Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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110. 3 Papers The Authors Got Wrong

110. 3 Papers The Authors Got Wrong

https://www.ncbi.nlm.nih.gov/pubmed/31550435 mono and athletes -- stick with 21 dayshttps://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32738 Hair Dye does not cause breast cancerhttps://jamanetwork...

6 Joulu 201923min

109. Be Thankful One Article Will Change Your Practice

109. Be Thankful One Article Will Change Your Practice

https://jamanetwork.com/journals/jama/article-abstract/2753909?guestAccessKey=03d877eb-6d48-476f-9487-aa6fbbd8a8d5&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=o...

28 Marras 201921min

108. Blood Cultures, Patiromer, and Pregnancy

108. Blood Cultures, Patiromer, and Pregnancy

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2753986?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=110619  mailing hpv gets more people screened! Shockin...

21 Marras 201927min

107. Placebo, Opioid Prescribing, Cancer Screening

107. Placebo, Opioid Prescribing, Cancer Screening

https://insights.ovid.com/crossref?an=00006396-900000000-98602https://jamanetwork.com/journals/jama/article-abstract/2751887?guestAccessKey=8fa2f772-1ba4-40ff-9015-4fcb46d6829e&utm_source=silverchair&...

13 Marras 201927min

106. Kidney disease, Renal outcomes, Hepatitis C, HPV

106. Kidney disease, Renal outcomes, Hepatitis C, HPV

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2748452    -- come one come all unless you are a kidney https://www.ncbi.nlm.nih.gov/pubmed/31054907   SURPRISE!! Women prefer to do s...

6 Marras 201922min

105. Diabetes, Boxer Fracture, ACOG and contraception

105. Diabetes, Boxer Fracture, ACOG and contraception

https://www.ncbi.nlm.nih.gov/pubmed/30347032  Terbinafine adverse effects are rarehttps://www.ncbi.nlm.nih.gov/pubmed/31189511 Dulaglutide prevents MACE but at a high price taghttps://www.ncbi.nlm.nih...

11 Loka 201932min

104. Coronary Artery Calcium Score (CAC) - Should You Count On it?

104. Coronary Artery Calcium Score (CAC) - Should You Count On it?

Let's look at the numbers behind CAC! The best evidence is found here https://jamanetwork.com/journals/jama/fullarticle/2687224 but the largest study is found here https://www.sciencedirect.com/scienc...

18 Syys 201923min

103. Evidence Based Guidelines? When Do You Test Cholesterol?

103. Evidence Based Guidelines? When Do You Test Cholesterol?

https://www.ncbi.nlm.nih.gov/pubmed/30874755 - ACC/AHA and ESC are still not evidence basedhttp://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.939.1670&rep=rep1&type=pdf -- only need to check e...

6 Syys 201920min

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