#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also gets into the genetics of obesity, as well as a broader discussion of the causes and effects of obesity, energy expenditure, and metabolism.

We discuss:

  • Rudy's background, interest in obesity, and trying to understand the role and impact of adipose tissue [4:15];
  • Finding the first evidence of leptin by studying obese mice [23:30];
  • Zucker rats, and the push/pull theories of obesity [34:45];
  • A breakthrough in obesity research, and closing in on leptin [45:45];
  • Understanding leptin in humans [1:03:30];
  • What Prader–Willi syndrome teaches us about body weight regulation [1:09:45];
  • Leptin and the broad condition of obesity, metabolic consequences of weight reduction, and Peter's self-experiments [1:18:00];
  • How is appetite being regulated? [1:29:45];
  • Are there epigenetic consequences of being obese? [1:37:00];
  • What makes low-carb diets so effective at obesity reduction? [1:46:15];
  • What did Rudy believe 10 years ago that he no longer believes to be true? [1:55:15];
  • Rudy's dream study of the FTO gene [1:57:15];
  • What the hell does insulin resistance actually mean? [2:08:30]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

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#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Olav Aleksander Bu is an internationally renowned sports scientist...

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#330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Trenna Sutcliffe is a developmental behavioral pediatrician and th...

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Building & Changing Habits | James Clear (#183 rebroadcast)

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter James Clear is the author of the New York Times bestseller Atomic ...

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#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter tackles a wide range o...

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#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a "best" diet, complexities of nutrition science, and practical steps for building a sustainable diet

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives deep into one...

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#327 - Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Dr. Saum Sutaria is the Chairman and CEO of Tenet Healthcare and a...

2 Joulu 20242h 32min

Optimizing life for maximum fulfillment | Bill Perkins (#237 rebroadcast)

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Bill Perkins is one of the world's most successful hedge fund mana...

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#326 - AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging

#326 - AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives into the worl...

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