What is consulting life like? (Ep. 43)
In this episode I discuss my experience as an independent consultant in the clinical pharmacology and pharmacometrics space. I talk about how I got from high school to become a consultant. I touched o...
24 Mars 202530min
Population PK modeling with nlmixr (Ep. 42)
In this episode I discuss using nlmixr for population PK modeling in R. I give an overview of the software package, describe the installation process, and walk through a simple example. Overall, nlmix...
24 Feb 202525min
Sample size calculations (Ep. 41)
In this episode I discuss power calculations using the R package PowerTOST. I gave an introduction to power calculations and the statistical premise. I reviewed bioequivalence study designs that are c...
31 Jan 202534min
Collaboration with BioTalk Unzipped (Ep. 40)
In this episode I share a couple short clips from my conversation with Chad Briscoe and Greg Austin from BioTalk Unzipped (www.biotalkunzipped.com). We chat about a variety of topics including artific...
30 Dec 202413min
Toxicokinetics (Ep. 39)
In this episode I discuss toxicokinetic analysis. This is the analysis of exposure data to support animal toxicology studies. I review the purpose of toxicology studies and how exposure metrics are us...
9 Dec 202419min
Steady State (Ep. 38)
This episode is a discussion of steady state pharmacokinetics. Steady state occurs when the amount of drug input is equivalent to the amount of drug elimination in a dosing interval. I discuss some ke...
25 Nov 202416min
Dose Proportionality (Ep. 37)
In this episode I talk about dose proportionality, which is a surrogate for determining if we have linear clearance across a range of dose levels. I discuss 3 different methods that people use to dete...
11 Nov 202416min
Covariate Search Methods (Ep. 36)
This episode is a discussion of covariate search methods. I give definitions of covariates and predictors, and then I describe 3 different covariate search methods. For each method I describe the pros...
28 Okt 202427min
