26. GLP-1 Series, Part 1: The Biology, the Drugs, and Why the Benefits Go Deeper Than the Scale

26. GLP-1 Series, Part 1: The Biology, the Drugs, and Why the Benefits Go Deeper Than the Scale

📝 Free Substack: mdlongevitylab.substack.com🌐 mdlongevitylab.com📸 @mdlongevitylab🎧 Subscribe, leave a 5-star review, and share this episode with one person who needs to hear it.GLP-1 medications are genuinely revolutionary — and genuinely misunderstood. The real conversation isn't hype or panic. In Part 1, we cover the evolutionary biology behind why these drugs work so powerfully, the full drug landscape from semaglutide to retatrutide, how to actually use the new oral pill formats correctly, and the systemic benefits that go far beyond the number on the scale. Part 2 drops alongside this one — don't skip it.

In this episode

Why our hunger biology was never built for the modern food environment — and what that means for obesity treatment

Semaglutide, tirzepatide, and retatrutide — the generation-by-generation breakdown, trial data, and side effect profile

Oral meds: why the 30-minute fasting window is pharmacologically non-negotiable

SELECT trial: 20% reduction in heart attacks and strokes — in patients without diabetes

Kidney protection, liver healing, sleep apnea, the Alzheimer's signal, and addiction medicine — what the evidence actually shows

"Food noise" isn't a metaphor — it's visible on brain MRI, and these drugs quiet it measurably.

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Jaksot(31)

31. The Evidence-Based Supplement Guide: Cutting Through the $60 Billion Noise

31. The Evidence-Based Supplement Guide: Cutting Through the $60 Billion Noise

The supplement industry is a $60 billion business with almost no regulatory oversight. Three out of four American adults take at least one. Almost none of them know what's actually in the bottle.In th...

4 Kesä 56min

30. The Delay Game: How Health Insurance Abandoned Your Healthcare & Why The Long Game of Prevention Belongs to You

30. The Delay Game: How Health Insurance Abandoned Your Healthcare & Why The Long Game of Prevention Belongs to You

The American health insurance industry is no longer in the business of paying for your healthcare. It is in the business of delaying it — long enough that someone else has to pay. Usually Medicare. Wh...

21 Touko 49min

29. The Statin You Fear vs. The Peptide You Trust: The Credibility Crisis in American Healthcare

29. The Statin You Fear vs. The Peptide You Trust: The Credibility Crisis in American Healthcare

This episode is a follow-up and expansion of Vikas's recent piece in STAT News on the same topic.Mention statins at a dinner party and you'll get muscle pain, brain fog, and Big Pharma conspiracies. M...

7 Touko 49min

28. Can You Out-Run Your Cocktail? Exercise, Alcohol, and the Science of Damage Control

28. Can You Out-Run Your Cocktail? Exercise, Alcohol, and the Science of Damage Control

Episode Title: Can You Out-Run Your Cocktail? Exercise, Alcohol, and the Science of Damage ControlCan exercise protect you from the damage alcohol does to your body? Drs. Vikas and Nisha Patel break d...

23 Huhti 49min

27. GLP-1 Series, Part 2: Muscle Loss, Weight Regain, and the Protocol That Actually Works

27. GLP-1 Series, Part 2: Muscle Loss, Weight Regain, and the Protocol That Actually Works

The real conversation about GLP-1 medications doesn't end with the prescription. Part 2 is where we get into the uncomfortable truths — the data on muscle loss, the biology of weight regain, the patie...

9 Huhti 1h 2min

25. Evolutionary Mismatch 101: Ancient Genes, Modern Diseases

25. Evolutionary Mismatch 101: Ancient Genes, Modern Diseases

🎉 One-Year Anniversary Episode 🎉It's our 25th episode and one-year podcast anniversary, and we're going to the foundation. Why are heart disease, cancer, Alzheimer's, diabetes, obesity, and depress...

12 Maalis 34min

24. Zones 1 & 2 Explained: How to Burn Visceral Fat Without Burning Out

24. Zones 1 & 2 Explained: How to Burn Visceral Fat Without Burning Out

🔔 Stay connected! https://www.mdlongevitylab.com/📲 Instagram: https://www.instagram.com/mdlongevitylab/📰 Substack: https://mdlongevitylab.substack.com/🎙️ Podcast: Available on Apple Podcasts, Spot...

26 Helmi 1h 4min

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