Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

https://pubmed.ncbi.nlm.nih.gov/38598573/

In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptomatic COVID-19, does paxlovid--nirmatrelvir-ritonavir reduce the duration of symptoms or the likelihood of hospitalization?

Nirmatrelvir-ritonavir (Paxlovid) was shown in its initial randomized trial to reduce hospitalization and death in unvaccinated adults with at least one risk factor for severe disease when the ancestral variant of SARS-CoV-2 was predominant.

But it is important that drugs be evaluated in the correct target population patients who have been vaccinated or have the Omicron variant.

This industry-sponsored study enrolled 2 groups of patients: (1) fully vaccinated adults with symptomatic, confirmed infection with SARS-CoV-2 and at least one risk factor for severe disease,

(2) unvaccinated adults with a symptomatic infection but no risk factors

The onset of symptoms was within the past 5 days. Patients (N = 1296) were randomized to receive the standard 5-day course of nirmatrelvir-ritonavir or matching placebo.

the 1440 participants who were initially randomized There was no difference in duration of symptoms between groups, and no significant difference in the likelihood of hospitalization or death (0.8% vs 1.6% for placebo; difference -0.8%; 95% CI -2.0 to 0.4).

Jaksot(385)

15. Clinical Testing

15. Clinical Testing

An overview of a few studies and information regarding inpatient and outpatient testing. "The first principle of solid wisdom is discretion.." --Norman MacDonald. A little discussion on understanding ...

21 Loka 201432min

14. IV Fluids part 2

14. IV Fluids part 2

Bottoms up on the last discussion on fluids and a review of a few of the trials that contribute to the current mindset in EBM. Andrew creates his own "Mike Tyson Theory of fluids" and Joe subscribes t...

3 Loka 201424min

13. IV Fluids part 1

13. IV Fluids part 1

A quick discussion one the topic of which patient to give which fluid. Review of studies from the 90s to 2014 with demographics including pre/post Operative, Septic patient and even Rattus Rattus. (th...

25 Syys 201423min

12. Dexa Scan Part 2

12. Dexa Scan Part 2

Hard topic and difficult discussion continues about reasonable intervention and evaluation of therapy for osteoporosis. Andrew starts right off with his personal recommendation on the screening of low...

10 Syys 20147min

11. The Dexa Scam

11. The Dexa Scam

Hard hitting discussion on the evidence on soft bones and the best screening and treatment options. This episode was broken into two parts because Joe needed to run a full NIH Stroke Scale on Andrew m...

1 Syys 201429min

10. Vitamin D Part 2

10. Vitamin D Part 2

Who and when to test. Dose and frequency along with route of administration of Vitamin D are discussed along with 12 studies of outcomes and complications/benefits of each. Joe discovers Andrew is bel...

13 Elo 201431min

8. Watch Were You Are Putting Your Hands...

8. Watch Were You Are Putting Your Hands...

You might be outside the guidelines soon. Joe and Andrew discuss the newest recommendations from ACP regarding bimanual/pelvic exams. Andrew can't hold it any longer and breaks into song for the first...

6 Heinä 201434min

7. Diabetes. It's Not Over Until the Intervals Are Over.

7. Diabetes. It's Not Over Until the Intervals Are Over.

Don't celebrate just yet, the confidence intervals aren't all the way over the line. Andrew gives yet another history lesson on the improvements in Diabetes and runs over some of the recent talk abou...

23 Kesä 201430min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
tiedenaiset-podcast
psykopodiaa-podcast
voi-hyvin-meditaatiot-2
rss-pitaisko-erota
vakeva-elama-viisaampi-mieli-vahvempi-keho
rss-narsisti
rss-kuumilla-aalloilla
meditaatiot-suomeksi
rss-pt-paahtio
selviytyjat-tarinoita-elamasta
rss-nautinto
rss-vapaudu-voimaasi
junnut-pelissa
rss-uplevel-by-sonja-hannus
terapiassa
rss-mighty-finland-podcast
puhu-muru
rss-adama-mindful-hetki
rss-en-saa-unta