Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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93. Breakfast, Tramadol, and Knee Osteoarthritis

93. Breakfast, Tramadol, and Knee Osteoarthritis

https://www.bmj.com/content/364/bmj.l42 skip breakfast- it doesn't help you 'lose weight' https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2723074 Automated BP cuffs are the...

9 Touko 201925min

92. Sports Medicine, Vitamin D, Shared Decision making and Chronic Pain

92. Sports Medicine, Vitamin D, Shared Decision making and Chronic Pain

shared decision making for lung cancer rarely happens in the community and when it does happen 2/5 said no thanks to cancer screeninghttps://jamanetwork.com/journals/jamainternalmedicine/article-abstr...

23 Huhti 201920min

91. Statins, Oxycodone, Smart Phones, Weight Loss, and Antibiotics

91. Statins, Oxycodone, Smart Phones, Weight Loss, and Antibiotics

https://www.emrap.org/episode/rightonprime/introduction RIGHT ON PRIME IF YOU NEED CME 10% likely isn't high risk but it certainly deserves more than 0.6% of people on statins so don't forget your sta...

17 Huhti 201927min

90. HPV, Push-ups, HIV, E-Cigarettes, Expiration Dates

90. HPV, Push-ups, HIV, E-Cigarettes, Expiration Dates

https://www.emrap.org/episode/rightonprime/introduction RIGHT ON PRIME IF YOU NEED CME https://www.bmj.com/content/364/bmj.l240 hpv is still bosshttps://jamanetwork.com/journals/jamanetworkopen/fulla...

30 Maalis 201925min

89. Parkinson's, BNP, RIGHT ON PRIME!!

89. Parkinson's, BNP, RIGHT ON PRIME!!

https://www.emrap.org/rop?episode-guide-publish-date=%5B568011600000%2C1552613520000%5Dhttps://www.nejm.org/doi/full/10.1056/NEJMoa1809983?query=featured_home parkinsons and symptoms- start levadopaht...

15 Maalis 201922min

88. 3A's = Antibiotics, Aspirin, Anemia

88. 3A's = Antibiotics, Aspirin, Anemia

https://annals.org/aim/article-abstract/2719218/long-term-outcomes-among-patients-discharged-from-hospital-moderate-anemia#an_fo_ho Anemia is not being fixed 6months after hospitalization but tha...

24 Helmi 201922min

87. HPV, Self Swab, Intermittent Fasting and More

87. HPV, Self Swab, Intermittent Fasting and More

https://www.bmj.com/content/363/bmj.k4823 self swabs workhttps://onlinelibrary.wiley.com/doi/full/10.1002/oby.22345 intermittent fastinghttps://jamanetwork.com/journals/jama/article-abstract/2718066 V...

17 Helmi 201923min

86. Top Articles of 2018 part 3

86. Top Articles of 2018 part 3

My view of some of the top articles and medical headlines from 2018.

10 Helmi 201919min

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