Integrative Lyme Solutions with Dr. Karlfeldt25 Helmi

Dr. Geoff Dow – New Clinical Trial for Chronic Babesiosis: Tafenoquine, Malaria Drugs, and Hope for Lyme-Linked Fatigue

Is chronic babesiosis finally getting the scientific attention it deserves?

In this episode of Integrative Lyme Solutions, Dr. K sits down with Dr. Geoff Dow, CEO & President of Sixty Degrees Pharmaceuticals, to discuss a groundbreaking clinical trial targeting chronic babesiosis — a common and often overlooked Lyme co-infection. Originally developed for malaria prevention, the drug Tafenoquine (brand name Kodatef®) is now being studied for its potential to treat persistent Babesia infections and Lyme-related fatigue.

They explore the science behind red blood cell parasites, how Babesia differs from malaria, why chronic babesiosis remains controversial, and what makes this new trial the first FDA-reviewed IND study focused on chronic disease. If you or a loved one struggle with Lyme-related fatigue, relapsing babesiosis, or limited treatment options, this conversation offers cautious optimism and a closer look at the future of targeted therapies.

Key Takeaways:

0:00 Introduction
3:10 From Malaria Drug Development to Lyme Co-Infections
6:45 How Babesia Infects Red Blood Cells and Causes Fatigue
10:40 Why Chronic Babesiosis Is Still Controversial
14:50 No FDA-Approved Drugs Specifically for Babesiosis
18:30 New Clinical Trials for Chronic and Relapsing Babesiosis
24:00 Measuring Fatigue as a Primary Endpoint in Chronic Disease

Resources Mentioned:

Sixty Degrees Pharmaceuticals - https://www.sixtydegreespharma.com
Kodatef® (Tafenoquine) Information - Available via company website above
Mount Sinai (Clinical Trial Site) - https://www.mountsinai.org
Yale Babesiosis Case Series (Referenced Study) - https://medicine.yale.edu

Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions.

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MORE PODCASTS FROM DR. KARLFELDT:

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