Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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85. Part 2- More Articles From 2018

85. Part 2- More Articles From 2018

Mechanical thrombectomy, FDA and concussion. HPV vaccine and more on this episodes covering top articles from 2018.

3 Helmi 201920min

84. Top Articles of 2018

84. Top Articles of 2018

1 of many in which I break down what I think are articles or titles of 2018 you need to know about (hint: my have been discussed on QM before)

24 Tammi 201924min

Repost 82. Mammograms and Breast Cancer Screening Part 2

Repost 82. Mammograms and Breast Cancer Screening Part 2

This is a heated debate but the numbers tell the whole story. So let's dig into the numbers a little more and find the real benefit of the screening mammogram.

6 Marras 201822min

81. Mammograms, Pink Ribbons, and Screening part 1

81. Mammograms, Pink Ribbons, and Screening part 1

It is time to tackle screening mammograms. I warn you, this is evidence, try not to listen with emotion.

24 Loka 20184min

80. Articles and What to do with Statins, CRP, and Calcium Score

80. Articles and What to do with Statins, CRP, and Calcium Score

Heading to FMX and the bags are packed!! Here is a little something to hold you down till I return! If you are going to be there then tweet me @andrewbuelt

8 Loka 201838min

78. Hep C and ESRD along with so much more

78. Hep C and ESRD along with so much more

Another hard hitting Questioning Medicine packed with all sorts of articles and gems. Times are changing for those that have to sit in a chair 3 days a week and it is coming from those with hep. C

15 Syys 201828min

76. Alcohol sniffer with my Aspirin, please!

76. Alcohol sniffer with my Aspirin, please!

Two big articles in this episode that have already changed my practice and I tell you how. Plus, a bunch of other articles I think people should be talking about! What is the real risk for statins? Wh...

23 Elo 201827min

75. Sun Protection, Prostate and Atrial Fib Screening?

75. Sun Protection, Prostate and Atrial Fib Screening?

Another episode with lots of articles- What is the UVB protection on SPF. Atrial fib screening, should we do it? What IUD makes you not gain weight? One article on Fake news on babies sleeping and a n...

12 Elo 201826min

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