Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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102. DOAC and hematuria  plus a listener question

102. DOAC and hematuria plus a listener question

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2739056 not all guidelines are equal, think for yourself. Some guidelines even do harm when you actually look at the evidence. h...

2 Syys 201928min

101. 3A- Aspirin, Asthma, AntiPlatelet

101. 3A- Aspirin, Asthma, AntiPlatelet

https://www.nejm.org/doi/full/10.1056/NEJMoa1813959 even when we dont know where the stroke is coming from- aspirin is still king all these years later https://www.thelancet.com/journals/lancet/artic...

13 Elo 201921min

100. 3H episode= Hakuna Matata, HIV, and HPV

100. 3H episode= Hakuna Matata, HIV, and HPV

https://www.cdc.gov/mmwr/volumes/68/wr/mm6825a2.htm we are not testing people for HIV even though guidelines https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/human-im...

2 Elo 201925min

Got 99 (episodes) and an IMPORTANT Article Before It's Done

Got 99 (episodes) and an IMPORTANT Article Before It's Done

https://www.ncbi.nlm.nih.gov/pubmed/30608562 A1C level low is not good and high is not good cause both seem to wind up have you the pt. in the hospital for hypoglycemia- the low point of the U curve ...

24 Heinä 201918min

98. A New Drug, Sugar Legacy, Statin in the Elderly

98. A New Drug, Sugar Legacy, Statin in the Elderly

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31942-1/fulltext If you are over 70 or 75 and primary prevention then likely no benefit in statins and secondary benefit is very sm...

12 Heinä 201922min

97. Old Women Walking, Energy Drinks, and Antibiotics

97. Old Women Walking, Energy Drinks, and Antibiotics

https://www.ahajournals.org/doi/10.1161/JAHA.118.011318 energy drinks prolong the QT just ever so slightly in healthy 22yr olds so if you are thinking of telling grandma to slam 32ounces of energy d...

27 Kesä 201925min

96. Sprinting to Induction of Clopidogrel

96. Sprinting to Induction of Clopidogrel

vitamin d- if you cant give up on it then give up on checking the lab value- fire and forget. https://www.nejm.org/doi/full/10.1056/NEJMoa1800566 induction at 39 weeks is okay with me https://jamane...

14 Kesä 201926min

94. New Afib Guidelines, New standard for SK, and Foley cath + UTI

94. New Afib Guidelines, New standard for SK, and Foley cath + UTI

afib- new guidelines! https://www.google.com/search?q=2019+American+Heart+Association%2C+American+College+of+Cardiology+and+the+American+Rhythm+Society+focused+update+from+their+2014+guidelines+for+...

21 Touko 201925min

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