Effect compartment PK-PD models (Ep. 33)
In this episode I describe effect compartment PK-PD models. I describe how they work, a method of creating exploratory plots, how to set up the dataset for NONMEM, and how to code the model in NONMEM....
9 Sep 202429min
Direct effect PKPD models (Ep. 32)
In this episode I describe direct effect PK-PD models. I describe how they work, a method of creating exploratory plots to identify direct effect models, how to set up the dataset for NONMEM, and how ...
26 Aug 202431min
What should you use to present PK results? (Ep. 31)
In this episode I discuss different methods of presenting pharmacokinetic and pharmacometrics results. I spoke about using PowerPoint and R Markdown derived HTML files. While I prefer HTML files in ne...
12 Aug 202431min
How important is terminal rate constant? (Ep. 30)
This episode covers the terminal elimination rate constant calculated using non-compartmental analysis techniques. I reviewed how the rate constant is used to estimate half-life and extrapolate AUC to...
22 Juli 202426min
Parellelization in modeling (Ep. 29)
This episode covered parallelization in modeling analyses. I spoke about across model parallelization and within model parallelization. I recommended some approaches for choosing how many cores to use...
8 Juli 202418min
Residual errors and submission packages (Ep. 28)
Today I covered 2 different topics. First, I spoke about residual error models when modeling. I discussed additive, proportional, and power models. I also reviewed combined models and when they can be...
24 Juni 202427min
Simulations (Ep. 27)
This episode discusses simulations. I group simulations into 4 categories: (1) average response, (2) population, (3) individual, and (4) clinical trial simulations. I discuss details of each of these ...
10 Juni 202420min
Different work environments (Ep. 26)
Today’s show is about different work environments and not scientific topics. Throughout my career I have worked in many different types of companies, and I would like to share some observations with y...
27 Maj 202435min
