Episode 296: 295. What is the Best Blood Pressure In the Nursing Home?

Episode 296: 295. What is the Best Blood Pressure In the Nursing Home?

In a retrospective cohort study of Veterans Affairs (VA) nursing home residents during 2006 to 2019, researchers identified 13,000 residents who initiated a first or additional antihypertensive medication and 52,000 propensity score–matched controls (mean age, 78). The primary outcome was a composite of pelvic fracture, surgically treated hip fracture, and fractures of the humerus, radius, and ulna that required intervention within 30 days of starting antihypertensive medication.

Initiating medication also was associated with elevated risks for falls that required emergency room visits or hospitalizations (aHR, 1.8) and elevated risks of syncope (aHR, 1.7).

Fracture risks were elevated, compared with controls, in initiators with a systolic blood pressure ≥140 mm Hg (aHR, 3.1), diastolic blood pressure ≥80 mm Hg (aHR, 4.4), and no recent antihypertensive medication use (aHR, 4.8).

Jaksot(386)

Episode 319: 318. Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide

Episode 319: 318. Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutidethis paper out in JAMA makes you think this is an issue but likely just too much noise with only 17 patietns a...

17 Heinä 20249min

Episode 318: 317. METHODS MONDAY- What is a Confounder?

Episode 318: 317. METHODS MONDAY- What is a Confounder?

Be careful, most observational data have a large amount of confounders not accounted for and even when accounted for you can never account for all the confounders

15 Heinä 202410min

Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease

Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease

https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251. Diagnosis:To establish a PAD diagnosis, the resting ankle–brachial index (ABI) remains the initial test of choice in patients with suggest...

10 Heinä 20245min

Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population

Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population

https://jamanetwork.com/journals/jama/article-abstract/2818624Conclusion--“Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. The addition ...

9 Heinä 20246min

Episode 315: 314. METHODS MONDAY! What Is A C-Score?

Episode 315: 314. METHODS MONDAY! What Is A C-Score?

What are c statisticsC-statistic gives the probability a randomly selected patient who experienced an event (e.g. a disease or condition) had a higher risk score than a patient who had not experienced...

8 Heinä 20247min

Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

https://pubmed.ncbi.nlm.nih.gov/38598573/In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptomatic COVID-19, does paxlovid--nirmatrelvir-ritonav...

5 Heinä 20245min

Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

https://www.nejm.org/doi/10.1056/NEJMoa2314063Randomized trials have shown the benefit of endovascular thrombectomy in patients with acute stroke due to large-artery occlusion in the anterior circulat...

3 Heinä 20247min

Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception

Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception

https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.124.047438We studied the risk of IS and ICH in women using LG-IUDs—aka mirana-- compared to women not using hormonal contraceptives.  The commonl...

2 Heinä 20245min

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