BBC Inside Science

BBC Inside Science

A weekly programme that illuminates the mysteries and challenges the controversies behind the science that's changing our world.

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Personal genetics kits; Persister cells; Earthquake mapping; Scorpions

Personal genetics kits; Persister cells; Earthquake mapping; Scorpions

For a couple of hundred quid, one of many companies will send you a kit for sampling your own genome, and most will tell you your genetic risk for some diseases. In December the US Food and Drug Administration imposed a ban on one of these companies, 23andme. The reasoning was that if the organisation is offering medical advice, it needs to be medically regulated. Geneticist Professor Robert Green from Harvard Medical School argues that people can cope responsibly with their genetic information and that the FDA is being over-cautious.Most people are familiar with recurrent infections caused by bacteria such as tonsillitis and bladder infections, where you pick up an infection, get treated with antibiotics and then after a few weeks or months the infection reappears and you need another course of antibiotics; this is a problem that can go on for many years, and is a major healthcare burden world-wide. Marnie Chesterton met a team from Imperial College studying the elusive persister cells responsible for these relapses.Earthquakes usually occur in subduction zones, where one tectonic plate plunges beneath another. Now a team at University of Aberdeen has analysed a large earthquake database and developed a global map giving clues to which areas could be capable of causing giant earthquakes. Professor Nicholas Rawlinson explains the difficulties of predicting.The venom of scorpions contains neurotoxins, which attack the nervous system of animals - it's one of the reasons why it's not a good idea to be stung by a scorpion. The structure of these toxins very closely resembles the structure of a group of proteins with a completely different purpose, called defensins. Professor Jan Tytgat from KU Leauven suggests that venom evolved from these defensins.

16 Jan 201428min

Antarctica weather and climate change; GM Fish Oils; Melanin Fossils; Time Travel

Antarctica weather and climate change; GM Fish Oils; Melanin Fossils; Time Travel

Scientists following in the footsteps of Edwardian explorer, Douglas Mawson, have been trapped in pack ice in the Antarctic. The Chinese vessel that came to their rescue also became "beset" in the ice. The BBC's Andrew Luck Baker talks to Adam Rutherford about the catacylsmic event that caused multi-year ice to break away and trap the Academik Shokalskiy and Professor John Turner of the British Antarctic Survey underlines the importance of differentiating between extreme weather events and the impact of climate change.A team at Rothamsted Research in Hertfordshire has succeeded in genetically engineering plant seeds to contain the Omega-3 oil usually found in oily fish. Seeds from Camelina sativa (false flax) plants were modified using genes from microalgae - the primary organisms that produce these beneficial fatty acids.The oil has now been incorporated into salmon feed to assess whether it's a viable alternative to wild fish oil. Dr Johnathan Napier tells Melissa Hogenboom that he hopes the plants will provide a sustainable source of long chain polyunsaturated fatty acids.From fossils we know an awful lot about the animals that walked on the Earth, swam in the sea and flew in the air. But fossils have never been good at revealing the colour of these animals. With increasingly sophisticated sampling techniques however, scientists are starting to get a much better, technicolour glimpse into these extinct fauna. And it turns out that colour played a much more important role than just camouflage and decoration. Johan Lindgren form Lund University in Sweden has been finding out how the pigment, melanin, allowed ancient marine reptiles to travel all over the oceanic globe.Show Us Your Instrument: Dr Andrew Polaszek, Head of Terrestrial Invertebrates at the Natural History Museum reveals his compound microscope (with Nomarski Differential Interference Contrast) which he uses to discover "hidden biodiversity", particularly in parasitoid wasps.Stephen Hawking threw a party for time travellers and issued the invitation after the event. Astrophysicists after a long poker game decided to use Twitter instead, to flush out the time travellers in our midst. Professor Robert Nemiroff from Michigan Tech University and his students mined social media for references to the Comet ISON and the naming of the new Pope Francis, before both those events had actually happened. Producer: Fiona Hill.

9 Jan 201427min

Ancient Human Occupation of Britain

Ancient Human Occupation of Britain

The ancient inhabitants of Britain; when did they get here? Who were they? And how do we know? Alice Roberts meets some of the AHOB team, who have been literally digging for answers.The Natural History Museum's Chris Stringer, is the Director of AHOB, the Ancient Human Occupation of Britain, a project which, over the past 12 years, has brought together a large team of palaeontologists, archaeologists, geologists and geographers, to pool their expertise in order to unpick British History.Nick Ashton from the British Museum has been in charge of the north Norfolk site of Happisburgh, where the crumbling coast line has revealed the oldest examples of human life in Britain, 400,000 years earlier than previous findings of human habitation, in Boxgrove in Sussex.The ancient landscape had its share of exotic animals. Hippos have been dug up from Trafalgar Square, mammoths have been excavated from Fleet Street. Professor Danielle Schreve is an expert in ancient mammal fossils, and tells us what these bones reveal about the ancient climate. Less glamorous than the big fossils, the humble vole is so useful and accurate as a dating tool that it has been nicknamed "the Vole Clock."Carbon dating has improved vastly in the past few years. Rob Dinnis, from Edinburgh University, explains why the AHOB team has been returning to old collections and redating them.

6 Jan 201427min

Bacteriophages; Breath-detecting disease; Our bees electric and DNA Barcoding

Bacteriophages; Breath-detecting disease; Our bees electric and DNA Barcoding

Professor Alice Roberts talks bacteriophages: viruses that infect the bacteria that infect us. With the rise of antibiotic resistance they are a potential weapon against infection.We hear from Paul Hebert, the biologist behind the International Barcode of Life project – a global effort to classify the entire world’s species according to their DNA. Bristol researchers have discovered that it is more than scent and colour that draws a bee to a flower – there is also an electric field.Claire Turner from the Open University shows us the instrument she uses to detect disease. It can sense when a heart transplant patient is rejecting their new organ, purely through monitoring their breath.

26 Dec 201327min

Antimicrobial soap; GAIA; Stone-age jellybones; Antarctica

Antimicrobial soap; GAIA; Stone-age jellybones; Antarctica

Antibacterial soaps and body washes make up an industry worth millions of pounds, but in the USA, producers have been told that they have just over a year to prove their products are safe, or, re-label or reformulate them. Many believe that using antimicrobial soaps, which often include the chemicals triclosan or triclocarban, keeps you clean and reduces the chance of getting ill or passing on germs to others. But the Food and Drug Administration in the USA says it's the job of manufacturers to demonstrate the benefits, to balance any potential risks. Professor Jodi Lindsay, expert in microbial pathogenesis from St Georges, University of London, tells Dr Adam Rutherford where this leaves British and European consumers.The world's most powerful satellite camera was launched today into space. Its mission, to map the billion stars in our galaxy. Professor Gerry Gilmore, Principal Investigator for GAIA, tells Inside Science about the planned "walk through the Milky Way" and BBC Science Correspondent, Jonathan Amos, spells out how GAIA could help detect future asteroids, like the one that wiped out the dinosaurs on earth.Just after the Second World War in a site in North Yorkshire, the discovery of a flint blade triggered the discovery of one of the world's most important Mesolithic or Stone Age sites. What makes Star Carr so special is that organic artefacts, bone harpoons, deer headdresses and even homesteads, were preserved in the peat 11000 years ago. But these precious artefacts are in trouble. Changing acidic conditions are turning the Mesolithic remains to jelly. Sue Nelson reports from the Vale of Pickering on how archaeologists are working with chemists to try to pinpoint exactly why the Stone Age remains are deteriorating so quickly.And Professor Chris Turney talks to Adam from his research ship in Commonwealth Bay in the Antarctic, where he is leading a team of scientists to recreate the journey made by Douglas Mawson, 100 years ago, on the Australasian Antarctic Expedition.Producer: Fiona Hill.

19 Dec 201328min

Horsemeat; NanoSims; Early bacteria; Crystallography

Horsemeat; NanoSims; Early bacteria; Crystallography

Food crime is now big business that criss crosses national boundaries, according to today's report into the safety and authenticity of our food. Public Analyst, Dr Duncan Campbell tells Dr Adam Rutherford that he and his colleagues are hampered by lack of funding and the lack of a national plan for a sustainable laboratory infrastructure. While report author, Professor Chris Elliott, the director of the Global Institute for Food Security at Queen's University, Belfast describes how he wants the UK's scientific infrastructure to be strengthened to avoid yet another serious food scandal.Show Us Your Instrument: Cosmic Scientist Dr Natalie Starkey from the School of Planetary and Space Sciences at the Open University reveals the NanoSims instrument.Thousands of miles apart the same species of microbes seem to crop up deep beneath the earth's surface in cracks of hard rock. Yet nobody seems to quite know how they spread so widely. Scientists now believe they may have survived completely isolated from the surface for what could be billions of years. Dr Matt Shrenk from Michigan State University explains that the biosphere as we know it is far more extensive than we previously thought.Crystallography... as it sounds is the study of crystals, but it's not quite as simple as that. It underpins many scientific fields and yet it remains a relatively unknown subject area. Scores of Nobel prizes have been won, the first almost 100 years ago and we wouldn't understand the structure of DNA without it. The United Nations has declared 2014 as the International Year of Crystallography and emeritus Professor Mike Glazer from Oxford University says he hopes it will help bring the subject out of the shadows.Producer: Fiona Hill.

12 Dec 201327min

Badger culls; Douglas Mawson; Plastics; Uptalk

Badger culls; Douglas Mawson; Plastics; Uptalk

Badger culls in England have ended and Professor Roland Kao from the University of Glasgow discusses with Dr Adam Rutherford the scientific options remaining to tackle the spread of bovine tuberculosis. Field trials of the TB cattle vaccine are due to start next year and Professor Kao hopes that their success in sequencing the genome of Mycobactrium bovis will also provide a greater understanding about how this devastating disease spreads. The name of Douglas Mawson isn't discussed along with the famous triumvirate, Scott, Amundsen and Shackleton, but one hundred years ago, he led the first science-only Australasian Antarctic Expedition. A century later, Professor Chris Turney is co-leading a repeat expedition, where scientists will repeat many of the measurements of the Mawson trip.Rising inflexion at the end of your sentences is known as "uptalk" or "valleygirl speak" and it's usually associated with young Californian females. But now a new study shows that uptalk is expanding to men. Professor Amalia Arvaniti explains that uptalk has negative connotations which makes men less likely to admit to using it, but it was clear was that this pattern of speech is like totally spreading.Waste plastic makes its way into many areas of the environment which can threaten wildlife. Small particles of plastic can also be ingested by organisms and as they act almost like sponges the plastics attract other chemicals onto their surface. Despite this their hazard ranking is the same as scraps of food or grass clippings. Dr Mark Browne from the National Centre for Ecological Analysis and Synthesis, USA, describes his new research in the journal, Current Biology, which shows that these microplastics have toxic concentrations of pollutants in which can harm biodiversity. He also explains how these microplastics transfer toxic pollutants and chemicals into the guts of lugworms. These worms have been nicknamed "eco-engineers" because they eat organic matter from the sediment and prevent the build-up of silt.Producer: Fiona Hill.

5 Dec 201327min

Therapeutic hypothermia; Cameras on Gaia; Methane; Wine microbiota

Therapeutic hypothermia; Cameras on Gaia; Methane; Wine microbiota

Therapeutic hypothermia is standard treatment for cardiac arrest patients to protect against the damaging or deadly repercussions of a beatless heart. But this global practice has been called into question after research in the New England Journal of Medicine reported no difference in survival rates between patients chilled to 33 degrees and those cooled to just below normal body temperature to 36 degrees. Dr Jerry Nolan, vice chair of the European Resuscitation Council tells Dr Adam Rutherford how doctors worldwide are reacting to this new study and Dr Kevin Fong, author of "Extremes, Life, Death and the Limits of the Human Body" describes how medicine has historically harnessed hypothermic states to heal.Show Us Your Instrument: The European Space Agency's GAIA mission is due to launch just before Christmas. It will spend the next 5 years recording space, using a billion pixel camera. This camera is made up of charge-couple devices, similar to the ones you'd find in your smart phone. These are damaged by space radiation. Dr Ross Burgon damages them in his lab first, to tell whether the images coming back from space are real stars or planets, or the digital equivalent of a smudge on the lens.Methane is the second most important greenhouse gas after carbon dioxide because it's 25 times more powerful than carbon dioxide at trapping the sun's rays. And it doesn't hang around as long either, ten years as opposed to a 100. So tackling methane is seen by many countries as a useful way of reducing greenhouse gases, quickly. But that depends on knowing how much there is. A new paper in the Proceedings of the National Academy of Sciences reveals that United States could be underestimating its methane emissions by as much as fifty per cent. Dr Vincent Gauci Head of Ecosystems and Biodiversity at the Open University explains how the Americans got their sums so wrong, and considers whether the British calculations are similarly suspect.The fuzzy concept of "terroir" for wine fans has always been difficult to pin down. Climate, soil, geology and individual wine-making practice don't make it easy to identify what makes particular wines unique. But Dr David Mills, Professor in the Department of Viticulture and Enology at University of California, Davis, has used DNA sequencing to study the microbial ecology of individual grapes. And he concludes bacteria and fungi could explain "microbial terroir".Producer: Fiona Hill.

28 Nov 201327min

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