Special Episode: Human African Trypanosomiasis & Drug Development

Special Episode: Human African Trypanosomiasis & Drug Development

Our episode last week ended on a hopeful note, a rare occurrence for this podcast, and it was due in large part to the incredible decline in reported cases of human African trypanosomiasis (HAT) over the past decade. In this bonus episode, we explore one of the major reasons behind this drop in HAT: the new medication fexinidazole, developed through a partnership between the Drugs for Neglected Diseases initiative (DNDi), a non-profit organization dedicated to developing new treatments for neglected diseases and Sanofi, a French healthcare company. We are thrilled to be joined by two researchers from DNDi, Dr. Nathalie Strub-Wourgaft and Dr. Wilfried Mutombo Kalonji, who share their insights into the challenges associated with bringing a medication all the way from its development stage, to testing it in the field, and finally ensuring that access is provided for those who need it most. We also chat about how this treatment works, the impact that COVID-19 has had on screening efforts for sleeping sickness, the lessons learned from fexinidazole’s development, and so much more. Tune in wherever you get your podcasts! And when you’re finished with the ep, check out this beautiful video from DNDi chronicling the story of fexinidazole: A doctor’s dream: A pill for sleeping sickness.

See omnystudio.com/listener for privacy information.

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Ep 191 Famine: More than starvation

Ep 191 Famine: More than starvation

As we learned last week, starvation extends far beyond hunger and what a lack of food does to the human body. Similarly, famine is much more than a food shortage and starvation on a population-level s...

21 Loka 20251h 10min

Ep 190 Starvation: More than hunger

Ep 190 Starvation: More than hunger

Deprived of food, our bodies do the best they can to keep us alive and functioning as long as possible. As the days pass, the rhythms of our lives change: our metabolism, our heartbeats, our hormones,...

14 Loka 20251h 4min

Special Episode: Antonia Hylton & Madness

Special Episode: Antonia Hylton & Madness

The United States is in the midst of a monumental mental health crisis, with one in four people predicted to experience mental illness at some point in their lives. Adequate mental health care remains...

7 Loka 202556min

Ep 189 Newborn screening: The future is here

Ep 189 Newborn screening: The future is here

Every year, millions of babies around the world are screened for dozens of treatable conditions within the first day or two of life. What it takes is a few drops of blood on some filter paper, and wha...

30 Syys 20251h 18min

Ep 188 Candida yeast: Here, there, and everywhere

Ep 188 Candida yeast: Here, there, and everywhere

None of us are ever truly alone. Our bodies are home to untold numbers of microbes, chilling on our skin, in our guts, throughout our respiratory tract, inside our bellybuttons, under our fingernails,...

23 Syys 20251h 17min

Special Episode: Mary Roach & Replaceable You

Special Episode: Mary Roach & Replaceable You

When your car breaks down or your fridge goes on the fritz, you can order a replacement part and get things back up and running in no time. The same cannot always be said for another intricate machine...

16 Syys 202548min

Ep 187 Hypothermia Part 2: How it helps

Ep 187 Hypothermia Part 2: How it helps

Last week, we took you through all the ways that cold can harm us and the harrowing history of humans perishing at its icy hands. Ending the story there would be skipping over the parts where cold get...

9 Syys 20251h 5min

Ep 186 Hypothermia Part 1: How it hurts

Ep 186 Hypothermia Part 1: How it hurts

For all our wondrous adaptations as a species - our big brains, our capacity for language, our opposable thumbs - we humans are not well-equipped to deal with the cold. Take us out of our insulated dw...

2 Syys 202557min

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