HFpEF and HFmrEF: Can KCCQ-12 Replace KCCQ-23? | JACC Baran
JACC Global26 Touko

HFpEF and HFmrEF: Can KCCQ-12 Replace KCCQ-23? | JACC Baran

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Nobuhiro Ikemura, MD welcome Dr. Yasuhiro Hamatani, MD (Brigham and Women’s Hospital) to discuss his study, “Interchangeability of the KCCQ-12 and KCCQ-23 across >18,000 Participants Enrolled in 4 Large-Scale Trials of Heart Failure.” Using pooled patient-level data from TOPCAT, PARAGON-HF, DELIVER, and FINEARTS-HF, this study examined whether the shorter 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12) can reliably substitute for the more comprehensive KCCQ-23 in patients with HFmrEF and HFpEF. Across more than 18,000 participants, KCCQ-12 demonstrated extremely high correlation with KCCQ-23, comparable prognostic performance for cardiovascular death and heart failure hospitalization, and nearly identical estimates of treatment effect across multiple therapies and time points. The episode explores why patient-reported outcomes have become central to heart failure drug development, whether reducing questionnaire burden can improve implementation in trials and clinical practice, and how simpler digital health assessments may shape the future of patient-centered care in HFpEF and HFmrEF.

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Jaksot(82)

The Lancet: OPTIMA-AF, Is 1 Month Enough After PCI? | JACC Baran

The Lancet: OPTIMA-AF, Is 1 Month Enough After PCI? | JACC Baran

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, Nobuhiro Ikemura, MD, and Satoshi Shoji, MD, welcome Yohei Sotomi, MD, PhD (The University of Osaka), and Ken Kozuma, MD, PhD (Teikyo University) for a spe...

25 Elo 47min

HFpEF: Why Earlier May Be Better | JACC Baran

HFpEF: Why Earlier May Be Better | JACC Baran

Hosts Mitsuaki Sawano, MD, Nobuhiro Ikemura, MD, and Satoshi Shoji, MD welcome Shunichi Doi, MD (St. Marianna University School of Medicine) to discuss his JACC: Heart Failure study, Heart Failure Dur...

18 Elo 38min

Post-PCI Hematoma: What IVUS Tells Us | JACC Baran

Post-PCI Hematoma: What IVUS Tells Us | JACC Baran

Percutaneous coronary intervention (PCI) is safer than ever, yet coronary hematoma remains an underrecognized cause of early ischemic complications. In this episode, Host Mitsuaki Sawano, MD welcome T...

11 Elo 35min

Pediatric Heart Transplantation: When Priority Doesn't Match Urgency | JACC Baran

Pediatric Heart Transplantation: When Priority Doesn't Match Urgency | JACC Baran

Pediatric heart transplantation is one of medicine's scarcest resources, where every allocation decision can mean the difference between life and death. But does the current system truly prioritize th...

4 Elo 35min

PACs: Benign Bystanders or AF in Disguise? | JACC Baran

PACs: Benign Bystanders or AF in Disguise? | JACC Baran

Premature atrial complexes (PACs) are among the most common arrhythmias encountered in daily practice and are often dismissed as benign. But are they truly harmless—or could some represent the earlies...

28 Heinä 35min

Cancer VTE + DOAC: Who Will Bleed? | JACC Baran

Cancer VTE + DOAC: Who Will Bleed? | JACC Baran

Patients with active cancer face a difficult balance: preventing recurrent venous thromboembolism while avoiding major bleeding during anticoagulation. But which patients are truly at highest bleeding...

21 Heinä 39min

HFpEF Without Obesity: What Coronary Microcirculation Tells Us | JACC Baran

HFpEF Without Obesity: What Coronary Microcirculation Tells Us | JACC Baran

Host Mitsuaki Sawano, MD, welcomes Kai Nogami, MD (Mayo Clinic), to discuss his JACC Brief Report, "Higher Prevalence of Coronary Microvascular Dysfunction in Patients With HFpEF Without Obesity." Why...

14 Heinä 37min

What Autopsy Reveals About MINOCA and Sudden Cardiac Death | JACC Baran

What Autopsy Reveals About MINOCA and Sudden Cardiac Death | JACC Baran

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, Hiroyuki Sato, MD, and Shun Kosaka, MD welcome Dr. Kosuke Nakasuka, MD, PhD to discuss his JACC study, Sudden Cardiac Death Due to Myocardial Infarction W...

7 Heinä 45min

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