Pearls & Perspectives: Urology's role in GLP-1 RA treatments, with Hossein Sadeghi-Nejad, MD, and Nathalie Eid, BA

Pearls & Perspectives: Urology's role in GLP-1 RA treatments, with Hossein Sadeghi-Nejad, MD, and Nathalie Eid, BA

In this 2-part episode of Pearls and Perspectives from the American Urological Association's (AUA) 2025 Annual Meeting in Las Vegas, NV, host Amy Pearlman, MD, speaks with Hossein Sadeghi-Nejad, MD, director of Men’s Health at NYU Langone, followed by an inspiring conversation with rising medical student researcher Nathalie Eid, BA, to explore the emerging impact of GLP-1 receptor agonists on testosterone levels and men’s health.

Sadeghi-Nejad shares clinical and research insights into how the widespread use of GLP-1 medications is reshaping the management of male patients, especially those struggling with obesity, infertility, and low testosterone. He explains the potential mechanisms behind GLP-1-induced hormonal changes, noting that some testosterone improvements appear independent of weight loss—a discovery that could redefine approaches to metabolic and reproductive health. Sadeghi-Nejad emphasizes the importance of cross-specialty collaboration and ongoing patient education around nutrition, strength training, and sarcopenia risk while using these therapies.

In the second half of the episode, Pearlman sits down with Nathalie Eid, a third-year medical student at NYU who recently presented her research at AUA 2025. Eid’s study, conducted in collaboration with Sadeghi-Nejad’s team, examines the relationship between GLP-1 therapy, testosterone levels, and sexual function. Their findings suggest that GLP-1 medications may directly influence hormonal pathways beyond simple weight loss effects, offering a potential new layer of complexity for clinicians managing hypogonadism in patients already undergoing metabolic treatment.

Together, Pearlman, Sadeghi-Nejad, and Eid highlight how urologists must adapt to a new clinical reality where GLP-1 therapies are common—and where their effects extend beyond glucose control and weight management. The episode reinforces the need for closer monitoring of testosterone levels, rethinking lab protocols, and considering how adjunctive therapies like testosterone replacement may need to be tailored when GLP-1 use is in play.

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Jaksot(215)

The Expert APProach: Advancing APP Leadership and Expertise in Urology, With Susanne Quallich, PhD, ANP-BC, NP-C

The Expert APProach: Advancing APP Leadership and Expertise in Urology, With Susanne Quallich, PhD, ANP-BC, NP-C

Susanne Quallich, PhD, ANP-BC, NP-C, discusses APP leadership, specialization, professional growth, and expanding the role of APPs in urology.

20 Elo 28min

Pearls & Perspectives: Patient Expectations, Physician Autonomy, and Life Beyond Surgery, With Andrew T. Cohen, MD, FACS

Pearls & Perspectives: Patient Expectations, Physician Autonomy, and Life Beyond Surgery, With Andrew T. Cohen, MD, FACS

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, and plastic surgeon Andrew T. Cohen, MD, FACS, discuss managing patient expectations and the importance of cultivating balance outside ...

12 Elo 39min

The UroOnc Minute: Navigating BCG Maintenance Therapy in NMIBC, With Mark D. Tyson, II, MD, MPH

The UroOnc Minute: Navigating BCG Maintenance Therapy in NMIBC, With Mark D. Tyson, II, MD, MPH

In this episode of The UroOnc Minute, Mark D. Tyson, II, MD, MPH, joins host Adam Weiner, MD, to discuss the importance of BCG maintenance therapy in NMIBC and share strategies for navigating treatmen...

12 Elo 13min

Pearls & Perspectives: Wearable Technology and the Future of Sexual Health, With Elliot Justin, MD

Pearls & Perspectives: Wearable Technology and the Future of Sexual Health, With Elliot Justin, MD

Host Amy Pearlman, MD, and guests Larry Lipshultz, MD, and Elliot Justin, MD, explore the potential of wearable technology to advance the diagnosis, monitoring, and optimization of sexual health for b...

12 Elo 15min

Pearls & Perspectives: From Prostate Cancer Diagnosis to Patient Advocacy, with Gabe Canales

Pearls & Perspectives: From Prostate Cancer Diagnosis to Patient Advocacy, with Gabe Canales

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, is joined by male reproductive specialist Larry Lipshultz, MD, and patient advocate Gabe Canales for a candid conversation about prosta...

12 Elo 15min

The UroOnc Minute: Optimizing Patient Follow-Up in Urologic Oncology, With Jason Hafron, MD

The UroOnc Minute: Optimizing Patient Follow-Up in Urologic Oncology, With Jason Hafron, MD

In this episode of The UroOnc Minute, host Adam Weiner, MD, is joined by Jason Hafron, MD, to discuss how data-driven pathways and patient follow-up systems can improve quality and outcomes in urologi...

24 Heinä 12min

Pearls & Perspectives: Understanding the Long-Term Health Effects of Military Exposures, With Shane Kronstedt, MD

Pearls & Perspectives: Understanding the Long-Term Health Effects of Military Exposures, With Shane Kronstedt, MD

Host Amy Pearlman, MD, and Larry Lipshultz, MD, speak with Shane Kronstedt, MD, about research on the long-term urologic effects of military exposures and how these findings may help improve care for ...

22 Heinä 5min

First Assist: Early Cystectomy in Non–Muscle Invasive Bladder Cancer, with Matvey Tsivian, MD

First Assist: Early Cystectomy in Non–Muscle Invasive Bladder Cancer, with Matvey Tsivian, MD

In this episode of First Assist: GU Oncology Unpacked, host Taylor Goodstein, MD, is joined by Matvey Tsivian, MD, to discuss how patient selection, staging, and quality-of-life considerations influen...

15 Heinä 49min

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