Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes
Sznajder, Ł.J., Khan, M., Ciesiołka, A. et al. Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes. Nat Neurosci (2025...
29 Apr 202521min
EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation
Kim, D., Park, P., Li, X. et al. EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation. Nat Neurosci (2025).
29 Apr 202521min
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning
Mohar, B., Michel, G., Wang, YZ. et al. DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning. Nat Neurosci (2025)
29 Apr 202519min
Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease
This study identifies elevated CD38 expression on CD4+ T cells as a pre-symptomatic immunometabolic marker of Alzheimer’s disease and demonstrates that targeting CD38 in a mouse model restores immune ...
29 Apr 202520min
PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior
This study identifies excessive Pleiotrophin (PTN) released by dysregulated quiescent neural stem cells (qNSCs) as a key driver of manic-like behaviors in Shank3-overexpressing mice. Inhibiting PTN in...
29 Apr 202515min
Physical Activity, Affect, and Working Memory
This study found that daily physical behavior compositions—particularly time spent in moderate-to-vigorous physical activity (MVPA), light activity, and standing—were positively associated with improv...
29 Apr 202511min
Methylphenidate Promotes a Frontoparietal-Dominant Brain State Improving Cognitive Performance: A Randomized Trial
Methylphenidate (MP) is primarily prescribed for attention-deficit/hyperactivity disorder, but it is also misused as a cognitiveenhancer by individuals seeking to improve cognitive performance. Using ...
29 Apr 202512min
Feedback scales the spatial tuning of cortical responses during both visual working memory and long-term memory
We demonstrate that remembering a visual stimulus evokes responses in visual cortex that differ in spatial extent compared to seeing the same stimulus. Perception evokes tuned responses in early visua...
28 Apr 202511min
