#22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins

#22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject of lipids. In Part III, Peter and Tom dig into HDL, why "reverse cholesterol transport" is a lot more nuanced than what most of us are taught, lipid transport, apolipoproteins, and more. In addition, this episode highlights the complexity of HDL and a discussion about the CETP inhibitor trials.

We discuss:

  • Reverse cholesterol transport [1:40];
  • Lipid transportation, apolipoproteins, VLDL, IDL, and LDL particles [11:00];
  • Remnant lipoproteins and apoC-III [16:45];
  • Particles having sex: lipid exchange [28:00];
  • Cholesteryl Ester Transfer Protein (CETP) and CETP inhibitors [40:45];
  • 2006 CETP inhibitor trial: torcetrapib (Pfizer) [54:45];
  • 2012 CETP inhibitor trial: dalcetrapib (Hoffmann–La Roche) [56:15];
  • 2017 CETP inhibitor trials: evacetrapib (Eli Lilly) and anacetrapib (Merck) [58:00]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

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Building & Changing Habits | James Clear (#183 rebroadcast)

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#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

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#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a "best" diet, complexities of nutrition science, and practical steps for building a sustainable diet

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#327 - Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Dr. Saum Sutaria is the Chairman and CEO of Tenet Healthcare and a...

2 Joulu 20242h 32min

Optimizing life for maximum fulfillment | Bill Perkins (#237 rebroadcast)

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Bill Perkins is one of the world's most successful hedge fund mana...

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#326 - AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives into the worl...

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