Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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126. Corona Virus, COVID19, Pregnancy, Pre-symptomatic Spread

126. Corona Virus, COVID19, Pregnancy, Pre-symptomatic Spread

More cover 19 information based on antibody testing, pregnancy and pre-symptomatic spreadhttps://www.medrxiv.org/content/10.1101/2020.03.30.20047365v1.full.pdfhttps://www.nejm.org/doi/full/10.1056/NEJ...

20 Huhti 202025min

125. Remdesivir, Covid19, Corona Virus, NEJM Treatment

125. Remdesivir, Covid19, Corona Virus, NEJM Treatment

Remdesivir for compassionate use?? Recently published in the New England Journal of Medicine- Is this the COVID19 treatment we have all be hoping for.https://www.nejm.org/doi/full/10.1056/NEJMoa200701...

14 Huhti 202023min

124. COVID19, Corona Virus and TREATMENT (that works)

124. COVID19, Corona Virus and TREATMENT (that works)

Treatment that works-- MASK!https://annals.org/aim/fullarticle/2764367/effectiveness-surgical-cotton-masks-blocking-sars-cov-2-controlled-comparisonHigh Velocity Nasal Insufflation (HVNI) Therapy Appl...

10 Huhti 202016min

123. COVID19, ACE inhibitors, Corona Virus, Testing

123. COVID19, ACE inhibitors, Corona Virus, Testing

Id be happy to send you links to any of the articles talked about in this podcast but I cover the new test on the corona virus that claims to be great but the devil in the details as well as talk abou...

9 Huhti 202019min

122. Hydroxychloroquine, COVID19, Coronavirus, research

122. Hydroxychloroquine, COVID19, Coronavirus, research

https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v1.full.pdf https://www.sciencedirect.com/science/article/pii/S0399077X20300858 https://first10em.com/chloroquine-for-covid-no-good-evidence-...

3 Huhti 202016min

121. COVID19, Hydroxychloroquine, Azithromycin, Coronavirus, TREATMENT

121. COVID19, Hydroxychloroquine, Azithromycin, Coronavirus, TREATMENT

https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-000890-25/FRhttps://www.sciencedirect.com/science/article/pii/S0924857920300996?via%3Dihub

26 Maalis 202021min

120. Question Everything- Stop Hear-Say medicine

120. Question Everything- Stop Hear-Say medicine

Question Everything-- EBM not hear-say medicine

24 Maalis 202024min

119. Aimovig or Erenumab Prescription Description

119. Aimovig or Erenumab Prescription Description

A listener wrote in with a question about a drug, this is my response. Let me know your thoughts? Would you prescribe this drug? Andrewbuelt@gmail.comhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1705848

13 Maalis 202024min

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