Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Jaksot(385)

Episode 310: 309. Hospital-Associated Venous Thromboembolism Prophylaxis Use by Risk Assessment

Episode 310: 309. Hospital-Associated Venous Thromboembolism Prophylaxis Use by Risk Assessment

https://shmpublications.onlinelibrary.wiley.com/doi/abs/10.1002/jhm.13350Xu J et al. Hospital-associated venous thromboembolism prophylaxis use by risk assessment at a large integrated health care net...

28 Kesä 20248min

Episode 309: 308. Mailed feedback to Primary Care Physicians on Antibiotic Prescribing

Episode 309: 308. Mailed feedback to Primary Care Physicians on Antibiotic Prescribing

https://www.bmj.com/content/385/bmj-2024-079329Overprescription of antibiotics by primary care clinicians is a major modifiable driver of antibiotic resistance. Evidence suggests that peer-comparison ...

27 Kesä 20247min

Episode 308: 307. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES)

Episode 308: 307. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES)

Kityo C et al. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): Week 48 results from a randomised, multicentre, open-label, non-inferio...

25 Kesä 20245min

Episode 307: 306. METHODS MONDAY! What is the 95% Confidence Interval?

Episode 307: 306. METHODS MONDAY! What is the 95% Confidence Interval?

95% CI does NOT mean there is a 95% chance the true value is in the interval. It means that if you continually resample, 95% of your confidence intervals (which will vary every time you resample), wil...

24 Kesä 20248min

Episode 306: 305. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

Episode 306: 305. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae290/7685305?login=trueChildren aged 1-18 years to prevent rickets and to potentially lower the risk for respiratory tract infection...

21 Kesä 202414min

Episode 305: 304. METHODS MONDAY- What is Power?

Episode 305: 304. METHODS MONDAY- What is Power?

What is the power of a study—what is the power calculation? Often say it is the number of people in a study. Power is the probably to correctly reject the null hypothesis. Said differently power is th...

17 Kesä 202415min

Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes

Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes

Question  What is the strength of association between surrogate markers used as primary end points in clinical trials to support Food and Drug Administration (FDA) approval of drugs treating nononcolo...

14 Kesä 20245min

Episode 303: 302. Effects of statin therapy on diagnoses of new-onset diabetes

Episode 303: 302. Effects of statin therapy on diagnoses of new-onset diabetes

The incidence of new-onset diabetes was basically the same but statistically significantly higher for those individuals on low-to-moderate–intensity statins compared with placebo 1.2 vs 1.3% annually ...

13 Kesä 20246min

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