Iron Culture presented by MASS25 Kesä 2025

Ep 333 - Are High-Protein Diets Really Harmless?

In this episode of Iron Culture, Dr. Eric Helms talks about his forthcoming article in the MASS Research Review covering the purported harms of high-protein diets. This isn't your typical oversimplified dunk-fest that readily dismisses concerns about high-protein diets. Instead, Helms reviews a thorough paper that reviews common concerns in detail and assessed their plausibility in an objective manner. The claims include:

Claim 1 – protein reduces lifespan
Claim 2 – protein makes bones weaker
Claim 3 – protein harms kidneys
Claim 4 – protein causes diabetes

After that, Dr. Eric Trexler discusses a recent Instagram thread that pulled him into arguments against his will. The post was about his recent article on ketogenic diets and seed oils – two topics that are always bound to attract some controversy and heated debate. This conversation discusses the strengths and limitations of different types of scientific research and also touches on bias, objectivity, and the process of seeking the truth with an open mind.

Time stamps:
0:00 Intro
3:00 Helms' new article about the purported harms of high-protein diets
19:25 Claim 1 – protein reduces lifespan
27:48 Claim 2 – protein makes bones weaker
43:38 Claim 3 – protein harms kidneys
50:53 Claim 4 – protein causes diabetes
57:22 Trex's social media beefs – keto and seed oils
1:03:40 Types of observational studies
1:08:35 Seeking truth versus defending biases
1:17:32 Limitations versus fatal flaws
1:24:19 Limitations of RCTs (randomized controlled trials)
1:32:23 Wrapping up

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