Urology Times Podcasts19 Syys 2025

First Assist: The Historical Context of NMIBC, with Kamal S. Pohar, MD

In this episode of First Assist: GU Oncology Unpacked, host Taylor Goodstein, MD, speaks with Kamal Pohar, MD, associate professor in the College of Medicine at The Ohio State University in Columbus, about the evolution of management and surveillance for non–muscle invasive bladder cancer (NMIBC).

Pohar begins by tracing the origins of intravesical therapy. Before BCG became standard, chemotherapy agents delivered directly into the bladder showed modest benefits in reducing recurrence. The pivotal moment came in the 1970s, when autopsy observations linking tuberculosis with lower cancer incidence, coupled with animal studies, laid the groundwork for Morales’s landmark trial introducing BCG for bladder cancer. Early randomized studies quickly confirmed its benefit, transforming the field.

The discussion moves to BCG dosing and maintenance regimens. Interestingly, the 6-week induction course arose from the number of vials available in a package rather than strong biologic rationale, yet it has persisted across therapies. Maintenance protocols were later shaped by cytokine response studies and solidified through SWOG-led trials.

Surveillance strategies, repeat transurethral resection of the bladder tumor for T1 tumors, and the introduction of enhanced cystoscopy techniques such as blue light and narrow band imaging are also reviewed. Pohar notes their proven impact on tumor detection and recurrence, with blue light holding stronger evidence and FDA approval for both OR and office settings.

The episode also covers biomarkers, from traditional cytology—refined by the Paris Consensus—to newer adjuncts like UroVysion FISH, used selectively to adjudicate difficult cases. Risk stratification models (EORTC, CUETO) are examined for their contributions and limitations, particularly in the modern BCG era.

Finally, Pohar addresses perioperative intravesical chemotherapy, the impact of BCG shortages, and exciting frontiers such as recombinant BCG and en bloc resection techniques. He emphasizes that although NMIBC management has come far, clinical trials and technological innovation continue to shape a rapidly evolving field.

Chapters
0:41: The emergence of BCG
9:20: The origin of the 6-week induction cycle
13:06: Understanding the maintenance schedule of cystoscopy
21:41: The advent of hexaminolevulinate
38:18: Risk groups
45:14: Perioperative chemotherapy

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The Expert APProach: Advancing APP Leadership and Expertise in Urology, With Susanne Quallich, PhD, ANP-BC, NP-C

Susanne Quallich, PhD, ANP-BC, NP-C, discusses APP leadership, specialization, professional growth, and expanding the role of APPs in urology.

20 Elo 28min

Pearls & Perspectives: Patient Expectations, Physician Autonomy, and Life Beyond Surgery, With Andrew T. Cohen, MD, FACS

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, and plastic surgeon Andrew T. Cohen, MD, FACS, discuss managing patient expectations and the importance of cultivating balance outside ...

12 Elo 39min

The UroOnc Minute: Navigating BCG Maintenance Therapy in NMIBC, With Mark D. Tyson, II, MD, MPH

In this episode of The UroOnc Minute, Mark D. Tyson, II, MD, MPH, joins host Adam Weiner, MD, to discuss the importance of BCG maintenance therapy in NMIBC and share strategies for navigating treatmen...

12 Elo 13min

Pearls & Perspectives: Wearable Technology and the Future of Sexual Health, With Elliot Justin, MD

Host Amy Pearlman, MD, and guests Larry Lipshultz, MD, and Elliot Justin, MD, explore the potential of wearable technology to advance the diagnosis, monitoring, and optimization of sexual health for b...

12 Elo 15min

Pearls & Perspectives: From Prostate Cancer Diagnosis to Patient Advocacy, with Gabe Canales

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, is joined by male reproductive specialist Larry Lipshultz, MD, and patient advocate Gabe Canales for a candid conversation about prosta...

12 Elo 15min

The UroOnc Minute: Optimizing Patient Follow-Up in Urologic Oncology, With Jason Hafron, MD

In this episode of The UroOnc Minute, host Adam Weiner, MD, is joined by Jason Hafron, MD, to discuss how data-driven pathways and patient follow-up systems can improve quality and outcomes in urologi...

24 Heinä 12min

Pearls & Perspectives: Understanding the Long-Term Health Effects of Military Exposures, With Shane Kronstedt, MD

Host Amy Pearlman, MD, and Larry Lipshultz, MD, speak with Shane Kronstedt, MD, about research on the long-term urologic effects of military exposures and how these findings may help improve care for ...

22 Heinä 5min

First Assist: Early Cystectomy in Non–Muscle Invasive Bladder Cancer, with Matvey Tsivian, MD

In this episode of First Assist: GU Oncology Unpacked, host Taylor Goodstein, MD, is joined by Matvey Tsivian, MD, to discuss how patient selection, staging, and quality-of-life considerations influen...

15 Heinä 49min