Physical comorbidity in substance use disorder

Discover the fascinating world of benzodiazepines as we break down their metabolism, kinetics, and clinical impact. In this episode, we explore how the liver processes these commonly prescribed medications, highlighting the critical role of the cytochrome P4503A4 system. Learn why some benzodiazepines bypass phase 1 oxidation and how this affects their safety in elderly patients or those with liver disease. We also dive into the science of drug interactions, detailing how inhibitors and inducers of the SIP 3A4 enzyme can significantly alter plasma concentrations of benzodiazepines like diazepam. Plus, find out why tolerance develops, including uncoupling, receptor internalisation, and receptor insensitivity at the GABAA site. Whether you're a clinician or curious learner, this video equips you with essential knowledge on selecting the right benzodiazepine for specific conditions like anxiety, insomnia, or epilepsy. Don’t miss our insights into the dangers of long-term use and the development of tolerance.

9 Tammi 10min

Dive deep into the fascinating world of benzodiazepines with Dr. Ferghal Armstrong as we explore how these commonly prescribed medications function, their effects on the brain, and their clinical uses. Learn about the science behind GABA modulation, the differences between benzodiazepines and barbiturates, and why benzodiazepines are considered safer. We’ll uncover the secrets of their potency, half-lives, and why they’re used for conditions like anxiety, insomnia, and withdrawal management. You’ll also discover intriguing details about the GABA-A receptor, how benzodiazepines enhance its function, and the crucial distinctions between short-acting and long-acting benzodiazepines. Plus, we’ll discuss the potential risks when benzodiazepines are combined with opioids and how this can drastically increase overdose risks. Whether you’re a healthcare professional, a student, or just curious about pharmacology, this episode provides essential insights into benzodiazepines. Don't miss this educational journey into the science and safety of these vital drugs! Subscribe, comment, and share with anyone interested in understanding modern medicine better. Chapters 00:00 Introduction to Benzodiazepines 03:01 Understanding GABA and Benzodiazepine Mechanism 05:57 Comparative Potency and Half-Life of Benzodiazepines 09:09 Clinical Effects and Lethality of Benzodiazepines

2 Tammi 10min

Loneliness can have serious effects on your body. In this video, we'll explore the impacts of loneliness on your health and what you can do to combat it. Discover how social connections, resilience, and avoiding substance use disorder can help improve your well-being. Loneliness can be deadlier than smoking or excessive drinking? Discover why loneliness is more than just an emotion; it’s a significant risk factor for substance use relapse, increased suicide rates, strokes, heart attacks, and even diminished immunity. Learn from the Harvard study led by Robert Waldinger, which conclusively states that loneliness kills. Understand why your social connections affect your well-being far more profoundly than you ever imagined. 00:00:00 Introduction: Social Connections and Resilience 00:00:40 Effects of Loneliness 00:01:11 The Illusion of Social Media 00:02:00 Loneliness Compared to Smoking and Alcoholism 00:02:52 The Myth of Teflon Man 00:03:33 Harvard Study Findings: Importance of Relationships 00:05:20 Financial Success and Warm Relationships 00:06:27 Alcoholism and Longevity 00:07:18 Parenthood and Long-term Effects 00:08:14 Real-life Social Connections vs Social Media 00:09:52 Key Cognitions Affecting Social Connection 00:10:42 Supporting Opportunities for Social Contact 00:11:36 The Opposite of Addiction 00:12:23 Changing Peer Groups 00:13:32 The Famous Five: Essential Relationships in Recovery 00:15:06 Embracing Common Ground in Peer Support Groups 00:16:05 Conclusion: Unlocking the Power of Social Connection

25 Joulu 202416min

n this powerful interview, Dr. Samantha Harte reveals what nobody tells you about turning pain into power. She shares her journey through addiction recovery, mental health struggles, and the importance of a 12-step program. If you're a sober mom or struggling with substance abuse, this interview is a must-watch for insights and inspiration. Dr. Samantha Harte isn't just an expert—she's lived through the struggles herself, growing up in a family of addicts and dealing with issues like codependency and people-pleasing. She reveals how she turned her life around, becoming a bestselling author, a life coach, and a keynote speaker. Her book, "Breaking the Circuit: How to Rewire Your Mind for Hope, Resilience, and Joy in the Face of Trauma," offers a fresh take on the 12 steps, providing a modern spiritual template not just for addicts, but for everyone facing life's uncertainties and losses. For more information visit Dr Samantha Harte's website https://drsamanthaharte.com/ 00:00:01 Introduction to Dr. Samantha Harte 00:00:28 Dr. Harte's Professional Titles and Background 00:01:41 Personal Journey and Struggle with Addiction 00:03:00 Overdose and Catalyst for Change 00:04:22 15 Years of Sobriety and Recovery 00:05:35 Spiritual Journey and Professional Integration 00:06:09 Initial Resistance to 12-Step Program 00:08:14 Realising True Rock Bottom 00:10:20 The Hook: Returning to 12-Step Meetings 00:12:32 Struggles with Downers and Self-Realisation 00:13:46 Confronting Self-Ridicule and Perfectionism 00:14:18 Incorporating Wisdom into Professional Work 00:15:55 The Steps on Marriage and Personal Crisis 00:17:20 Learning Self-Forgiveness and Compassion 00:18:29 Application of 12 Steps in Everyday Situations 00:20:19 Bridging Ancient Practices with Modern Science 00:21:07 Universal Application of 12-Step Wisdom 00:21:43 Availability of Dr. Harte's Book

18 Joulu 202421min

Are you ready to transform your mental health and physical wellbeing? In this episode of Cracking Addiction, we dive deep into the powerful role of positivity, meaningful activity, and strong relationships in enhancing your life. If you've ever struggled with poor mental health or have been curious about how to improve your happiness, you're in the right place! Let's talk about how simple lifestyle changes, like adding those famous 10,000 steps and reducing leisure inactivity, can directly impact your well being. Keywords like "mental health" and "physical wellbeing" take center stage as we explore their intertwined connection. Ever wondered why "sitting is the new smoking"? You'll discover shocking insights that will make you rethink your daily habits. Alongside, we unravel the vicious cycle of alcohol consumption and its detrimental effects on mental health. But that's not all—we'll delve into Martin Seligman's PERMA model, showing you how positivity and engagement in meaningful activities can drastically change your life. This video isn't just informative; it's a roadmap to a healthier, happier you. 00:00:00 Introduction to Well Being and Poor Mental Health 00:00:30 Origins of the 10,000 Steps Concept 00:01:07 Relationship Between Steps and Mortality 00:01:50 The Harm of Leisure Time Inactivity 00:02:13 Sitting as the New Smoking 0 0:03:10 Harmful Alcohol Consumption and Mental Health 00:03:50 Alcohol Consumption Guidelines in Australia and Canada 00:04:05 The PERMA Model by Martin Seligman 00:05:03 Developing Positivity Through Deliberate Practices 00:06:05 Importance of Engagement in Meaningful Activities 00:07:23 Relationship Between Loneliness and Meta-Inflammation 00:08:53 Impact of Adverse Childhood Experiences on Well being 00:09:32 Benefits of High Well Being 00:10:09 Summary and Conclusion

12 Joulu 202410min

Are you ready to dive deep into the multidimensional concept of well-being and discover actionable steps to enhance your life? In this episode of Cracking Addiction, I uncover the secrets to achieving ultimate well-being by examining the vital role of genetics and the impactful behaviours you can adopt today. From physical fitness and dieting strategies to the importance of social connections and lifestyle choices, you'll find out exactly how to boost your mental and physical health! Throughout this video, we explore the genetic influence on well-being, revealing that at least a third of our life satisfaction and wellness are inherited. You'll learn the significance of commuting physical activity, the power of a vegetable-rich diet, and the impact of abstaining from tobacco and alcohol. Each proven tip is designed to elevate your life, making this video a must-watch for anyone looking to improve their quality of life. 00:00:00 Introduction to Well Being 00:00:54 Definitions of Well Being 00:01:48 Genetic Influence on Well Being 00:02:58 Behavioural Determinants of Well Being 00:03:43 Activities Reducing Well Being 00:04:25 Alcohol Consumption and Well Being 00:04:53 Government Physical Activity Recommendations 00:05:34 Diet and Well Being 00:06:26 Tobacco and Well Being 00:07:07 Summary and Conclusion

5 Joulu 20247min

In this eye-opening episode of "Cracking Addiction", we dive deep into the complex world of gambling addiction. We'll explore risk factors, diagnostic criteria, and effective treatment options—both psychological and pharmacological. You won't want to miss this comprehensive guide on tackling gambling addiction. According to the Australian Institute of Health and Welfare, Australians lose around $25 billion annually to legal forms of gambling. That's astonishing! With 75% of adults engaging in some form of gambling, the impact is massive. I break down gambling statistics, risk factors, and comorbidities like mental health disorders and substance use, making it clear that gambling addiction is a significant issue. Wondering about how to diagnose gambling addiction? I cover valuable tools like the Lie Bet questionnaire and the Problem Gambling Severity Index (PGSI). Understanding criteria from DSM-5, I use the mnemonic "CLERIC R.I.P." to make it easier for you to remember the signs. From CBT to motivational interviewing, and even pharmacotherapy like opioid antagonists and antidepressants, I unpack every viable treatment. 00:00:00 Introduction and Scope of the Problem 00:00:59 Risk Factors for Gambling Disorder 00:02:51 Assessing Gambling Disorder 00:04:04 DSM-5 Criteria for Gambling Disorder 00:05:43 Understanding Low Risk Gambling 00:06:37 Subtypes of Gambling Disorder 00:07:19 Cognitive Behavioral Therapy (CBT) for Gambling 00:08:12 Motivational Interviewing 00:09:01 Pharmacological Treatments 00:10:59 Available Help Resources in Australia 00:11:48 Conclusion and Final Thought

27 Marras 202412min

Welcome to Cracking Addiction; in this video, we dive deep into the world of prudent diets, revealing how you can naturally improve your heart and brain health. From understanding the Mediterranean diet’s benefits to exploring the DASH diet's effectiveness in lowering blood pressure, you'll get a comprehensive look at how specific foods contribute to your overall well-being. Plus, we introduce you to the cutting-edge MIND diet, a fusion designed to protect against neurodegeneration and enhance cognitive function. If you’re fascinated by the connection between food and health, this video is just for you! In just a few sentences, you'll discover why the DASH, Mediterranean, and MIND diets are essential for those serious about heart and brain health. These prudent diets will give you actionable tips to enhance your wellness journey right now!

20 Marras 202410min