Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1411)

#94 Hacking Your PH, LED lighting, & Smart Drugs with Steven Fowkes Part 1

#94 Hacking Your PH, LED lighting, & Smart Drugs with Steven Fowkes Part 1

We have all heard of “pH,” but do you actually know what it is or how to measure it in your body? In this very special episode of Bulletproof Radio, Steve Fowkes is on the show in part 1 of a two-part series with one of Dave’s mentors and heavy-hitting science experts. Steve’s sophisticated understanding of pH mechanisms of health go far beyond the simplistic "alkalinize, alkalinize, alkalinize" message that most people hear. You’ll discover how to hack your own pH and circadian rhythm and why doing so is essential to increasing your performance. Grab a pen and enjoy. And don’t forget to listen to part 2 later this week!   Steven Wm. Fowkes is an organic chemist by degree and a scientific generalist by nature.  He is author/co-author of six books, five of which are health related, and has published over 100 issues of two health newsletters.  He has been hacking health for four decades in many novel ways, long before self-care and Quantified Self became popular ideas.  One hack was overcoming severe stage fright, which enables Steve to do public speaking engagements (see him at last year's Bulletproof Conference) and TV appearances (including his 15 minutes of fame on Larry King Live). Google him!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Helmi 201449min

#93 Primal Movements with BJ Baker

#93 Primal Movements with BJ Baker

BJ Baker was the first strength and conditioning trainer for the Boston Red Sox and has been involved in the training, preparation, nutritional counseling, and rehabilitation of athletes in virtually every sport. BJ is currently the Head Athletic Trainer at Pure Performance Training and comes on Bulletproof Radio to talk about his experience as a top-level pro in functional movement and physical therapy. You’ll discover why he’s a fan of ‘primal movement,’ the difference between training pro-athletes vs. an average Joe, and what the shortest route to optimal is.   BJ Baker has been involved in the training, preparation, nutritional counseling, and rehabilitation of athletes in virtually every sport. He earned a Bachelor of Science in Physical Education/Athletic Training (Magna Cum Laude) at Cortland State University before going on to complete his Master’s Degree in Exercise Science with a concentration in Sports Medicine from Ithaca College. BJ has served on the Athletic Training staff at Cornell University, Harvard University and was the first Conditioning Coordinator for the Boston Red Sox. He has been married to his wife Laura for 27 years and has two children. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Tammi 201455min

#92 Creating Digital Happiness with Anna Akbari – Podcast

#92 Creating Digital Happiness with Anna Akbari – Podcast

When is the last time you thought about your relationship to technology? It is certainly something to consider these days. On this episode of Bulletproof Radio, digital happiness hacker and identity construction expert, Anna Akbari, enlightens us on the sociology of style and how it can help you perform better. You’ll hear about hacking your own identity, the evolution of cultural perception, and how to create closet catharsis. Oh! And ever wondered what beards say about people? You’ll hear something about that too! This is a great show on a holistic approach to individual empowerment. Enjoy! Anna Akbari, Ph.D., is a sociologist and serial entrepreneur. She taught in the department of Media, Culture, and Communication at New York University and at Parsons The New School for Design. Her research focuses on technology/human relationships, digital happiness, and strategic visual and virtual self-presentation and identity construction (including sartorial semiotics and techniques of the body). Akbari is the founder of Sociology of Style, which blends social science with pop culture analysis and practical advice to offer smart, timely commentary on image-related issues and culture. She is also the founder of Sociology of Style Services, her image consulting company, which addresses identity construction through personal styling, image management, and bodily manipulation. Watch her TED talk on "Digital Happiness.” She currently works and lives between San Francisco and New York City. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Tammi 201456min

#91 Hacking Happiness with Stella Grizont

#91 Hacking Happiness with Stella Grizont

Woopaah! It turns out that happiness really can make or break your performance. On this episode of Bulletproof Radio one of the world’s best and first positive psychologists, Stella Grizont, talks about the science of happiness. And don’t worry! It’s not all puppies and unicorns – although who doesn’t like unicorns? Hear the ‘set point’ theory of happiness, the negativity bias, and even how to hack your way out of a shitty day. Dave even opens up about his most boring job! Oh and didn’t you know? It looks like you can die of a broken heat AND of boredom. Listen up!   Stella Grizont is the founder of WOOPAAH, a company that creates immersive play experiences for people at work to feel happier, more creative, and connected. Some of her clients include Google, Columbia University, and New York City's Department of Transportation. Stella was one of the first 200 people to earn a Masters in Applied Positive Psychology from the University of Pennsylvania. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Tammi 201449min

#90 Engineering Resilience with Andy Hnilo

#90 Engineering Resilience with Andy Hnilo

Looking and feeling your best isn’t just about genetics, you have to work at being optimal. Model, actor, and fellow biohacking geek Andy Hnilo knows exactly what this means. Andy comes on Bulletproof Radio to talk about how he engineered his own resilience after a debilitating car accident using a Bulletproof lifestyle and a whole lot of gratitude. On this episode you will learn Andy’s hacks for having great skin and looking good, why he loves sardines so much, and how he got hit by two cars and was back on the runway in just 3 short months. Three words: deer placenta smoothies! Andy’s a great guy with a ton of passion behind his success.  Enjoy the show!    Andy Hnilo is 32 years old and lives in Los Angeles, CA. As an athlete all of his life, he excelled in baseball and football, earned a baseball scholarship to UC Berkeley and turned down an opportunity to play professional baseball when he landed a role on daytime soap opera, “Days of our Lives.” Andy has since kept very busy with modeling and acting - most recently appearing on HBO’s “Hello Ladies.” Andy has walked the runway for numerous clothing companies such as Calvin Klein, Oakley, Speedo, and has shot over a dozen national commercials for companies like Michelob Ultra, Geico, Nike, Mizuno and most recently Coppertone. After getting hit and run over by two SUV’s, he thought his career was over but through nutrition and relentless hard work, he has found himself in better shape physically and mentally because of it, working more than ever before. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Tammi 201457min

#89 The Virgin Diet with JJ Virgin

#89 The Virgin Diet with JJ Virgin

Best-selling author, nutrition expert, and all-around Bulletproof babe, JJ Virigin comes on the podcast to talk about her top performing diet program and bestselling book, The Virgin Diet and why it makes you better. JJ is highly regarded in the health and wellness industries working with top CEOs and A-list celebrities from around the world, including Gene Simmons, Ben Stiller, Jeanne Tripplehorn, Tracie Thoms, Janeane Garofalo, just for starters. On this episode of Bulletproof Radio you will learn about 7 foods to stop eating now, how JJ used food and supplements to bring her son back from the brink of death, and why JJ is against intermittent fasting for women. Also hear Dave challenge JJ to an arm wrestle and so much more! JJ is all kinds of charming and incredibly knowledgeable. Please enjoy the show!   JJ Virgin is one of the nation’s foremost fitness and nutrition experts, an accomplished public speaker and media personality. Her 25 years in the health and fitness industry and in holistic nutrition and functional medicine has allowed her the opportunity to work with high performance athletes, CEO’s, and A-list celebrities from around the world. JJ is author of NY Times bestseller The Virgin Diet: Drop 7 Foods, Lose 7 Pounds, Just 7 Days and the new Virgin Diet cookbook, she has a show airing on PBS, Drop 7 Foods, Feel Better Fast!, she was a regular on Dr. Phil for 2 years and the co-host of TLC’s Freaky Eaters and has appeared all over the media including the Today Show, Rachel Ray, The Doctors and Access Hollywood. JJ is a member of Mensa, a UCLA graduate and chronic student having taken 40 graduate courses (and counting). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Tammi 201448min

#88 Food Matters with James Colquhoun

#88 Food Matters with James Colquhoun

“You are what you eat.” It’s been talked about for years, and according to filmmaker and nutrition expert James Colquhoun, this sentiment couldn’t be more true.  Colquhoun is on Bulletproof Radio to talk about his documentary film, Food Matters, and the science behind it. On the show James discusses his personal journey with food and what inspires him to help others get serious about their health. On the show you’ll hear an inspiring discussion about how James successfully rid his own father of chronic illness, the problem with “big pharma,” and how real men catch their own babies! This is just the beginning though, there is a ton of useful information to be had on this episode. Enjoy!   James Colquhoun is a nutritional consultant turned filmmaker. Motivated by a chronic illness in his family.  Along with Laurentine ten Bosch, Colquhoun created and filmed Food Matters offering it as a tool for individuals to take charge of their own health. The FoodMatters.tv website is a leading resource in the natural health world with over 3.7 million visitors since 2008. Their latest documentary, HUNGRY FOR CHANGE (2012), reveals how the diet and processed food industries are the enemies of permanent weight loss, vibrant health, and natural living. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Tammi 201452min

#86 Your Personal Paleo Code with Chris Kresser

#86 Your Personal Paleo Code with Chris Kresser

The Paleo Diet has been growing in popularity for a while now. So much so that you might consider it an official fad diet. On this episode of Bulletproof Radio, author and Paleo expert, Chris Kresser, makes a valid and fundamentally sound argument about how that is just not the case! After many years of hacking his own health and discovering the distinct formula that works best for his biology, Kresser is eager to share the formula he thinks will work for everyone – and it’s all about personalization. Chris comes on the show to discuss the principles behind his new book, Your Personal Paleo Code. You’ll hear how a desperate health scare became a big motivator for Kresser, his thoughts on epigenetics, Chris' response to some current Paleo Diet criticisms, and a ton more! Have a great listen and happy New Year!   Chris Kresser, M.S., L.Ac, is a practitioner of integrative and functional medicine and the creator of ChrisKresser.com, one of the most respected natural health sites in the world. He developed Your Personal Paleo Code based on more than ten years of research, his own recovery from a debilitating, decade-long illness, and his clinical work with patients. Chris was recently named one of the 50 most influential people in health and fitness by Greatist.com, along with Michelle Obama, Dr. Oz, Dr. Weil, and Deepak Chopra. Paleo Magazine declared Chris’s blog the top science-oriented blog in the Paleo community, and he is a regular health columnist at the Huffington Post. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Joulu 201349min

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