. Sponsors: Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: Dr. Sandison’s Website: www.drheathersandison.com Reversing Alzheimer’s Book: https://reversingalzheimersbook.com Dr. Sandison’s Facebook: https://www.facebook.com/HeatherSandisonND Dr. Heather Sandison’s Instagram: https://www.instagram.com/dr.heathersandison/ Dr. Sandison’s TikTok: https://www.tiktok.com/@drheathersandison Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ Timestamps and Highlights: 00:00:01 – Introduction by Dave Asprey 00:02:30 – The Role of Diet in Brain Health 00:07:00 – The Importance of Oral Health in Brain Function 00:12:00 – How Sleep Impacts Cognitive Health 00:17:30 – Key Strategies for Optimizing Cognitive Function 00:22:00 – The Marama Experience: Memory Care to Memory Recovery 00:30:00 – Steps for Protecting Brain Health Over Time See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Sep 20241h 2min

The Cognitive Power of AmaTea® Max for Sustainable Energy & Mental Clarity : 1198

The Cognitive Power of AmaTea® Max for Sustainable Energy & Mental Clarity : 1198

In this episode of The Human Upgrade, Dave Asprey talks to Chris Fields, Chief Science Officer at Applied Food Sciences, about the game-changing nootropic AmaTea® Max. They discuss how this natural extract of guayusa delivers long-lasting energy and mental clarity, backed by science and sustainable practices. Learn how AmaTea® Max is revolutionizing cognitive performance, especially for athletes and gamers. Resources: Where to buy products with AmaTea® organic guayusa: https://appliedfoods.com/wheretobuyAmaTea® Max Website: https://appliedfoods.com/amateamax AmaTea® Max Instagram: https://www.instagram.com/appliedfoodsciences Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ Timestamps and Highlights: 00:01 – Why Caffeine is a Super-Powerful Nootropic 04:00 – The Science of Guayusa and AmaTea® Max 07:00 – Cultural Roots and Sustainable Sourcing 11:30 – The Cognitive Benefits of AmaTea® Max 16:20 – How AmaTea® Max Differs from Traditional Caffeine Sources 20:00 – Applications in Gaming and Sports 25:00 – Sustainability and Social Impact See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Sep 202441min

Rewiring Your Brain for Hope: How to Overcome Cynicism with Dr. Jamil Zaki : 1197

Rewiring Your Brain for Hope: How to Overcome Cynicism with Dr. Jamil Zaki : 1197

In this episode of The Human Upgrade, Dave Asprey welcomes Dr. Jamil Zaki, a professor of psychology at Stanford University and the director of the Stanford Social Neuroscience Lab. Dr. Zaki discusses the critical intersection between empathy, cynicism, and hope, exploring the impacts of negativity bias, cynicism in modern society, and how we can rewire our brains to become more hopeful. Drawing from his latest research and new book, Hope for Cynics, Dr. Zaki shares profound insights on human goodness, how we can challenge our biases, and the practices that can help us foster a more positive outlook on the world. Sponsors: Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: Jamil Zaki’s website: jamil-zaki.com Jamil Zaki's New Book: Hope for Cynics: The Surprising Science of Human Goodness Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ Timestamps and Highlights: 00:00:01 – Introduction by Dave Asprey 00:02:00 – Dr. Zaki on Cynicism and Empathy 00:05:30 – The Science Behind Empathy and Human Goodness 00:10:00 – The Impact of Negativity Bias on Decision-Making 00:15:00 – How to Overcome Cynicism Through Skepticism 00:20:30 – Practices to Foster Empathy and Optimism 00:30:00 – Understanding Cynicism in the Digital Age 00:35:00 – Building Hope in Relationships and Society See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Sep 20241h 2min

Making Billions: Lessons Learned From the King of the Thrill Pill Cult – Shaahin Cheyene

Making Billions: Lessons Learned From the King of the Thrill Pill Cult – Shaahin Cheyene

In this special Asprey Archive episode from 2023, we talk to Shaahin Cheyene.Today’s guest is nothing short of a modern-day Willy Wonka for Generation X. He built a billion-dollar ecstasy business in the '90s and did not end up behind bars. That's a story you've got to hear. Shaahin Cheyene, not only dabbled in the wild world of herbal ecstasy but also managed to stay out of trouble despite being investigated by seven attorney generals. And get this, he wasn't even 18 when he pulled off these daring feats.Shaahin's story doesn't stop there. Since those days, he's become an Amazon expert, successfully selling nootropics and a variety of other products on the platform. He's also a filmmaker and author of the book, “Billion: How I Became the King of the Thrill Pill Cult.” From Fleeing Iran at the age of five to being homeless and living out of his car, Shaahin's journey is nothing short of remarkable. It's safe to say he's one of the most interesting individuals I've had the pleasure of interviewing. We dive into Shaahin's captivating journey, exploring his transformation from a young criminal to a thriving entrepreneur. You’ll also learn about what went into his groundbreaking herbal ecstasy formula and how he managed to get his business off the ground. Along the way, we discuss the challenges of navigating the bureaucracy of big government, the importance of seeking help when needed, and the valuable lessons Shaahin learned from building and eventually exiting his herbal ecstasy empire. We also delve into how he managed to run a nine-figure company selling on Amazon, the mindset benefits of Brazilian jiu-jitsu training, the power of curating ideas, and how you can strategically leverage podcasts as an entrepreneur. Join us on a ride you won't want to miss.(01:47) How Shaahin Became the King of the Thrill Pill Cult(07:36) Formulating Herbal Ecstasy & Building a Million-Dollar Business(16:34) Navigating the Bureaucracy of Big Government(28:04) Pro Tip for Entrepreneurs: Why It’s Important To Ask for Help(32:09) What Cheyene Learned From Building & Exiting His Business(37:29) What To Do When You Make Your First Million(39:21) Scaling a 9-Figure Company Selling on Amazon(45:05) Lessons From Martial Arts & Our Bets on Musk vs Zuckerberg(54:03) The Tactical Advantage of Podcasting & Being a Curator of Ideas(01:03:30) Media Training 101SponsorsLMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave.Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. ResourcesWebsite: shaahincheyenne.comPodcastCola: podcastcola.comInstagram: @shaahincheyenePodcast: Business Story of the WeekLinkedIn: Shaahin CheyeneSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Sep 20241h 9min

Experts on How to Improve Your Vision Naturally : 1196

Experts on How to Improve Your Vision Naturally : 1196

In this episode of The Human Upgrade, vision expert Claudia Muehlenweg and strength coach Dave Mark Bell join Dave Asprey to explore the intersection of natural vision improvement and physical performance. Claudia shares her expertise in the Bates Method and techniques like palming, which help restore clarity and reduce eye strain. Dave Mark Bell highlights how physical training and focus can enhance not only strength but also vision, showing the deep connection between the body and mind. Check out the Full Episodes here: Claudia Muehlenweg: https://youtu.be/SpO6k9Ofh2EDave Mark Bell: https://youtu.be/GV2KnL0wW9MSponsors: Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: Naturally Clear Vision | Claudia Muehlenweg: https://www.youtube.com/@HolisticVisionCoach Dave Mark Bell’s Instagram: @marksmellybell Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ Timestamps and Highlights: 00:00:01 — Introduction by Dave Asprey 00:01:02 — Claudia Muehlenweg’s Introduction 00:03:30 — Palming and Its Benefits 00:06:15 — The Role of Eye Movement in Vision Health 00:09:25 — Dave Mark Bell’s Approach to Physical Training and Vision 00:12:45 — Sunlight and Vision 00:18:35 — Vision Improvement Techniques for Daily Life 00:22:50 — Vision and Fitness Synergy with Dave Mark Bell See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Aug 20241h 8min

Exploring Polymathy, Biohacking, and Consciousness with Robert Edward Grant : 1195

Exploring Polymathy, Biohacking, and Consciousness with Robert Edward Grant : 1195

In this enlightening episode of The Human Upgrade, Dave Asprey is joined by polymath and visionary Robert Edward Grant. Known for his groundbreaking work in fields ranging from mathematics and cryptography to art and consciousness, Robert shares insights into how his diverse expertise has shaped his understanding of the interconnectedness of science, art, and spirituality. The conversation delves into ancient knowledge, biohacking for personal evolution, and the deeper mysteries of consciousness, exploring how tapping into these realms can lead to profound innovation and a higher state of being. Sponsors: OneSkin | Go to https://oneskin.co/ and use code ASPREY15 for 15% off your purchase. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: Robert Grant’s Website: robertedwardgrant.com Follow Robert Grant on Instagram: @robertedwardgrant Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ Timestamps and Highlights: 00:00:01 — Introduction by Dave Asprey 00:02:05 — What It Means to Be a Polymath 00:05:34 — Innovation Through Cross-Disciplinary Thinking 00:08:26 — Consciousness and Psychedelics 00:13:22 — The Limits of Knowledge and Enlightenment 00:28:35 — The Path to Enlightenment 00:30:29 — The Benefits of Fasting for Mental and Physical Clarity 00:34:52 — The Power of Cold Therapy 00:38:23 — Overcoming Challenges in Biohacking See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Aug 20241h 16min

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