Metformin, Insulin Resistance and Bipolar depression: From research to clinical care

Dr. Cynthia Calkin's study using Metformin in treatment-resistant Bipolar Disorder showed that improving insulin resistance dramatically improved depression outcomes. This research is helping shift the paradigm for how we treat bipolar disorder. Her clinical practice and research studies demonstrate that metabolic dysfunction significantly contributes to mental illness and, perhaps even more importantly, that treating metabolic dysfunction results in significant symptomatic improvements.

This is a dramatic clinical shift in psychiatry, and as you will hear, it has been slow to catch on within the psychiatry community. But with Dr. Calikn’s research and her desire to help as many people as possible, Dr. Calkin is helping spread the word so more clinicians understand the benefit of approaching patients from a metabolic perspective.

Studies referenced in this video:

Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression (the TRIO-BD Study): A Randomized, Quadruple-Masked, Placebo-Controlled Clinical Trial https://pubmed.ncbi.nlm.nih.gov/35120288/

Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/34113269/

Table of Contents:

0:00 - Introduction

1:57 - Interview with Dr. Cynthia Calkin

46:06 - Conclusion

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Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/

About us:

Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders.

Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

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