The Human Upgrade: Biohacking for Longevity & Performance

Today’s guest is not a scientist but a true visionary. Gary Vaynerchuk (aka Gary Vee), is a self-made entrepreneur and digital marketing pioneer. He started his business journey with a lemonade stand at age seven. Now, he’s a prolific content creator, best-selling author, and the co-founder of the massive digital agency VaynerMedia. What I love about Gary is that he leads with integrity, optimism, and, above all, gratitude. He’s a guy of wisdom, not just business—and that’s an important element of what The Human Upgrade is all about.In today’s episode, we explore how entrepreneurship has changed since Gary and I started. We get into how to grow a business in 2024 and Gary’s advice for anyone starting out. His secret to success will surprise you. We talk a lot about gratitude, and how that lens has shaped Gary’s long career and kept him from burning out. Gary also shares his perspective on today’s social media landscape, the importance of kind candor, and why we should look to our elders. No doubt, listening to Gary will inspire you to go after your passions and try that thing you’ve been putting off. In Gary’s words, your happiness is worth fighting for!(00:02:01) Redefining Success as an Entrepreneur(00:07:02) How Gary’s Upbringing Impacted His Success(00:10:32) The Truth About Social Media in 2024(00:14:49) Is Everyone Just Copying Each Other?(00:18:50) Gratitude As the Antidote for Burnout(00:24:11) Championing Wisdom Instead of Youth(00:29:21) Prioritizing Joy Over Riches(00:38:02) Recognizing the Importance of Kind Candor(00:43:08) Reframing Relationships & the Perspectives You Engage With(00:47:17) Leading With Gratitude, Not FearSponsor40 Years of Zen | Go to 40yearsofzen.com/dave to receive an exclusive offer for podcast listeners. ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: garyvaynerchuk.comInstagram: @garyveeTikTok: @garyveeFacebook: Gary Vaynerchuk YouTube: @garyveeX: @garyveeDiscord: VeeFriends The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Jan 202458min

I'm excited to welcome back Dr. Steven Gundry to The Human Upgrade for his sixth appearance, a tribute to his remarkable insights and ongoing research.Dr. Gundry, a true pioneer, is renowned for his books like "The Plant Paradox" and his groundbreaking work on lectins, changing how we understand our body's reaction to food. He's also a top cardiothoracic surgeon and a leader in robotic cardiac surgery, with over two decades of research into the microbiome, using diet and nutrition as key treatment tools. His book, "Unlocking the Keto Code," and his wellness line, GundryMD, have made significant impacts in health and nutrition.In this episode, we dive into cutting-edge research from his new book “Gut Check.” Dr. Gundry discusses the microbiome's connection to disease, and gut health's role in hormone regulation, crucial for mental health during menopause. He'll also share insights on dietary choices, the truth about parasites, and nicotine's unexpected role in longevity.Dr. Gundry's transformative wisdom bridges traditional and alternative medicine. A big thank you to him for another enlightening visit. Thanks for joining us on this journey of discovery!(00:00:22) The Latest Research on How To Reverse Disease(00:10:16) The Link Between Leaky Gut & Gluten(00:16:50) Debunking Blue Zones(00:19:28) What Meat Products You Should Eat & Avoid(00:23:43) The Latest Data on New 5GC, 5AC & Fermented Meat(00:34:27) The Real Issue with Oxalates & How To Boost Your Defenses(00:41:33) How the Microbiome Influences Hormones & Menopause(00:48:10) What Foods Have the Highest Risk for Parasites According to Dr. Gundry(00:55:11) Benefits & Risks of Berberine(00:58:21) The Surprising Truth About Nicotine & Longevity(01:09:11) The Downside to Too Much Olive OilSponsorsARMRA | Visit tryarmra.com and use the code DAVE to get 15% off your first order.Leela Q | Visit leelaq.com/dave and get a 10% discount on LeelaQ products. ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Read: Gut Check by Dr. Steven GundryWebsite: drgundry.comPodcast: The Dr. Gundry PodcastKeto Gets an Upgrade – Dr. Steven Gundry #912How to Identify Your Energy Blockers and Beat Fatigue – Dr. Steven Gundry with Dave Asprey – #803 How Foods are Harming Your Kids – Steven Gundry, M.D. – #649Healthy Aging Begins and Ends in the Gut – Dr. Steven Gundry #604How Nutrition Can Reverse Disease and the Impact of Lectins – Dr. Steven Gundry – #417The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Jan 20241h 15min

On today’s Upgrade Spotlight episode, we’re talking all about NAD+. In the biohacking world, everyone and their mother has heard of NMN and NAD+, but there’s more to it than meets the eye. To get into the nitty gritty of NAD+, we’re joined by Dr. Gregory Kelly, a naturopathic physician and the lead product formulator at Neurohacker Collective, also known as Qualia. I’m an advisor to the company, and they do fantastic and innovative work in the longevity space. Their NAD+ supplement is a quantum leap in biohacking and a no-brainer to add to your stack. In today’s episode, Dr. Kelly explains what NAD is and why it’s essential for longevity, cognition, energy levels, and athletic performance. We talk about the differences between NR, NMN, and Niacinamide. We also explore the most efficient way to get NAD. Is an IV worth the money or will supplements give you more bang for your buck? Plus, Dr. Kelly breaks down exactly what’s included—and not included—in the Qualia NAD+ formula. I’ve been a major proponent of NAD for more than 10 years, but I don’t like to spend all my time and money getting it. If you feel the same, you’re going to want to tune into this episode. (00:01:55) What Is NAD & Why Do We Care?(00:06:19) The Most Efficient Way To Get NAD(00:09:55) Sirtuin’s Superpowers (00:14:42) The Qualia NAD+ Formula (00:22:37) The Buzz on Coffee Berry (00:25:53) When Is the Best Time To Take NAD+? (00:30:01) NAD+ in Clinical Trials (00:34:16) What’s NOT in the Qualia Supplement (00:38:02) A Quantum Leap for Biohacking Episode SponsorNeurohacker | Boost YOUR NAD+ up to 50%* + GET 50% OFF go to neurohacker.com/DAVENAD.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Visit neurohacker.com/davenad to save 50% on Qualia NAD+ by Neurohacker Neurohacker Collective: neurohacker.comNeurohacker Collective Instagram: @neurohacker Linkedin: Gregory Kelly The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Jan 202441min

Today, we take a look into the mindset and habits of successful entrepreneurs and mastering the art of organization for success, topics that today’s guest has totally mastered. Jesse Itzler has an impressive background with a bachelor's degree from American University and a further degree in justice, law, and society. His resume as an entrepreneur is also quite impressive, co-founding Marquis Jet, the world's largest private jet card company, which was later sold to Berkshire Hathaway/NetJets. Beyond this, he's partnered with Zico coconut water, selling it to The Coca-Cola Company, and has ventured into the music industry, co-writing Billboard Top 100 hits and co-founding Alphabet City Sports Records. Jesse is also an acclaimed triathlete and author, with his book, Living with a Seal, becoming a New York Times bestseller.As we step into the early days of 2024, this episode is all about providing you with clear, direct methods to upgrade your life across various facets—work, fitness, and personal development. Tune in as I compare and contrast my organizational methods with Jesse's, the goal being to introduce you to strategies that resonate with you and align with your personality. You'll gain insights into how Jesse efficiently prioritizes his calendar and the skills needed to outperform competition when you’re starting out in business. We also explore habits and tools for staying physically and mentally young, our favorite biohacks, my personal excitement in the field of longevity, and ways to structure your life for maximum return on investment, both in terms of monetary success and happiness. While our methods differ in some areas, our objective is the same: to live a life with minimal regrets, whether you reach 80 or 180 years old. Join us as we discuss the habits of successful entrepreneurs—both from our experience and learning from others at the top of their game—and discover practical ways to implement these lessons into your life.(00:00:20) The Secret to Jesse’s Success in Business & Triathlons(00:05:10) How Jesse Organizes His Life & Implements New Habits(00:22:49) Structuring Support Systems & Early Hires(00:32:41) Lessons From Living With a Seal & Monks(00:48:19) What Biohacks Dave Is Most Excited About(00:54:21) How To Organize Your Time Efficiently(01:01:54) The Mindset & Habits of Successful Entrepreneurs(01:10:34) The Recipe for a Fulfilling Life(01:18:46) Dave’s Top Tools for LongevitySponsor: https://www.viome.com/dave to save $150 full body intelligence test.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: jesseitzler.comInstagram: @jesseitzlerTikTok: @jesseitzlerYouTube: Jesse ItzlerLinkedin: Jesse ItzlerThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Jan 20241h 25min

Dr. Anthony Youn, aka “America’s Holistic Plastic Surgeon,” is an expert in your face. He joins us to answer some burning questions… Can plastic surgery actually be holistic? Can you turn back the clock without going under the knife? And… What work should I get done to my face? Today, we’re talking all about how to hack your face and save your skin. Dr. Youn is a nationally-recognized, board-certified plastic surgeon. He’s the most followed plastic surgeon on social media and a TikTok star. He’s the author of The Age Fix, In Stitches, and Playing God. His new book, Younger For Life, is a complete holistic guide to anti-aging using a process he coined called Autojuvenation. In today’s episode, we get into what Autojuvenation is, and how it helps you look younger without surgery—a surgeon who wants to help you avoid surgery! We talk about blending biohacking and cosmetics, natural vs. medical-grade skincare, collagen peptides, treating hair loss, and whether sunscreen causes or prevents cancer. Dr. Youn also tells us the dumbest things that both men and women do to their faces—and how to avoid them. Let’s face it, many of us want to look younger. This conversation is a fascinating look at how to approach aesthetics from a biohacker’s perspective. (00:01:55) Is There Such Thing As Holistic Plastic Surgery?(00:05:12) Natural vs. Medical-Grade Skincare(00:09:36) Holistic Alternatives That Traditional Physicians Don’t Know(00:16:47) Does Topical Collagen Work?(00:19:45) What Cosmetic Work Should Dave Have Done?(00:25:20) Blending Biohacking & Cosmetics(00:30:38) The Dumbest Things Men Do to Their Skin(00:35:37) Is Sunscreen Preventing or Causing Cancer?(00:38:33) The Dumbest Things Women Do to Their Skin(00:43:54) The Hair-Raising Effects of Hair Loss(00:52:35) Additional Skin Biohacks from a ProSponsors:Tru Kava https://trukava.com/ use code Dave15One Skin: https://www.oneskin.co/ use code Upgrade15ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: dryoun.comPre-order: Younger For Life (over $100 value of free bonuses)TikTok: @doctoryoun Instagram: @tonyyounmdYouTube: @DoctorYounPodcast: The Holistic Plastic Surgery Show The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Jan 20241h

Get ready for this important download on a fascinating biohacking compound you haven’t heard me talk about before: Urolithin A. It’s a postbiotic that supports the mitochondria, and it’s backed by impressive studies on longevity, anti-cancer effects, cognitive function, and muscle strength. In fact, this compound has earned a place in my permanent stack—which you know isn’t easy to pull off.Today, I chat with Dr. Dominic Denk, who’s done some of the original research on Urolithin A and the company that makes it, Timeline Nutrition powered by Mitopure. Dr. Denk works as a physician in the Department of Internal Medicine at University Hospital Frankfurt. Dr. Denk breaks down what Urolithin A is and how it impacts aging and cancer prevention—answering questions on when, how, and why to take Mitopure—before we delve into the powers of mitochondria, how to have more energy production in your cells, and the relationship between energy production and cancer. We also talk T cells, autoimmunity, and inflammation. Plus, we get into the differences in healthcare and pharmaceutical overreach in the U.S. and Germany. Tune in to uncover the latest life-changing compound—and find out what it will do for your heaviest lift in the gym, your cognition before your next big meeting, and to reverse aging over time. (00:03:31) Understanding Urolithin A (00:08:43) Genetic vs. Mitochondrial Cancer (00:14:48) Getting to the Root of Autoimmunity (00:21:19) Strong Evidence on Muscle Strength (00:23:59) Does Cancer Hate Americans? (00:27:59) Why Do We Age? (00:31:35) The Best Studied Compound You’re Not Taking (00:33:02) Talking T Cells (00:36:22) Healthcare in Germany vs. The U.S. (00:43:31) Urolithin A & Hot/Cold Therapies (00:45:55) Tripling Down on mTOR (00:52:05) Are There Downsides to Urolithin A? ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Timeline Nutrition: timelinenutrition.com and use code DAVE to save 10%. After January 1st, 2024, TimelineNutrition.com/dave for 30% discount.Mitopure: mitopure.comX: @DomDenkMDLinkedin: Dr.med. Dominic Denk The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Dec 202358min

In this special end-of-year "best of" episode, you'll learn the Top 10 hallmarks of aging, the role of functional medicine in restoring and reversing aging, and the many practical ways you can promote your own longevity.Mark Hyman, M.D., joins Dave in Austin to talk all things longevity. Driven by his desire for a healthier, longer life for himself and others, Dr. Mark immersed himself in the latest scientific research on aging and longevity. Through his findings, he realized that the body has an incredible built-in healing system that can be activated through understanding the emerging science of longevity. He also managed to reduce his biological age by 20 years effectively.He consistently tackles the topic of inflammation and its impact on aging—or “Inflammaging” as he calls it. “The body only has so many ways to say ouch,” Dr. Mark says. “You have pain. You have inflammation. You have certain things that happen that create all these symptoms, but there're these common roots. So, inflammation is this common root that seems to accelerate as we get older. So, we can measure biomarkers of inflammation that are highly predictive of mortality.”This conversation covers many components of aging, like metabolic flexibility and resilience, mTor, meat- and plant-based protein, nutrition, environmental allergies and food sensitivities, histamine, autophagy, fasting, DEXA scans, and much more!In his book, "Young Forever: The Secrets to Living Your Longest, Healthiest Life,” Dr. Mark:shares the knowledge of how to unlock the causes of accelerated aging and treat it as a reversible disease.gives you practical tips for daily habits that will increase your energy and performance.teaches you why you age and what it really takes to live a longer, more vibrant life.Watch this episode on YouTube! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Dec 20231h 8min

In this episode of The Human Upgrade you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: Social connections are really good for you. Loneliness kills.It’s the quality of your close relationships that matters.Good close relationships don’t just protect your body, they protect your brain.Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:how relationships improve your physical, mental and emotional health. (More than you know!)how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)what social fitness is and how to practice it. (Yes, it’s a flex.)ways to enliven and energize your relationships. (Energy totally matters.)why casual and work relationships matter more than you think. (A surprisingly big contribution.)Watch this episode on YouTube!Don’t Miss This! Dr. Waldinger’s TEDtalk about the study is one of TED’s Top 10 episodes and viewed more than 43 million times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Dec 20231h 13min