Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Jaksot(385)

Episode 318: 317. METHODS MONDAY- What is a Confounder?

Episode 318: 317. METHODS MONDAY- What is a Confounder?

Be careful, most observational data have a large amount of confounders not accounted for and even when accounted for you can never account for all the confounders

15 Heinä 202410min

Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease

Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease

https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251. Diagnosis:To establish a PAD diagnosis, the resting ankle–brachial index (ABI) remains the initial test of choice in patients with suggest...

10 Heinä 20245min

Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population

Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population

https://jamanetwork.com/journals/jama/article-abstract/2818624Conclusion--“Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. The addition ...

9 Heinä 20246min

Episode 315: 314. METHODS MONDAY! What Is A C-Score?

Episode 315: 314. METHODS MONDAY! What Is A C-Score?

What are c statisticsC-statistic gives the probability a randomly selected patient who experienced an event (e.g. a disease or condition) had a higher risk score than a patient who had not experienced...

8 Heinä 20247min

Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

https://pubmed.ncbi.nlm.nih.gov/38598573/In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptomatic COVID-19, does paxlovid--nirmatrelvir-ritonav...

5 Heinä 20245min

Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

https://www.nejm.org/doi/10.1056/NEJMoa2314063Randomized trials have shown the benefit of endovascular thrombectomy in patients with acute stroke due to large-artery occlusion in the anterior circulat...

3 Heinä 20247min

Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception

Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception

https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.124.047438We studied the risk of IS and ICH in women using LG-IUDs—aka mirana-- compared to women not using hormonal contraceptives.  The commonl...

2 Heinä 20245min

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