The Science of Mood And Your Microbiome with Dr. Uma Naidoo

For decades, psychiatry has relied on treatments that are slow and often ineffective. But what if one intervention could reset the brain, break the grip of addiction, and open the door to an entirely new model of care? On this episode of The Dr. Hyman Show, I sit down with Dr. Nolan Williams, a Stanford neuropsychiatrist pioneering new therapies for substance use disorders, depression, PTSD, and traumatic brain injury. We dive into these fascinating topics and more; watch the full conversation on YouTube or listen wherever you get your podcasts. You’ll learn: • Why ibogaine is unlike any other psychedelic—and how it could reset the brain • Its promise for treating substance abuse disorders and breaking cycles of addiction • The safety step that makes ibogaine treatment possible for real patients • Why psychiatry is shifting from trial-and-error to targeted brain circuits Talks like this remind me just how close we are to real breakthroughs in mental health. Dr. Williams calls it psychiatry 3.0. It’s a new era of treatments that actually heal the brain, and it gives me great hope for the future of medicine. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Seed, Sunlighten, Function Health,Timeline, AirDoctor and Pique. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Visit sunlighten.com and save up to $1400 on your purchase with code HYMAN. Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today. Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman. Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman.

3 Syys 1h 20min

Nutrients are far more than supplements on a shelf—they are life-sustaining molecules that determine how well the body ages and resists disease. For years, their importance was overlooked because many studies were poorly designed, failing to consider existing nutrient levels or how vitamins and minerals work together. Strong evidence now shows multivitamins can slow brain aging, omega-3s can extend life expectancy, and shortages of vitamin D, magnesium, and B12 are widespread drivers of inflammation and chronic illness. Knowing and addressing individual deficiencies is critical, as these nutrients power billions of chemical reactions every second and are foundational to vitality and longevity. In this episode, I discuss, along with Dr. Rhonda Patrick and Steve Martocci, why nutrients are essential for a healthy body and how to choose the highest quality supplements. Dr. Rhonda Patrick is a scientist and health educator recognized for her leadership in aging and disease prevention. As the founder of FoundMyFitness, she provides evidence-based insights to a global audience through her website and podcast. On YouTube, she engages millions in in-depth discussions on evidence-based strategies for well-being. Dr. Patrick’s focus areas include genetic influences in dietary response, micronutrients, sleep, non-pharmacological approaches to mental well-being, and the surprising and paradoxical benefits of biological stressors such as exercise, heat, cold exposure, and plant phytochemicals. As an associate scientist and board member at the Fatty Acid Research Institute, she advances understanding of omega-3 fatty acids in aging and health. Her research has been published in high-impact journals like Nature Cell Biology, Experimental Gerontology, and FASEB. Steve Martocci is the co-founder and CEO of Suppco, a smart supplement tracking platform helping people take the right supplements with confidence. After years of struggling with his health and hitting 300 pounds, Steve turned to functional medicine and supplements to reclaim his well-being. That personal transformation—and the confusion he faced along the way—inspired him to build Suppco. Suppco helps users track what they’re taking, avoid unnecessary or low-quality products, and personalize their supplement routine with tools like brand TrustScores, protocol guides, and stack analysis. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here: The Nutrient Gaps That Could Be Aging You Faster My Favorite Supplements for Optimal Health & Longevity How to Choose the Right Supplements (and Avoid the Wrong Ones)

1 Syys 59min

It’s been five years since Ben Greenfield joined me on The Dr. Hyman Show, and a lot has changed. Ben isn’t doing many of the things he once swore by. In fact, he’s discovered that some of the most powerful practices for health and longevity are simpler and more sustainable than the extreme routines he became known for.  In this episode, we talk about the biohacks he’s left behind, the innovations he still uses, and the deeper priorities that now guide his life. Join us on YouTube for the full talk or listen wherever you get your podcasts. [YOUTUBE THUMBNAIL] We discuss: • How much exercise is truly healthy, and when it starts working against you • Simple training shifts that build strength and stamina while protecting long-term health • What recovery tools can actually speed healing and reduce inflammation • Can light and oxygen really reset your body’s rhythms and improve sleep? • Why community, family, and spiritual health may be the most overlooked keys to longevity True longevity isn’t found in extremes—it’s built through balance, connection, and simple daily practices that stand the test of time. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by  Sunlighten, Paleovalley, Function Health,Timeline, AirDoctor and LMNT. Visit sunlighten.com and save up to $1400 on your purchase with code HYMAN. Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase. Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today. Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman. Get a free LMNT Sample Pack with any order—just head to drinklmnt.com/hyman.

27 Elo 1h 25min

As women enter perimenopause and menopause, hormonal shifts—declining estrogen, progesterone, and testosterone—can ripple through nearly every system in the body, impacting bone density, cardiovascular health, metabolism, brain function, and sexual wellbeing. Misinterpretation of past research left millions fearful of hormone therapy, yet newer evidence shows that bioidentical hormones, started within a specific “window of opportunity,” can protect the heart, brain, bones, and quality of life. Supporting this transition in a woman’s life also means addressing nutrition, gut health, stress, sleep, and strength training—powerful tools that work alongside hormones to restore vitality. With the right knowledge and care, this phase of life can be transformational, leading to renewal, resilience, and long-term health protection. In this episode, I explore, along with Dr. Mary Claire Haver and Dr. Cindy Geyer, how we can shift our thinking of peri-menopause and menopause to one of renewed health and vitality. Mary Claire Haver, MD, FACOG, CMP, is a board-certified Obstetrician and Gynecologist, Certified Culinary Medicine Specialist, and Menopause Society Certified Menopause Practitioner. A graduate of Louisiana State University Medical Center with residency at the University of Texas Medical Branch, she is the founder of Mary Claire Wellness, a clinic dedicated to comprehensive menopause care. In 2023, she launched ThePauseLife.com, a global resource for menopausal women, and became a #1 New York Times bestselling author with The New Menopause. Her first book, The Galveston Diet (2023), reflects her passion for evidence-based lifestyle strategies to support women’s health. With over 4 million social media followers, Dr. Haver is a leading voice in “demystifying menopause,” empowering women to self-advocate and thrive through every stage of midlife. Dr. Cindy Geyer received her bachelor of science and her doctor of medicine degrees, with honors, from the Ohio State University. She completed residency in internal medicine at Strong Memorial Hospital in Rochester, N.Y. and is triple board certified in internal medicine, integrative medicine and lifestyle medicine. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here: Your Guide to Menopause: What to Expect and How to Thrive Menopause Relief: Hormone Tips Every Woman Needs To Know Is Hormone Replacement Therapy in Menopause Helpful or Harmful

25 Elo 55min

In a world where healthcare often focuses on treating illness rather than promoting wellness, what does it really take to live a healthy, vibrant life? In this episode of The Dr. Hyman Show, I sit down with John Mackey, co-founder of Whole Foods Market, to explore his journey from building one of America’s most iconic food companies to rethinking health, purpose, and consciousness. We talk about his new venture, Love.Life, and how it fits into a bigger philosophy that includes conscious capitalism and living with meaning. You can catch our full conversation on YouTube or listen wherever you get your podcasts. We unpack: • What psychedelic insights can teach you about health and consciousness • How conscious capitalism can create “win-win-win” outcomes in your life • Steps you can take to break free from habits driving weight gain and poor health • Why building the right community accelerates your health journey • What living with purpose can do for your well-being at every stage of life This conversation reinforces a belief we both share: that true health comes from love, community, and a comprehensive approach.  View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Seed, PerfectAmino, Function Health, BON CHARGE, Big Bold Health and Pique. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Go to bodyhealth.com and use code HYMAN20 for 20% off your first order. Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership. Head to boncharge.com and use code DRMARK for 15% off your order. Get 30% off HTB Immune Energy Chews at bigboldhealth.com and use code DRMARK30. Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman.

20 Elo 1h 3min

Relationships have the power to change lives in ways both visible and hidden. Deep, supportive bonds can quiet inflammation in the body, protect against disease, and anchor people through decades of triumphs and trials. Communities that come together—whether in small groups at a church or around a shared health goal—often achieve far more than individuals working alone, sometimes transforming their health on a massive scale. Lifelong friends celebrate each other’s victories without jealousy, weather hardship side by side, and dare to speak difficult truths even at the risk of the relationship. Yet, many remain in unfulfilling connections out of fear of loneliness, forgetting that genuine, vulnerable connection is not just emotionally nourishing—it is essential to human health and resilience. In this episode, I talk with Simon Sinek, Esther Perel, and Angelika Alana about how relationships are vital not just for emotional health, but for physical wellbeing and can be a great source of growth and healing. Simon is a spark that ignites passion and ideas. He envisions a world where people wake up inspired, feel safe, and end their day fulfilled. As an unshakeable optimist and trained ethnographer, Simon is fascinated by people and organizations that make a lasting impact. He has discovered remarkable patterns in how they think, act, and communicate, revealing how people perform at their best. Simon is widely known for his TED Talk on "WHY" and his viral video on millennials in the workplace. Through bestselling books like Start with WHY and his podcast A Bit of Optimism, he continues to inspire. Founder of The Optimism Company and Optimism Press, Simon shares innovative views on leadership, attracting international attention. He also works with the U.S. government, the RAND Corporation, and in 2021, founded The Curve to reform modern policing, advancing justice with dignity, equity, and fairness. Psychotherapist and New York Times bestselling author Esther Perel is recognized as one of today’s most insightful and original voices on modern relationships. Fluent in nine languages, she helms a therapy practice in New York City and serves as an organizational consultant for Fortune 500 companies around the world. Her celebrated TED Talks have garnered more than 30 million views and her bestselling books, Mating in Captivity and The State of Affairs, are global phenomena translated into nearly 30 languages. Esther is also an executive producer and host of the popular podcasts Where Should We Begin? and How’s Work? Her latest project is Where Should We Begin - A Game of Stories with Esther Perel. Angelika Alana is the founder and CEO of the Somatic Healing Institute. She has been featured in Vanity Fair, Well+Good, and Modern Luxury. She certifies coaches and facilitators in her transformational body-based healing method. She has traveled and studied extensively in Indonesia, Brazil, Australia, and the UK, and is a massive foodie with her husband Patrick Drake, co-founder of Hello Fresh. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here: Simon Sinek on the Power of Relationships for Longevity How To Have Successful Relationships How To Move From Toxic Relationships And Sex To Healing Relationships And Sex

18 Elo 1h 7min

With so much conflicting health advice online, it’s no wonder people feel overwhelmed by food choices. Is saturated fat really the enemy? Are seed oils as harmful as some headlines claim? And how do we know what’s actually true?  In this episode of The Dr. Hyman Show, I sit down with nutrition researcher and author Simon Hill to make sense of the latest science and help you cut through the confusion. You can watch our full conversation on YouTube or listen wherever you get your podcasts. We discuss: • The real story behind seed oils, saturated fat, and inflammation—and what to do about it • What your lab work can tell you about your unique nutrition needs • How to spot nutrition misinformation and think critically about food trends • Why cutting back on ultra-processed foods may be more important than obsessing over any single nutrient In a world full of nutrition noise, this episode helps you tune into what really matters—science, and your own body. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks? utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Fatty15, Paleovalley, Function Health, AirDoctor, Timeline and Pique. Head to fatty15.com/hyman and use code HYMAN for 15% off your 90-day subscription Starter Kit. Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase. Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership. Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today. Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman.

13 Elo 1h 20min

Medicine stands at the threshold of a new era, where artificial intelligence and systems biology are working hand in hand to make care more personal, predictive, and precise than ever before. AI is already improving diagnostic accuracy, automating administrative tasks, and uncovering patterns in data—like retinal scans or genomics—that humans often miss. Rather than replacing doctors, AI enhances their ability to deliver more informed, precise, and efficient care. At the same time, individuals are gaining tools—from at-home diagnostics to wearable biosensors—that empower them to track and optimize their own health. This shift marks a move from reactive, disease-centered care to a proactive, data-driven model of scientific wellness. In this episode, I talk with Dr. Eric Topol, Dr. Nathan Price, Dr. Leroy Hood, Dr. Vijay Pande, and Daisy Wolf about how artificial intelligence, personalized data, and wearable technology are converging to radically transform medicine. Dr. Eric Topol is Executive Vice President of Scripps Research and founder/director of its Translational Institute, recognized as one of the top 10 most cited researchers in medicine with over 1,300 publications. A cardiologist and author of several bestselling books on the future of medicine, he leads major NIH grants in precision medicine and shares cutting-edge biomedical insights through his Ground Truths newsletter and podcast. Dr. Nathan Price is Chief Scientific Officer at Thorne HealthTech, author of The Age of Scientific Wellness, and a National Academy of Medicine Emerging Leader. He also serves on the Board on Life Sciences for the National Academies and is Affiliate Faculty in Bioengineering and Computer Science at the University of Washington. Dr. Leroy Hood is CEO and founder of Phenome Health, leading the Human Phenome Initiative to sequence and track the health of one million people over 10 years. A pioneer in systems biology and co-founder of 17 biotech companies, he is a recipient of the Lasker Prize, Kyoto Prize, and National Medal of Science. Dr. Vijay Pande is a General Partner at Andreessen Horowitz and founder of a16z Bio + Health, managing over $3 billion in life sciences and healthcare investments at the intersection of biology and AI. An Adjunct Professor at Stanford, he is known for his work in computational science, earning honors like the DeLano Prize and a Guinness World Record for Folding@Home. Daisy Wolf is an investing partner at Andreessen Horowitz, specializing in healthcare AI, consumer health, and healthcare-fintech innovation. She previously worked at Meta and in various startups, holds a JD from Yale Law, an MBA from Stanford, and a BA from Yale, and is based in New York City. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: Can AI Fix Our Health and Our Healthcare System? The Next Revolution In Medicine: Scientific Wellness, AI And Disease Reversal The Future of Healthcare: The Role of AI and Technology

11 Elo 1h 4min