36. Why Dementia Prevention Beats Treatment: APOE Testing, Women's Brain Health, and the Levers You Control

36. Why Dementia Prevention Beats Treatment: APOE Testing, Women's Brain Health, and the Levers You Control

If you live into your mid-eighties, your odds of dementia are roughly one in three. Most people spend zero minutes of midlife thinking about it — and Dr. Vikas Patel and Dr. Nisha Patel make the case that's backwards, because nearly half of dementia risk traces to things you can actually change.

We get into APOE — the gene everyone's testing for and half the time misreading, and what one copy versus two really means. The badly under-told story of women's brain health: two-thirds of Alzheimer's is in women, the APOE4 gene hits them far harder than men, and menopause looks less like a reproductive event than a brain inflection point. The randomized-trial evidence that lifestyle protects cognition, even in gene carriers. And an honest look at the new Alzheimer's drugs, and why "slows decline by 27%" means far less than the headline suggests.

The brain you have at eighty-five is being built — or eroded — by the choices you're making at fifty. That's not scary. It's the most empowering sentence in medicine.


🎧 Listen on Apple Podcasts, Spotify, and YouTube📝 Subscribe: mdlongevitylab.substack.com📞 Book a 3-hour appointment: 224-208-3720📖 Book coming soon — by Dr. Vikas Patel. Stay tuned.📲 Follow @mdlongevitylab⚕️ MD Longevity Lab — Play the Long Game

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Jaksot(42)

42. The Long Game Against Cancer — Part 1: Our Why, The Stats, & The Case for Prevention

42. The Long Game Against Cancer — Part 1: Our Why, The Stats, & The Case for Prevention

The most personal series we’ve ever made. It opens with Nisha’s story — her blood cancer diagnosis eleven years ago — and reframes what cancer actually is: not an outside invader, but a breakdown of t...

5 Marras 37min

41. Short Takes: Exercise vs. Cancer, Statins After 70, Hormones & the Brain, and the Probiotic Paradox

41. Short Takes: Exercise vs. Cancer, Statins After 70, Hormones & the Brain, and the Probiotic Paradox

Welcome to Short Takes — an occasional format where Dr. Vikas Patel breaks down current medical news and new journal studies while they’re still current, in 15–20 minutes, and tells you what he’d actu...

22 Loka 18min

40. M.E.D Series Part 2: The Minimum Effective Dose: The Clap Back to the Overoptimizers

40. M.E.D Series Part 2: The Minimum Effective Dose: The Clap Back to the Overoptimizers

Part Two of the M.E.D. (minimum effective dose) Series — The minimum effective dose is the smallest amount of the right thing that captures the large majority of the benefit. Not the maximum. The mini...

8 Loka 1h 1min

39. M.E.D. Series, Pt. 1- The Overoptimization Trap: How the Wellness Industry Lost the Plot

39. M.E.D. Series, Pt. 1- The Overoptimization Trap: How the Wellness Industry Lost the Plot

Part One of the M.E.D. (minimum effective dose) Series. Dr. Vikas Patel and Dr. Nisha Patel take you up in the helicopter over the entire wellness industry — how it works, how it makes its money, and ...

24 Syys 1h 4min

38. Bone Health: Why Prevention Starts Decades Before Medicine Looks — Muscle, DEXA, and the Long Game

38. Bone Health: Why Prevention Starts Decades Before Medicine Looks — Muscle, DEXA, and the Long Game

Would you wait until sixty-four to check your retirement account for the first time? That's exactly what the medical system does with your bones — the first DEXA comes at sixty-five, after decades of ...

10 Syys 55min

37. Environmental Curveballs: Sorting Real Toxin Exposure Risk From the Noise

37. Environmental Curveballs: Sorting Real Toxin Exposure Risk From the Noise

Wildfire smoke. Cyclospora. Microplastics. Seed oils. Gas stoves. Every environmental scare that'll trend on your feed six weeks from now. Dr. Vikas Patel and Dr. Nisha Patel give you a four-question ...

27 Elo 51min

35. The Over-40 Injury Playbook: How to Prevent and Rehab Injuries When Life Hands You Lemons

35. The Over-40 Injury Playbook: How to Prevent and Rehab Injuries When Life Hands You Lemons

Anyone over 40 who's felt a tendon go knows the sound — and the sinking feeling right after. Why midlife makes us injury-prone: sedentary weekdays, weekend-warrior spikes, unstructured training, and m...

30 Heinä 1h 22min

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