Special Episode: Human African Trypanosomiasis & Drug Development

Special Episode: Human African Trypanosomiasis & Drug Development

Our episode last week ended on a hopeful note, a rare occurrence for this podcast, and it was due in large part to the incredible decline in reported cases of human African trypanosomiasis (HAT) over the past decade. In this bonus episode, we explore one of the major reasons behind this drop in HAT: the new medication fexinidazole, developed through a partnership between the Drugs for Neglected Diseases initiative (DNDi), a non-profit organization dedicated to developing new treatments for neglected diseases and Sanofi, a French healthcare company. We are thrilled to be joined by two researchers from DNDi, Dr. Nathalie Strub-Wourgaft and Dr. Wilfried Mutombo Kalonji, who share their insights into the challenges associated with bringing a medication all the way from its development stage, to testing it in the field, and finally ensuring that access is provided for those who need it most. We also chat about how this treatment works, the impact that COVID-19 has had on screening efforts for sleeping sickness, the lessons learned from fexinidazole’s development, and so much more. Tune in wherever you get your podcasts! And when you’re finished with the ep, check out this beautiful video from DNDi chronicling the story of fexinidazole: A doctor’s dream: A pill for sleeping sickness.

See omnystudio.com/listener for privacy information.

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Ep 214 Boogers: Digging for treasure

Ep 214 Boogers: Digging for treasure

Hard and crusty. Green and gloopy. Clear and watery. Boogers come in a veritable rainbow of colors and a full spectrum of textures from liquid to solid. They’re really quite impressive if you think ab...

30 Kesä 1h 2min

Special Episode: Dr. Carl Elliott & The Occasional Human Sacrifice

Special Episode: Dr. Carl Elliott & The Occasional Human Sacrifice

Stories of unethical medical experimentation often center around the individuals who spearheaded such atrocities or highlight how patient protection laws were changed in response to the studies. But r...

23 Kesä 57min

Ep 213 Burns Part 2: It’s like sci-fi but real 

Ep 213 Burns Part 2: It’s like sci-fi but real 

At the turn of the 20th century, a severe burn was often a death sentence. Today, that is no longer the case. Over the past eighty years, burn care has undergone a profound transformation thanks to cr...

16 Kesä 58min

Ep 212 Burns Part 1: The first million or so years

Ep 212 Burns Part 1: The first million or so years

Burns have been a part of the human experience since our hominin relatives began controlling fire 1.5 million years ago. Until very recently, we’ve been limited in our ability to manage burn wounds wi...

9 Kesä 55min

Special Episode: Alexandra Sifferlin & The Elusive Body

Special Episode: Alexandra Sifferlin & The Elusive Body

An accurate diagnosis can give us so much. It can give us a path forward. It can give us answers to long-standing questions. And it can give us much-needed hope. Yet many people around the world wait ...

2 Kesä 51min

Ep 211 Motion Sickness: It comes in waves

Ep 211 Motion Sickness: It comes in waves

It comes on sneakily. You become aware of your stomach. You break out in a cold sweat. Your mouth fills with saliva. And before you know it, you’re leaning over the side of the boat (or out of the car...

26 Touko 1h 16min

Ep 210 Histoplasmosis: Bats, birds, and budding yeast

Ep 210 Histoplasmosis: Bats, birds, and budding yeast

Once thought to be a rare, always fatal disease, histoplasmosis is now recognized as one of the most prevalent fungal infections in North America. It infects hundreds of thousands of people every year...

19 Touko 1h 18min

Special Episode: Dr. Olivia Weisser & The Dreaded Pox

Special Episode: Dr. Olivia Weisser & The Dreaded Pox

In a time when smallpox, tuberculosis, measles, and typhus ran rampant through the streets of London, there was another disease that instilled even more fear than these other killers: syphilis. So fea...

12 Touko 51min

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