Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

This is an interview I've been looking forward to for years. Dr. Dale Bredesen is shaking up the medical world by showing that Alzheimer's actually can be prevented, treated, and sometimes even reversed. This is really important to me because my mom is the final stages of Alzherimer's and I, of course, am doing everything I can to prevent myself from falling to the same fate.

I believe the Sapien way of eating and lifestyle is doing just that - setting me up for my best chances at my longest healthspan. You can learn more about this at http://sapien.org/diet

Dr. Bredesen and I agree on all the core principles. He really is describing a Sapien diet with his protocol. We're only at odds with the ratio of plant foods to animal foods.

As I've posted today on social media, I think people are actually more on the side of animal foods than they think. In the context of a whole foods, low carb diet without refined grains, sugar or vegetable oil, more often than not people are getting the majority of their calories from animal foods without necessarily realizing it. Only people eating Standard American Diets or Mediterranean Diets and the like are getting most of their calories from plant foods from all the empty calories coming from grains and other carbohydrates.

Many health figures in this space say things like "a plant heavy diet" or "fill half your plate up with greens" and people take this as being akin to a vegetarian diet. As I showed in my post, a daily intake where about 70% of the plates are filled with plants are actually 92% animal foods by calories.

I actually eat this way a lot. This is carnivore adjacent and is part of the Sapien Framework. You're still getting a ton of flavor, variety, and nutrients from plants (even though they're not as bioavailable), but you're really getting 90% of your calories from animal foods. So make your own decision on the ratio of plant to animal foods, but from what I've found, higher animal foods is more species appropriate for homo sapiens, and is actually what most people avoiding empty calorie, nutrient poor foods are already doing.

As always, I didn't want to press him on this. I don't invite people on my podcast to tell them I don't agree with their opinions. I'd love for this to be debated with a moderator at some point, but as long as it's a 1 on 1 Peak Human podcast I'm letting the guest speak their minds.

Here's a bit of Dr. Bredesen's extensive resume. He received his undergraduate degree from Caltech and his medical degree from Duke. He served as Resident and Chief Resident in Neurology at UCSF, he was the Director of the Easton Center for Alzheimer's Disease Research, he's a Professor in the Department of Molecular and Medical Pharmacology at UCLA School of Medicine, and the Founder of the Buck Institute for Research on Aging.

The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process, and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, leading to the publication of over 220 research papers. He and his group developed a new approach to the treatment of Alzheimer's disease, and this approach led to the discovery of subtypes of the disease, followed by the first description of reversal of symptoms in patients with MCI and Alzheimer's disease, with the ReCODE protocol, published in 2014, 2016, and 2018. His book, The End of Alzheimer's, is a New York Times Bestseller and has been translated into 29 languages.

I'll largely skip the plugs for today. Everyone listening knows about the Food Lies film on Indiegogo, the Patreon at http://patreon.com/peakhuman and my new grass fed meat company http://NoseToTail.org If you find any value in this podcast or my other content on YouTube or social media channels, please consider supporting me and my projects there. I wish I could really get across how much it means to me. It's honestly the only way any of this is possible. Thanks so much, and I'll most likely end season 3 with this episode and come back in a couple weeks with an amazing season 4. Here's the future legend, Dr. Dale Bredesen.

BUY THE MEAT NosetoTail.org

Preorder Food Lies: http://indiegogo.com/projects/food-lies-post

Support me on Patreon! http://patreon.com/peakhuman

SHOW NOTES

  • Dr. Bredesen has been studying the phenomenon of Alzheimer's Disease (AD) for 3 decades and have published over 200 papers on his research
  • Understanding the fundamental nature of the disease is how we can design an effective treatment
  • His protocol is different because it targets the root cause, not the symptoms like most AD drugs do
  • Humans are extremely complicated and there is no one single therapy that will treat the complexity of AD
  • AD is the result of the brain protecting itself from different insults
  • The protective response in the brain causes the brain to shrink and "retreat" so that there is less for foreign substances (insults) to target
  • Amyloids are antimicrobial, bind to toxins, and change the brain's response to glucose but when they are overproduced and build up that's when problems occur
  • Some of the contributors to AD are: chronic inflammation, insulin resistance, glycation damage, toxin exposure, decrease in nutrients, hormones, trophic factors, poor vascular support
  • He has identified and categorized 6 different types of AD: inflammatory, atrophic, glycotoxic, toxic, vascular, and traumatic
  • Paraffin candles produce toxins that damage the brain
  • Most damaging mycotoxins (produced from mold) are the ones you breathe - test your home for molds
  • Go to www.survivingmold.com to learn how to test your home for mold and if you are concerned about mold exposure to learn about what to personally get tested
  • For overall markers you should get tested, you can order tests directly from Dr. Bredesen's site www.drbredesen.com or go to your doctor and test markers
  • Markers for glycotoxicity: fasted insulin, HbA1c, and fasted glucose
  • Markers for nutrients, hormones, and trophic factors: o Vit. D, pragnenolone, progesterone, estradiol, testosterone, free T3 and free T4 (for thyroid), TSH (thyroid stimulating hormone), and reverse T3 (which is an inhibitor of the effect of your active thyroid hormone)
  • Inflammation markers: HS-CRP, TNF-a, IL6, IL8, IL1-b
  • Don't wait until it's too late to check for these things, because AD is preventable
  • Glycotoxicity and how sugar is toxic
  • Humans are not designed to eat sugar
  • Overconsumption of sugar is linked to hypertension, CVD, diabetes, dementia, arthritic, leaky gut, and more
  • Sugar is this generation's smoking, we will get to a day when we think back to how crazy it was that we were eating this stuff
  • We have biomarkers that will tell you whether AD is creeping up on you, so check early in life because you might not feel sick now, but that doesn't mean it's not on its way
  • All these lifestyle and diet changes that you make to prevent AD, apply to so many other modern illnesses
  • If AD runs in your family, you should be interested in prevention
  • AD should be a rare disease
  • APOE4 is the most common genetic risk factor
  • If you have a single copy of APOE4 the risk is ~30%
  • If you have a double copy of APOE4 the risk becomes greater than 50%
  • For people with APOE4, find out early and get on prevention, and you will have a low chance of getting the disease
  • 21st century medicine is about root cause and prevention
  • There is no mono-therapy for AD
  • Look out for symptoms of early cognitive decline like the lack of ability to learn new things, losing organizational skills, not being able to do simple calculations, not being able to find the right word, getting lost in familiar places
  • Don't shake these off as "senior moments"
  • Basic things everyone can do: optimize insulin sensitivity, follow a low-carb, moderate protein, high (good) fat diet, exercise, get enough sleep, reduce stressors in your life, detox, avoid or fix any gut issues, go into periods of ketosis
  • His diet plan is called "KetoFlex 12/3"
  • "Keto" for going into periods of ketosis
  • "Flex" because it is flexitarian, if you want to be a vegetarian or eat meat you can do either
  • "12" because he wants people fasting for at least 12 hours between dinner and the next day's first meal
  • "3" because he wants people to finish eating at least 3 hours before they go to sleep
  • The Big Four to avoid: grains, simple carbs, dairy, and lectins
  • He has had amazing success with his patients and has been publishing results since 2014
  • He has never had someone at risk come in for prevention and develop even mild cognitive impairment (MCI)
  • People who come in with subjected cognitive impairment (SCI) see improvement
  • People who come in with MCI the majority improve
  • People with full-blown AD, some people improve and some people don't
  • He has had people score zero on cognitive tests that have improved
  • The most important point of all of this is that if you get put on a drug for AD you might get a little bump but you fall back to declining again, his approach targets what is actually causing the decline, the people who get better sustain their improvement
  • Complexity gap between the complexity of the problem (human illness) and the data sets that traditional medical doctors are using to treat them (aka we can't expect a simple mono-therapy to treat a complex condition)
  • Dr. Bredesen's daughter is a brain health coach and you can find her at www.siabrainhealth.com
  • His protocol includes sauna for riding the body of toxins
  • We are swimming in an Alzheimer's soup with the amount of toxins we are exposed to in our modern world
  • Get rid of toxins by sweating (sauna and exercise), high fiber diet, optimizing glutathione levels, filtered water, urination, each one of these gets rid of different things
  • If you have leaky gut, fix that
  • The importance of sleep
  • Current research on macular degeneration
  • His new book coming out "The First Survivors of Alzheimer's Disease" will be about people's first-hand stories of people told they had no hope but used his protocol and got better and have kept themselves better
  • The future of medicine will need to look at how humans were evolutionarily designed to live
  • You are not powerless to AD, you have control over it
  • We can reduce the global burden of dementia, we can fight cognitive decline
  • Find Dr. Dale Bredesen at www.drbredesen.com
  • His Facebook page https://facebook.com/drdalebredesen/

BUY THE MEAT NosetoTail.org

Support me on Patreon! http://patreon.com/peakhuman

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Jaksot(233)

Part 153 - Dr. Michael Ruscio on All Things Gut Health

Part 153 - Dr. Michael Ruscio on All Things Gut Health

I had a great talk with Dr. Michael Ruscio today on all things gut health! Dr. Ruscio is Doctor of Natural Medicine, Doctor of Chiropractic, clinical researcher and author [1, 2]. His work has been published in peer-reviewed medical journals and he is a committee member of the Naturopathic Board of Gastroenterology research division. His high quality probiotics: https://store.drruscio.com/?rfsn=6444749.3a233de

30 Maalis 20221h 10min

Part 152 - Josh Trent on the 5th Pillar of Health

Part 152 - Josh Trent on the 5th Pillar of Health

I usually talk about the 4 pillars of health which I focus on most - diet, sleep, a form of exercise, and sun/outdoors. Josh has been studying what I'm calling the 5th pillar which is the mind/body/spirit stuff that includes stress, breathing, emotional intelligence, etc. I had a great time recording this with him at his home in Austin. We did an hour in the sauna and a cold plunge afterwards!   Josh Trent is the Founder of Wellness Force Media, host of the Wellness + Wisdom Podcast and the creator of the BREATHE a Breath & Wellness Program.   Josh has spent the past 19+ years as a trainer, researcher, and facilitator discovering the physical and emotional intelligence for humans to thrive in our modern world.   Josh and Wellness Force Media Mission is to help humans heal mental, emotional and physical health through podcasts, programs, and a global community that believes in optimizing our potential to live life well.   Josh has dedicated his life to supporting humanity coming together as one.   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org     SHOW NOTES [1:28] - Josh's Background and journey to Wellness Force  [8:15] - Brian's asks Josh to help us understand the spiritual, mental and emotional side of well-being  [22:00] - The Art, Science and Technique  of Breathwork [35:16] - How Past Trauma and Breathwork are related [44:45] - Tips for better breathing posture  [50:30] - The Beginning, Middle and End of Breathwork [57:00] - Looking at Breathwork through an Ancestral Lense [1:01:10] - Josh and Brian's thought son Psychedelics [1:10:00] - The trap of being uncomfortable in our modern life [1:15:45] - What the BREATHE: Breathe and Wellness program and Why Breathwork is so powerful to Josh   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Maalis 20221h 29min

Part 151 - Dr. Nick Nwabuaze (The Fittest Doc) Practical Strategies to Improve your Health & Body

Part 151 - Dr. Nick Nwabuaze (The Fittest Doc) Practical Strategies to Improve your Health & Body

Dr. Nwabueze is a board-certified Family Medicine physician who focuses on helping his patients fix the root cause of their stress and poor health. He completed medical school at the Ohio State University College of Medicine and finished his internship and residency at Adventist Hinsdale Hospital in Illinois. He currently uses a mix of resistance training, nutrition coaching, and lifestyle management to form long term relationships with his clients, improving their overall health and happiness through Steady MD, using the Direct Primary Care modality. Find him on Instagram and other social media platforms @thefittestdoc GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDEhttp://sapien.org SHOW NOTES [1:45] - Dr. Nick's Background and Beginning [5:52] - Brian and Nick's thoughts on "Movement is Medicine" [10:50] - How Movement plays into Fat Loss [19:45] - How everything that we put our body through (food, exercise, work) is all stress and how we hormetically get stronger and fitter long-term [23:30] - How and why you should measure Body Composition [32:30] - Brian and Nick's Workout Routines [43:25] - Nick's Mindset on Diet and Nutrition [51:25] - How Dr. Nick works though obesity, obese clients, and mainstream views around obesity [1:21:00] - How Dr. Nick practices medicine with SteadyMD and why he loves it Reach Nick here on SteadyMD GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDEhttp://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg http://youtube.com/c/foodlies

4 Maalis 20221h 30min

Part 150 - Richard Perkins on the True Diet of Our Ancestors and Replicating this in Sweden

Part 150 - Richard Perkins on the True Diet of Our Ancestors and Replicating this in Sweden

Richard Perkins is a worldwide leader in the regenerative agriculture space, an author, educator, and farmer. He lives in Sweden with his family on a holistically managed and integrated farm producing a variety of animal and plant foods for his family and community. His practices have taught him how humans must have provided food for themselves for the lion's share of history. From his decades of experience combined with the scientific literature and other accounts around the world, it's apparent they were eating locally & seasonally and relying on nose to tail animal nutrition for the majority of their calories. Please enjoy this episode! GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Maalis 20221h 33min

Part 149 - Chris Masterjohn, PhD on Analyzing the Hidden Data You're Not Hearing About

Part 149 - Chris Masterjohn, PhD on Analyzing the Hidden Data You're Not Hearing About

23 Helmi 20221h 25min

Part 148 - Dr. Chris Palmer on Incredible Cases of Diet & Lifestyle Reversing Depression, Bipolar, and Schizophrenia

Part 148 - Dr. Chris Palmer on Incredible Cases of Diet & Lifestyle Reversing Depression, Bipolar, and Schizophrenia

In this episode, I had a wonderful conversation with Dr. Chris Palmer who uses diet and lifestyle changes to improve the lives of people suffering from mental and metabolic illness. As you'll learn in the show, there is a metabolic component of many mental health conditions.   Dr. Palmer has been exploring dietary changes, like the ketogenic diet, as treatment for conditions such as schizophrenia, bipolar disorder, and depression. He shares some amazing and inspiring stories that need to be shared with the world if we want to see meaningful changes to our medical system!   Dr. Palmer has been involved in psychiatric research for over 23 years. He received his medical degree from Washington University School of Medicine. He did his internship and psychiatry residency at McLean Hospital, Massachusetts General Hospital, and Harvard Medical School. He is currently the Director of the Department of Postgraduate and Continuing Education at McLean Hospital and an Assistant Professor of Psychiatry at Harvard Medical School.   He has been pioneering the use of the ketogenic diet as a treatment for psychiatric disorders. This is an evidence-based treatment for epilepsy, and epilepsy treatments are commonly used in psychiatry. Additionally, the ketogenic diet has profound effects on brain metabolism that may correct some of the metabolic abnormalities often found in people with mental disorders. He is working with researchers from around the world to assess the effectiveness of this treatment in real people and better understand its mechanisms of action.   Check out his website! - https://www.chrispalmermd.com   DISCLAIMER: The opinions and information provided here by Dr. Chris Palmer and Brian Sanders are not to be taken as medical advice.     SHOW NOTES [3:30] The ketogenic diet and alcoholism [10:30] The ketogenic diet is an evidence-based treatment for epilepsy [13:40] Dr. Chris Palmer's background and personal story [21:40] Why diet works when other treatments fail [26:40] Long-standing psychiatric symptoms resolving with Keto [33:10] Metabolic flexibility and mental health [37:00] Why there's no one-size-fits-all diet [40:40] What happens when patients return to their old habits? [46:00] Treating epilepsy and bipolar disorder with keto [53:40] Mental disorders are metabolic disorders of the brain [57:40] Regular exercise is important, but not enough [1:01:40] Why isn't exercise enough for some people? [1:07:40] Depression is skyrocketing – can diet sometimes help? [1:13:00] Depression and comfort foods [1:15:40] Dr. Chris Palmer is working on a book!   GET THE MEAT! http://NosetoTail.org  GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org  Follow along: http://twitter.com/FoodLiesOrg  http://instagram.com/food.lies  http://facebook.com/FoodLiesOrg

22 Joulu 20211h 20min

Part 147 - An Insider's Look at Public Health Guidelines and the Medical System - Dr. Chris Dan and Dr. Gary Shlifer

Part 147 - An Insider's Look at Public Health Guidelines and the Medical System - Dr. Chris Dan and Dr. Gary Shlifer

In this episode, I sat down with Dr. Chris Dan and Dr. Gary Shlifer to talk about the shortcomings of the medical system and current public health guidelines. Both of them have experienced frustration with the modern medical system, especially as it relates to the pandemic and the prevention of chronic disease.   We discuss the chaotic and confusing public health guidelines over the past 2 years as well as the importance of metabolic health on our immune health. Dr. Chris Dan exposes some of the biggest problems with the healthcare system and explains why he left the hospital.   Dr. Chris Dan is currently a family medicine board certified physician who worked as a full time Hospitalist in Los Angeles County for the past four years. He completed his undergraduate degree at UCI and studied medicine at Western University of Health Sciences in Pomona. During his time as an inpatient physician, he saw the shortcomings of the current medical system in prevention of chronic disease and will be moving on to work outpatient with a focus on returning people to metabolic health.   Dr. Gary Shlifer is a board-certified internal medicine physician specializing in preventative care, nutrition/metabolism and anti-aging medicine. Dr. Gary brings his robust experienced with hospital inpatient medicine to his outpatient primary care practice in order to help prevent and cure disease in his patients. He is the founder of Evolve Healthcare in Los Angeles, a multi-specialty integrative medicine clinic focused on disease prevention and lifestyle optimization.     SHOW NOTES [7:20] Dr. Chris Dan's background [10:50] The problems with inpatient medicine [17:10] Why the medical system is a numbers game [23:10] Chaotic & confusing pandemic guidelines [27:10] Why generic drugs are discouraged [32:40] How COVID affected healthcare workers [39:40] The corporate & bureaucratic structure of healthcare [44:10 Healthcare doesn't make money on healthy people [49:40] The "diabetes diet" in hospitals [54:30] Why Dr. Chris Dan left the hospital [59:50] What's the biggest problem in healthcare? [1:03:10] What you should do if you don't want to burden the healthcare system   GET THE MEAT! http://NosetoTail.org  GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org  Follow along: http://twitter.com/FoodLiesOrg  http://instagram.com/food.lies  http://facebook.com/FoodLiesOrg

15 Joulu 20211h 9min

Part 146 - How a Norwegian Farmer Changed the Mind of the World's Most Powerful Anti-Meat Activist

Part 146 - How a Norwegian Farmer Changed the Mind of the World's Most Powerful Anti-Meat Activist

Today's episode features a farmer from Norway named Raymund. Raymund is truly a hero because he hosted Dr. Gunhild A. Stordalen at his farm where he educated her on the benefits that animal agriculture can have on our ecosystem. Dr. Gunhild A. Stordalen is a very well known environmental activist and the founder of EAT which recommends a mere 14 grams of red meat per day as part of a "Planetary Health Diet."   As you'll learn in this episode, Raymund convinced her that meat and animal agriculture are a sustainable and essential part of our food system. Throughout this episode, we discuss many of the problems with our modern food system. In fact, Raymund runs a decentralized food system in Norway called REKO which connects farmers directly to customers. We are hoping to bring something similar to Texas and eventually all over the United States.   Learn more at https://www.sovereignhumans.org     SHOW NOTES: [6:15] How Raymund knows Gunhild Stordalen of EAT Lancet [10:30] Meat is required for a healthy diet and planet [15:00] What Raymund told Gunhild Stordalen [20:35] Problems with the Planetary Diet [26:40] How consumerism is wasteful [30:20] Why big corporations hate a decentralized food system [37:00] Our changing food & spending habits [40:00] The industrial farming of salmon [43:50] Why raising pigs is so difficult [47:00] How Raymond built a sustainable farm [53:30] Why you should spend more on food and less elsewhere [56:30] Everyone needs their own farmer, not their own doctor [1:01:20] How cities destroyed our food system [1:06:30] Our modern food system is a failed experiment [1:12:45] Vote with your dollar by eating local   GET THE MEAT! http://NosetoTail.org  GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org    Follow along: http://twitter.com/FoodLiesOrg  http://instagram.com/food.lies  http://facebook.com/FoodLiesOrg

8 Joulu 20211h 16min

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