135: Micronutrients and Modern Human Evolution
Rees J et al., The American Journal of Human Genetics - Rees et al. analyze signatures of positive selection in 276 genes linked to 13 dietary micronutrients across 40 global populations (HGDP). Using...
12 Sep 202514min
134: Single-cell view of Barrett's esophagus and EAC
Wenzel M et al., Cell Genomics - This episode reviews a single-cell transcriptional atlas comparing Barrett's esophagus, intestinal metaplasia, normal esophagus/gastric samples and esophageal adenocar...
11 Sep 202515min
133: Long-read meta-pangenomics links gut genomes to child growth
Minich JJ et al., Cell - Minich et al. apply PacBio and Oxford Nanopore long‑read metagenomics to generate 986 complete metagenome‑assembled genomes from Malawian toddler fecal samples, then use pange...
10 Sep 202524min
132: Transcriptome classifiers predict docetaxel sensitivity in advanced prostate cancer
Grist E et al., Cell - Large-scale transcriptome profiling of 1,523 diagnostic prostate tumors from randomized STAMPEDE phase 3 trials linked expression signatures and immunohistochemistry to 14-year ...
9 Sep 202520min
131: Cryptic plasmid pBI143: a small element with outsized presence in the human gut
Fogarty EC et al., Cell (187:1206–1222, February 29, 2024) - This episode summarizes Fogarty et al. 2024, which characterizes pBI143, a 2.7 kb cryptic plasmid that is highly prevalent and abundant acr...
8 Sep 202517min
130: Genetics + CRISPR to Map Obesity and Fat Distribution
Baya NA et al., The American Journal of Human Genetics - This episode summarizes a multi-modal study that integrates exome sequencing in 402,375 UK Biobank participants with CRISPR knockdown in human ...
7 Sep 202520min
129: NPIP — Structural variation, selection, and paralog diversification
Dishuck PC et al., Cell Genomics - Using 169 long-read human haplotypes and 1.4 billion full-length cDNA reads, Dishuck et al. resolve the complex NPIP gene family on chromosome 16, revealing extreme ...
6 Sep 202522min
128: L1 elements, chromatin and CRISPRi
Adami A et al., Cell Genomics - This episode covers analyses of L1 retrotransposon subfamilies (L1PA2/3/4, L1HS), their chromatin signatures (including H3K4me3), and perturbation experiments using CRI...
5 Sep 202515min
