Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

  • Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
  • The mitochondria in your cells make energy (ATP)
  • There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
  • Cancer cells ferment - therefore they don't use oxygen
  • Not all cancer cells have genetic mutations, but all cancer cells ferment
  • The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
  • This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
  • The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
  • On the other hand, normal cells use oxygen and very little amounts of glucose
  • This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
  • Have to re-emphasize the fact that the DNA damage comes as a downstream effect
  • Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
  • The oxidative stress also causes damage to the nucleus and the genome
  • The field of cancer research studies effects instead of causes
  • We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
  • This is supported by thousands of experiments and studies
  • Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
  • We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
  • Cancer cells can't use ketones
  • There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
  • Basically nobody he's heard of is treating it this way
  • If it's so clear this is how cancer works, why has this not reached the mainstream?
  • The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
  • Entrenched beliefs continue this. Also funding money is all based around the genetic theory
  • If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
  • Cancer is a result of the industrialization as a society
  • Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
  • Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
  • These are all secondary - the root cause is damage to the respiration
  • Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
  • To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
  • Metabolic therapies need to at least be options for people
  • Problem is doctors aren't aware of them or aren't trained on them
  • Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
  • There's therapeutic weight loss and toxic weight loss
  • Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
  • Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
  • Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
  • ROS damages tissues and is why you age
  • He published the glucose-ketone index calculator
  • People need to realize sweets are a treat once in awhile - not an everyday thing
  • The food industry has played into our ancient desires for sweet
  • Otto Warburg studied cancer in the early 1900s
  • He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
  • Because their mitochondria are defective they can't switch back to oxidative phosphorylation
  • He recently published a paper filling in the gaps from Otto Warburg's work
  • Missing link was the glutamine that cancer cells can also use
  • Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
  • He's developed the press-pulse system in his lab to attack tumors strategically
  • Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
  • He's having trouble getting funding for this for some reason
  • One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
  • People are going to have to participate in the management of their disease and the culture of the diseases has to change
  • Another problem is the high cost of these standard therapies - people have to pay $400k
  • His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
  • If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
  • The wheelchair doesn't cause your legs to not work
  • Needle biopsies are putting people at risk and are pointless
  • He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
  • What do critics of his views say? They try to create doubt
  • They rely on private funding and some great organizations supporting this research
  • Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
  • His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
  • Dr. George Yu's foundation https://yufoundation.org
  • Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
  • Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Jaksot(235)

Part 171 - All my Health Tips/Thoughts in One Place! (Brian Sanders interviewed by Courtney Swan)

Part 171 - All my Health Tips/Thoughts in One Place! (Brian Sanders interviewed by Courtney Swan)

This week I'm posting Courtney Swan interviewing me!   Her site: https://www.realfoodology.com     GET THE MEAT http://NosetoTail.org      Topics Discussed: Pre-diabetes Insulin resistance Food pyramid What we got wrong about red meat Veganism Carnivorism Grains How grains changed the way humans evolved History of processed foods Food marketing Climate change How agriculture kills animals too Energy balance consortium Importance of building muscle Healthy state of some indigenous tribes The Maasai people Seed oils Satiety   GET THE MEAT http://NosetoTail.org    Follow along: http://twitter.com/FoodLiesOrg  http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

5 Loka 20221h 10min

Part 170 - Dr. William Davis on the Simple Diet Switches to Change Your Life & Your Gut Health

Part 170 - Dr. William Davis on the Simple Diet Switches to Change Your Life & Your Gut Health

Dr. William or Bill Davis is a cardiologist, a New York Times #1 bestselling author of the Wheat Belly book series and is the Medical Director and founder of the Undoctored program including the Undoctored Inner Circle, where he helps individuals take back control of their gut, health and lifestyle. Dr. Bill is also the Chief Medical Officer and co-founder of Realize Therapeutics Corp. that is developing innovative solutions for the disrupted human microbiome and author of the book Super Gut GET THE MEAT http://NosetoTail.org SHOW NOTES: [0:25] - Dr. Bill's thoughts on vegetarianism and veganism and the common nutrient deficiencies that accompany the diets [5:00] - Dr. Bill's background, Why he is so outspoken about nutrition and heart health, and the birth of his book Wheat Belly [16:00] - How humans amplified the destructive nature of Grains, Wheat and Soy [28:00] - Modern gut health, measuring microbiota and his book Super Gut [38:05] - Dr. Bill's take on Keto/Carnivore/Low FODMAP diets and their effects on the gut microbiome [45:40] - SIBO, Pre and Probiotics, and creating your own probiotic regiment based on your goals [59:00] - The Hadza, Ancestral diet and Moderns toxins [1:12:20] - Solutions from Dr. Bill to Improve health and your gut GET THE MEAT http://NosetoTail.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

28 Syys 20221h 27min

Part 169 - How to Fight Big Food, the Banking System & Corporate Control w/ Tristan Scott

Part 169 - How to Fight Big Food, the Banking System & Corporate Control w/ Tristan Scott

Embracing nature, loving the land, and teaching how you can embrace regenerative agriculture and cryptocurrency, Tristan Scott, is the author of the recently released Bitcoin and Beef: Criticisms, Similarities, and Why Decentralization Matters.  Both the regenerative agriculture space and the supporters of Bitcoin have many things in common, such as a disdain for large corporations that only seek to maximize profit, a lack of nuance in local problems and solutions, and deception of the masses.  Tristan brings a factual based argument to many of the myths and solutions that are facing the world today.  Bitcoin and Beef, The Book   BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post   SHOW NOTES: [0:20] - Bitcoin & Beef: Why and What? [9:00] - What is Bitcoin and why should you care? [15:30] - What are the downsides to Bitcoin? [21:20] - What is the one thing that could go wrong with Bitcoin? [30:10] - Food systems, global reserves, and food subsidies  [38:45] - The Beef Initiative and the US Beef Market [45:45] - Should we be buying grocery store meat? [53:20] - Can we do this large scale? Stats on Regenerative Agriculture [1:05:50] - Climate, Pollutants and Beef Emissions [1:17:00] - The Bill & Melinda Gates Foundation and African Farming [1:21:40] - 1971 and the getting off the Gold Standard [1:26:00] - How to get involved with your local farmers and get involved in decentralization at an individual level https://www.sovereignhumans.org   BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Elo 20221h 42min

Part 168 - Dr. Anthony Chaffee - Do Humans Thrive Most on an All-Meat Diet?

Part 168 - Dr. Anthony Chaffee - Do Humans Thrive Most on an All-Meat Diet?

Dr Chaffee is an American medical doctor and Neurosurgical resident who, over a span of 20+ years, has researched the optimal nutrition for human performance and health. It is his assertion that most of the so-called chronic diseases we treat as doctors are caused by the food we eat, or don't eat, and can be reversed with dietary changes to a species specific diet. He began University at the age of 15 studying Molecular & Cellular Biology with a Minor in Chemistry at the University of Washington in Seattle, which culminated in an MD from the Royal College of Surgeons. Currently in Australia, he specializes in Neurosurgery and does private consultations in functional medicine while thriving on a carnivore diet https://www.patreon.com/thecarnivorelife GET THE MEAT! http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: [3:00] - Why Dr. Anthony thinks we are built biologically to be carnivores [10:30] - Why humans don't need teeth and claws to thrive [18:15] - Are we made to eat plants? [25:35] - Why most plants are toxic for you [32:20] - Longevity: Can we live to 120? [45:20] - Blue zones and genetic differences in humans [53:00] - Why are so many groups trying to villainize meat [1:14:00] - Fruit: good or bad? [1:23:25] - Thyroid and Sleep issues on carnivore/keto? [1:35:00] - Organ vs. Skeletal meat ancestrally and in modern times [1:38:10] - Grass-fed vs.Grain-finished GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

17 Elo 20221h 55min

Part 167 - Kate Deering on How to Fix Your Metabolism

Part 167 - Kate Deering on How to Fix Your Metabolism

Kate Deering brings 25 years of experience in the holistic health and wellness space, along with a robust and tested approach to healing someone - nutritionally, mentally, physically and spiritually. With a dense background in sports performance, biochemistry, and physiology, Kate has recently shifted her thoughts on what "true-health" meant, focusing on a more root-cause, holistic approach towards optimal health, while also writing the book "How to Heal Your Metabolism" She often is associated with the likes of Ray Peat and Jay Feldman, embracing fruit, sugar and carbs as a natural and fundamental source of energy, focusing on the underlying issues that leads to intolerances in handling carbohydrates. www.katedeering.com Kate's Instagram GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [0:10] - Recap of the discussion between Kate and Jaime Seeman [4:40] - What is the Ray Peat Diet and Bioenergetic philosophy [9:10] - Stress and energy production [15:50] - Why burning fat may be stressful to the body [22:05] -Long-term stress levels and Type 2 Diabetes [33:15] - OMAD and Protein levels and general macro advice [45:15] - Digestion and nutrient bioavailability [51:55] - Cholesterol - does it matter? [54:30] - Stress, The GI system and exercise [59:20] - Blood sugar, hormones and fruit [1:09:37] - What are the most nutrient dense foods? [1:14:28] - The context of different carb types in the bioenergetic philosophy [1:19:40] - Food logging vs "Intuitive Eating", and overeating [1:31:40] - Does this approach make sense ancestrally? GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

10 Elo 20221h 47min

Part 166 - Dave Asprey on How to Navigate the Crazy Modern World

Part 166 - Dave Asprey on How to Navigate the Crazy Modern World

Dave Asprey is the "Father of Biohacking", a 4x New York Times Bestselling Author, the founder of several companies such as Bulletproof and Upgrade Labs, as well the host of the award-winning podcast The Human Upgrade. Dave's mission is to empower the entire globe with information and knowledge that unlocks the Super Human in everyone at any age, working with world-renowned doctors, researchers, scientists, and global mavericks to uncover the latest, most innovative methods, techniques and products for enhancing mental and physical performance. BUY THE MEAT NosetoTail.org SHOW NOTES: [1:20] - Freedom, Rights and Handed-Down Wisdom [10:50] - Consciousness and Food [16:10] - Making Money and Promoting your Brand - Dave's Take [19:30] - How food affects the speed your brain works [24:00] - Conspiracy theories and purposeful lying, and rational action [31:40] - Are CEOs trying to destroy the world or do good? [38:00] - Where should we get fats from? [44:30] - Grass-finished meat, Ancestral Eating and Nutrient Density [53:40] - Plant vs. Animal foods and a dietary framework [1:00:20] - Eat these and stop doing what makes you weak [1:04:20] - The absurdity of "The China Study" and nuance around food [1:08:30] - Dave's thoughts on protein, collagen and digestive enzymes BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

3 Elo 20221h 29min

Part 165 - Jay Feldman on Are You Producing Maximum Energy From Your Diet?

Part 165 - Jay Feldman on Are You Producing Maximum Energy From Your Diet?

Jay Feldman is a health coach, independent health researcher, and host of the Energy Balance podcast. He has degrees in neuroscience and exercise physiology and is devoted to using his knowledge and experience to help people heal from all manner of disease, dysfunction, and difficulty losing excess body fat. To work with Jay you can find him at http://jayfeldmanwellness.com GET THE MEAT http://NosetoTail.org SHOW NOTES: [1:02] - Jay's background and beginnings in nutrition, exercise and health [6:30] - The basis of disease and energy metabolism [9:30] - Insulin resistance, glucose and Jay's stance on low-carb diets [16:30] - Fructose and fatty liver disease [21:05] - Types of carbohydrates, fruit juice and a discussion on glucose spikes [31:20] - Why Jay recommends eating every 3-5 hours [43:35] - General advice for the general population and carbohydrate addictions [52:48] - Overeating, hunger signals why very fat people cannot access their stored energy [53:35] - Gut health and common issues that occur [1:02:00] - Jay's thoughts on paleo and other ancestral diets [1:08:40] - Fat or carbs for fuel? Which is better [1:14:45] - Stress: the good and bad types [1:19:01] - "Why do I need to eat breakfast?" [1:24:56] - Are PUFAs the worst part of the Standard American Diet? [1:31:00] - Is the Bio-Energetic way of eating ancestrally appropriate? GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Heinä 20221h 45min

Part 164 - Farmer Angus on Feeding (and Saving) the World

Part 164 - Farmer Angus on Feeding (and Saving) the World

Big podcast with Farmer Angus who was visiting Austin from Cape Town, South Africa. It was so great to talk in person with someone from halfway around the world who is entirely on the same page. We talk about how good food works, good animal agriculture works, and even how the world works. A great chat with a great guy - don't miss it! GET THE MEAT http://NosetoTail.org SHOW NOTES: [1:45] - The Food Lies Trailer and film update [3:40] - Angus's thoughts on the plant-based narrative and it infiltrating traditional African agriculture [8:45] - Glyphosate and Industrial agriculture [15:03 - What problems and solutions Angus saw visiting farms in the US [20:10] - Angus's thoughts on Weston A Price and his teachings [31:10] - The downward spiral of conventional agriculture and farmers [37:10] - The history and disintegration of Zimbabwe, the "breadbasket" of Africa [41:20] - How we can feed the world [50:30] - Brief overview of Brian's Sapien Compound [55:05] - Fertilizer, methane emissions, and food waste [1:07:42] - The WHY behind Angus's Farm and How they do it GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

20 Heinä 20221h 21min

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