#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also gets into the genetics of obesity, as well as a broader discussion of the causes and effects of obesity, energy expenditure, and metabolism.

We discuss:

  • Rudy's background, interest in obesity, and trying to understand the role and impact of adipose tissue [4:15];
  • Finding the first evidence of leptin by studying obese mice [23:30];
  • Zucker rats, and the push/pull theories of obesity [34:45];
  • A breakthrough in obesity research, and closing in on leptin [45:45];
  • Understanding leptin in humans [1:03:30];
  • What Prader–Willi syndrome teaches us about body weight regulation [1:09:45];
  • Leptin and the broad condition of obesity, metabolic consequences of weight reduction, and Peter's self-experiments [1:18:00];
  • How is appetite being regulated? [1:29:45];
  • Are there epigenetic consequences of being obese? [1:37:00];
  • What makes low-carb diets so effective at obesity reduction? [1:46:15];
  • What did Rudy believe 10 years ago that he no longer believes to be true? [1:55:15];
  • Rudy's dream study of the FTO gene [1:57:15];
  • What the hell does insulin resistance actually mean? [2:08:30]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(433)

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#336 - AMA #68: Fasting, well-balanced diets, alcohol, exercise for busy people, wearables, emotional health, assessing cardiovascular health, and more

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#335 ‒ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

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#334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D.

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#333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Matt Kaeberlein, Richard Miller

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#332 - AMA #67: Microplastics, PFAS, and phthalates: understanding health risks and a framework for minimizing exposure and mitigating risk

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