#080: B-Cell Depletion – Ocrelizumab (Ocrevus), Ofatumumab (Kesimpta, Bonspri), Rituximab (Mabthera, Rituxan), Ublituximab (Briumvi) for active RRMS and SPMS, and early PPMS

#080: B-Cell Depletion – Ocrelizumab (Ocrevus), Ofatumumab (Kesimpta, Bonspri), Rituximab (Mabthera, Rituxan), Ublituximab (Briumvi) for active RRMS and SPMS, and early PPMS

Learn more about b-cell depletion, including Ocrevus, Kesimpta, Bonspri, Mabthera, Rituxan, and Briumvi, used for active RRMS, SPMS, and PPMS.

You can read the full article on my blog: https://ms-perspektive.com/080-b-cell-depletion

B-cell depletion therapies such as ocrelizumab (Ocrevus), ofatumumab (Kesimpta, Bonspri), rituximab (Mabthera, Rituxan) and ublituximab (Briumvi) have become important tools in the treatment of multiple sclerosis (MS). These treatments specifically target and deplete B cells, a type of immune cell involved in the inflammatory process of MS. B-cell therapies are considered to be some of the most specific and potent disease-modifying therapies (DMTs) available today, offering a tailored approach to reducing disease activity and progression. In this blog, we will explore how these therapies are classified within MS treatment options and what their approval status and efficacy mean for different patient populations.

Please remember that I can only provide an overview here. Your neurologist and your MS nurse should advise you in detail on the right therapy for you. This is because they know your general state of health and you should also talk about your goals, wishes, fears and preferences so that these can be taken into account.

You may also want to look at the posts on the other DMTs:

See you soon and try to make the best out of your life,
Nele

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#173: Immunoadsorption for MS Relapses. Interview with senior physician Anna-Katharina Eser

#173: Immunoadsorption for MS Relapses. Interview with senior physician Anna-Katharina Eser

In this episode, I speak with Anna-Katharina Eser, senior physician at the MS Centre in Mainkofen, Germany, about immunoadsorption in multiple sclerosis. Immunoadsorption is a specialized blood purifi...

1 Heinä 15min

#172: AI for MS. How the CLAIMS Project Could Transform MS Care – with Prof. Friedemann Paul

#172: AI for MS. How the CLAIMS Project Could Transform MS Care – with Prof. Friedemann Paul

In this episode, Prof. Friedemann Paul from Charité – Universitätsmedizin Berlin, Germany, explains how the European CLAIMS project aims to improve multiple sclerosis care through AI-assisted decision...

24 Kesä 35min

#171: The Gut-Brain Axis in Multiple Sclerosis. Interview with Prof. Dr. Anne-Katrin Pröbstel

#171: The Gut-Brain Axis in Multiple Sclerosis. Interview with Prof. Dr. Anne-Katrin Pröbstel

The gut–brain axis in multiple sclerosis is an exciting field of research that connects the gut microbiome, immune system and central nervous system. In this interview, Prof. Dr. Anne-Katrin Pröbstel ...

17 Kesä 19min

#170: Vaccinations and MS – What You Need to Know with Dr. Thomas Grüter

#170: Vaccinations and MS – What You Need to Know with Dr. Thomas Grüter

In this episode, Nele talks with neurologist Dr. Thomas Grüter about vaccinations and multiple sclerosis. The original interview was published in German in December 2024. This English version has been...

10 Kesä 15min

#169: Multiple Sclerosis in Nepal. Diagnosis, Treatment and Access to Care

#169: Multiple Sclerosis in Nepal. Diagnosis, Treatment and Access to Care

In this episode, Nele speaks with Dr. Ayush Chandra and Dr. Avinash Chandra about multiple sclerosis in Nepal. They explain why MS is still often diagnosed late, how limited access to MRI, neurologist...

3 Kesä 58min

#168: From Fragmented Care to Connected Care: The MS360° Approach with Dr. Isabel Voigt

#168: From Fragmented Care to Connected Care: The MS360° Approach with Dr. Isabel Voigt

In this episode, Dr. Isabel Voigt from the MS Center Dresden introduces the MS360° approach, a digital-first hybrid care model designed to make multiple sclerosis care more continuous, proactive, and ...

27 Touko 33min

#167: Living with MS: Fatigue, Walking & Energy — Insights from Sanam

#167: Living with MS: Fatigue, Walking & Energy — Insights from Sanam

In episode #167, Sanam Saeedi shares her perspective on living with MS, fatigue, walking and energy. Diagnosed in 2019, she explains how symptoms such as foot drop, balance issues and fatigue changed ...

20 Touko 28min

#166: Unseen MS Symptoms: A Patient Expert's Perspective from Iceland with Hjördís Ýrr Skúladóttir

#166: Unseen MS Symptoms: A Patient Expert's Perspective from Iceland with Hjördís Ýrr Skúladóttir

What are unseen MS symptoms really like? In this inspiring episode, Hjördís Ýrr Skúladóttir from Iceland shares her personal journey with multiple sclerosis, from diagnosis and burnout to becoming a p...

13 Touko 48min

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