The Chronic Fatigue and Burnout Recovery Podcast21 Elo

Episode 157: Could Creatine Support Energy and Cognitive Function in Long Covid?

Creatine is often associated with the fitness industry and sports performance — but emerging research is now exploring whether it may have relevance far beyond the gym.

In this episode, Anna explores the current evidence surrounding creatine supplementation in Long Covid and fatigue-related conditions, including its potential role in energy metabolism, muscle function, cognitive symptoms, nervous system health, and recovery capacity.

This conversation also looks at:

Why creatine is being investigated in Long Covid
The link between ATP production and fatigue
Potential neuroprotective and antioxidant mechanisms
Brain fog and cognitive symptoms
Muscle weakness, PEM, and pacing considerations
Why individual responses to supplements can vary
Considerations around dosage, safety, and supplement sensitivity
Creatine and the menstrual cycle

Importantly, this episode takes a balanced and non-dogmatic approach. While early research is promising, creatine is not presented as a “magic bullet” or standalone solution for Long Covid.

As always, recovery is complex, individual, and multifactorial.

This episode is intended for educational purposes only and should not replace personalised medical advice.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: https://annamarsh.co.uk/

Referenced Articles

Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome

Reduced tissue creatine levels in patients with long COVID-19: A cross-sectional study

Creatine Supplementation in Women’s Health: A Lifespan Perspective

Creatine Supplementation and Brain Health

Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome

Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review

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Jaksot(158)

Episode 156: Recovery, Recalibration & Learning to Feel Safely Again

In this episode, Anna explores a side of recovery that is rarely discussed: What happens when the nervous system begins to reconnect with emotions, sensations, and internal experiences that were pr...

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Episode 155: What This New Research on Glutamate Might Mean for Long COVID & ME/CFS

In this episode, Anna breaks down a recent study exploring brain neurochemicals in Long COVID and ME/CFS — with a particular focus on glutamate and its potential role in symptoms, particularly physica...

24 Heinä 36min

Episode 154: Breakups, Dating & Recovery: Navigating Life After Long Covid with Lexi Boreham

In this episode, Anna is joined by Lexi Boreham, who shares her experience of living with and recovering from Long Covid. This conversation gently explores the reality of rebuilding a life alongsid...

10 Heinä 1h 1min

Episode 153: COMT - Why Some Nervous Systems Feel Everything More Intensely

Some people notice that they seem to experience stimulation and stress more intensely than others. They may feel overwhelmed in busy environments, react strongly to caffeine, or find it difficult t...

25 Kesä 13min

Episode 152: When You’re Mostly Better… But Not Fully Stable Yet

There is a stage of recovery that many people reach where life has largely returned to normal. You may be working again. Socialising more. Exercising gently. Participating in daily life in ways tha...

11 Kesä 22min

Episode 151: Why Gentle Movement Can Calm the Nervous System (Even With Chronic Fatigue)

Movement can feel like a complicated topic for people living with chronic fatigue conditions. Many people have been told to exercise more. Others have experienced crashes after pushing too hard. An...

29 Touko 27min

Episode 150: Relapse or Recalibration? Why Symptoms Can Return After Years of Stability

One of the most frightening moments in recovery can be when symptoms suddenly return after a long period of stability. And many people immediately think: "I’m back where I started." But in ma...

15 Touko 56min