GLP-1 Side Effects Aren't Inevitable: How to Avoid Them (with Dr. Matthea Rentea)

What if I told you that the side effects of nausea, constipation, muscle loss AND burnout on GLP-1s are not inevitable? That in many cases, they're simply a sign the medication is being used the wrong way?

In this week's episode of The Holistic GLP-1 Podcast, I sit down with Dr. Matthea Rentea—a double board-certified obesity medicine physician who is quietly revolutionizing how GLP-1s are used in clinical practice. This is one of the most nuanced, compassionate and empowering conversations we've had about how using GLP-1 medications can be part of a true healing journey—not a crash-and-burn weight loss strategy.

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SHOW NOTES

[ 00:00 ] Introduction

[ 01:20 ] How GLP-1s Changed Obesity Medicine

[ 05:05 ] Why Dr. Rentea Practices Holistic Medicine

[ 06:45 ] Dosing Strategy: Why The "Lowest Effective Dose" Works Best

[ 10:00 ] Carbohydrates, Insulin Resistance & Food Ordering

[ 13:40 ] How to Identify Insulin Resistance Early

[ 16:50 ] Why Side Effects Are Often Preventable

[ 18:40 ] Protein, Fiber & Protecting Muscle and Longevity

[ 22:20 ] Lean Mass vs. Skeletal Muscle Mass

[ 25:20 ] Bone Health, Strength Training & Aging

[ 28:30 ] Mindset, Identity & Behavior Change

[ 33:10 ] Dr. Rentea's Personal Weight Journey

[ 36:20 ] Are GLP-1s Lifelong?

[ 41:00 ] Can You "Re-sensitize" to GLP-1s?

[ 45:10 ] Genetics, Satiety Signaling & Healing Shame

[ 50:30 ] Supplements on a GLP-1 Journey

[ 54:50 ] What Real Success Looks Like on GLP-1s

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🔗 Mentioned in This Episode:

CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start

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Learn more about Dr. Matthea Rentea:

Website: https://www.renteaclinic.com/

Instagram: https://www.instagram.com/matthearenteamd/?hl=en