Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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118. Choosing Wisely, Statins for Stroke, and Physical Therapy first

118. Choosing Wisely, Statins for Stroke, and Physical Therapy first

There was a paper to start the year that got a lot of hype saying that just maybe we should target an LDL but that is not what the study actually showed and I will tell you why I think it is wrong.

8 Maalis 202022min

117. The Benefits on Healthy lifestyle and Nutrition

117. The Benefits on Healthy lifestyle and Nutrition

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2757311?widget=personalizedcontent&previousarticle=2757307 Prior authorization requirements increased from 8% to approximately 24% of...

1 Maalis 202034min

116. Conflicts of Vaccine, Understanding Sunscreen, and UPTODATE

116. Conflicts of Vaccine, Understanding Sunscreen, and UPTODATE

https://annals.org/aim/fullarticle/2760034/disclosure-form-work-submitted-medical-journals-proposal-from-international-committee. disclose everything for the papers that you keep..or writePatient comp...

25 Helmi 202022min

115. Part 3 of the Top Articles of 2019

115. Part 3 of the Top Articles of 2019

Try not to read these all at once!!https://www.ncbi.nlm.nih.gov/pubmed/30715088 https://www.bmj.com/content/365/bmj.l2006 https://www.ncbi.nlm.nih.gov/pubmed/30359476 https://www.ncbi.nlm.nih.gov/pub...

11 Helmi 202022min

114. Top Articles of 2019 Part 2

114. Top Articles of 2019 Part 2

No summary YET! I promise it is coming, but here are a few more articles I think were pretty impressive from 2019.

4 Helmi 202019min

113. Top articles of 2019 part 1

113. Top articles of 2019 part 1

It is that time of year again-- Top articles of 2019 part 1. This is my opinion, but I think it is a pretty good opinion.

24 Tammi 202022min

112. Grade B, COPD, and Facebook for HIV

112. Grade B, COPD, and Facebook for HIV

https://jamanetwork.com/journals/jama/fullarticle/2751726 uspstf now grade B for asymptomatic urine in preggohttps://pediatrics.aappublications.org/content/144/6/e20192739kids do shoot their eye out!h...

17 Tammi 202026min

111. Dulaglutide, IVC Filter, Polypoll for Primary Prevention, and Afib Antithrombotic Therapy

111. Dulaglutide, IVC Filter, Polypoll for Primary Prevention, and Afib Antithrombotic Therapy

https://www.nejm.org/doi/full/10.1056/NEJMoa1806515-- IVC filter after a severe injury = it is ok to wait 7 dayshttps://www.nejm.org/doi/full/10.1056/NEJMoa1904143antithrombotic therapy with afib afte...

12 Joulu 201925min

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