Special Episode: Human African Trypanosomiasis & Drug Development

Special Episode: Human African Trypanosomiasis & Drug Development

Our episode last week ended on a hopeful note, a rare occurrence for this podcast, and it was due in large part to the incredible decline in reported cases of human African trypanosomiasis (HAT) over the past decade. In this bonus episode, we explore one of the major reasons behind this drop in HAT: the new medication fexinidazole, developed through a partnership between the Drugs for Neglected Diseases initiative (DNDi), a non-profit organization dedicated to developing new treatments for neglected diseases and Sanofi, a French healthcare company. We are thrilled to be joined by two researchers from DNDi, Dr. Nathalie Strub-Wourgaft and Dr. Wilfried Mutombo Kalonji, who share their insights into the challenges associated with bringing a medication all the way from its development stage, to testing it in the field, and finally ensuring that access is provided for those who need it most. We also chat about how this treatment works, the impact that COVID-19 has had on screening efforts for sleeping sickness, the lessons learned from fexinidazole’s development, and so much more. Tune in wherever you get your podcasts! And when you’re finished with the ep, check out this beautiful video from DNDi chronicling the story of fexinidazole: A doctor’s dream: A pill for sleeping sickness.

See omnystudio.com/listener for privacy information.

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Ep 200 Poop Part 1: How the sausage gets made

Ep 200 Poop Part 1: How the sausage gets made

It might be stinky and it might be unpleasant to behold, but we all do it. For many of us, our poop is out of sight, out of mind once we flush it away. But for the next hour and fifteen minutes or so,...

10 Helmi 1h 11min

Special Episode: Nicola Twilley & Frostbite

Special Episode: Nicola Twilley & Frostbite

For much of the world, refrigeration is such a commonplace technology that we rarely stop to wonder at the many ways it has transformed our lives. From the foods we grow to where we grow them, from ho...

3 Helmi 1h

Ep 199 Sleep Part 2: Predictably unpredictable

Ep 199 Sleep Part 2: Predictably unpredictable

Now that we know just how critical sleep is, we’re all making sure we get the amount we need, right? Unfortunately no. One-third to one-half of Americans are not getting enough sleep, according to pub...

27 Tammi 1h 10min

Ep 198 Sleep Part 1: Sleeping with one eye open

Ep 198 Sleep Part 1: Sleeping with one eye open

Sleep is a universal experience. It’s not just the lion that sleeps tonight - it’s also the butterfly, the chicken, the jellyfish, the dog, the snake, the worm, and of course the human. What is this w...

20 Tammi 1h 14min

Special Episode: Daniel Stone & American Poison

Special Episode: Daniel Stone & American Poison

The widespread use of leaded gasoline in the 20th century led to one of the world’s biggest public health and environmental disasters, the effects of which are still present today. Since its developme...

13 Tammi 57min

Ep 197 Detox: Enemas for everyone

Ep 197 Detox: Enemas for everyone

Ah, the new year. After the last month and a half of indulgent food and drink, disrupted schedules, and laying around the house, who doesn’t feel like they’re in need of a whole-body cleanse? There ar...

6 Tammi 1h 16min

From the Vault - Endometriosis: Menstrual Backwash (Ep 88)

From the Vault - Endometriosis: Menstrual Backwash (Ep 88)

This episode originally aired on January 11th, 2022. Chances are you know someone with endometriosis, or perhaps you’re affected yourself. But despite its incredibly high prevalence, endo remains almo...

30 Joulu 20252h 11min

From the Vault - Hepatitis B: Hepatiti, Take 2 (Ep 89)

From the Vault - Hepatitis B: Hepatiti, Take 2 (Ep 89)

This episode originally aired on January 25th, 2022. In light of the recent changes by RFK jr’s Advisory Committee on Immunization Practices (ACIP) to eliminate the universal birth dose of the hepatit...

23 Joulu 20251h 30min

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