The Dr. Geo Prostate Podcast9 Maalis 2025

Can a pill increase Testosterone? with Shalin Shah

In this episode, Dr. Geo Espinosa speaks with Shalin Shah, CEO of Marius Pharmaceuticals, about the latest advancements in testosterone replacement therapy (TRT) and the first FDA-approved oral testosterone pill, Kyzatrex. They discuss the challenges of traditional testosterone treatments, the role of SHBG and free testosterone, and how oral testosterone therapy is changing the landscape of hormone optimization.

Shalin also shares insights on the impact of testosterone on cardiovascular health, the potential of TRT in preventing muscle loss in those using GLP-1 agonists (Ozempic, Mounjaro), and the importance of strength training for hormonal balance and longevity.

Key Topics:

• How oral testosterone therapy works and why previous versions failed

• The role of SHBG, free testosterone, and hormone optimization

• TRT vs. injections vs. gels—what’s most effective?

• Testosterone’s link to cardiovascular health and FDA concerns

• The connection between GLP-1 medications and muscle loss

• Why strength training is critical for hormonal balance

Resources & Links:

Learn More About Kyzatrex: www.kyzatrex.com

Understanding Testosterone & SHBG: www.rethinktestosterone.com

Follow Shalin Shah: @TheMetabolicCEO

Dr. Geo’s Website & Newsletter: www.drgeo.com

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Thank you to our partners

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Improve your urological health with Dr. Geo’s formulated supplement lines:XY Wellness for Prostate cancer lifestyle and nutrition: Mr. Happy Nutraceutical Supplements for prostate health and male optimal living.

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DISCLAIMER: This audio is educational and does not constitute medical advice. This audio's content is my opinion and not that of my employer(s) or any affiliated company.

Use of this information is at your own risk. Geovanni Espinosa, N.D., will not assume any liability for any direct or indirect losses or damages that may result from the use of the information contained in this video, including but not limited to economic loss, injury, illness, or death.

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